actb1 actin, beta 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: actb1provided by ZNC
Official Full Name: actin, beta 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-000329-1
See related: Ensembl:ENSDARG00000037746 AllianceGenome:ZFIN:ZDB-GENE-000329-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ACTB; bact; actba; bactzf; B-ACTZF; bactin1; wu:fd18f05
Summary: Predicted to be a structural constituent of postsynaptic actin cytoskeleton. Predicted to be located in several cellular components, including actin cytoskeleton; dense body; and focal adhesion. Predicted to be active in actin filament. Is expressed in several structures, including eye; hematopoietic cell; liver; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to several human genes including ACTB (actin beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (8649102..8652677, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (7964993..7968521, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic loss of roundabout homolog 2 protein (robo2)displayed decreased synaptic oxytocin (OXT) content and robo2 mutants displayed reduced mobility of the actin probe Lifeact-EGFP in OXT synapses.
Title: Robo2 regulates synaptic oxytocin content by affecting actin dynamics.
HnRNP-R-mediated axonal beta-actin mRNA translocation plays an essential physiological role for axon growth and presynaptic differentiation.
Title: The heterogeneous nuclear ribonucleoprotein-R is necessary for axonal beta-actin mRNA translocation in spinal motor neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC156124P2 (e-PCR)
- UniSTS:271360

PMC201106P1 (e-PCR)
- UniSTS:271883

Acat1 (e-PCR), detects polymorphism
- UniSTS:546573

PMC138261P1 (e-PCR)
- UniSTS:270864

PMC180915P1 (e-PCR)
- UniSTS:271667

bact1 (e-PCR)
- UniSTS:186931

bact2 (e-PCR)
- UniSTS:186932

PMC85361P1 (e-PCR)
- UniSTS:273471

PMC133768P1 (e-PCR)
- UniSTS:270660

PMC110143P1 (e-PCR)
- UniSTS:270184

bactin1 (e-PCR), detects polymorphism
- UniSTS:205676

PMC356969P12 (e-PCR)
- UniSTS:273274

PMC24561P1 (e-PCR)
- UniSTS:272264

fc18f06 (e-PCR)
- UniSTS:204702

AW184596 (e-PCR)
- UniSTS:205751

fd18f05.x1 (e-PCR)
- UniSTS:204227

fb52b09.x1 (e-PCR)
- UniSTS:190663

PMC97559P2 (e-PCR)
- UniSTS:273652

PMC97568P1 (e-PCR)
- UniSTS:273653

PMC22644P1 (e-PCR)
- UniSTS:272120

PMC129447P1 (e-PCR)
- UniSTS:270591

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of postsynaptic actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in dense body	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin, cytoplasmic 1

Names: beta-actin; beta-actin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131031.2 → NP_571106.2 actin, cytoplasmic 1

Status: VALIDATED

Source sequence(s)

AL928650

UniProtKB/Swiss-Prot

Q6P3K9, Q7ZVI7

Related

ENSDARP00000054986.5, ENSDART00000054987.7

Conserved Domains (1) summary

PTZ00281
Location:1 → 375

PTZ00281; actin; Provisional