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pycard PYD and CARD domain containing [ Danio rerio (zebrafish) ]

Gene ID: 57923, updated on 2-Nov-2024

Summary

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Official Symbol
pycardprovided by ZNC
Official Full Name
PYD and CARD domain containingprovided by ZNC
Primary source
ZFIN:ZDB-GENE-000511-2
See related
Ensembl:ENSDARG00000040076 AllianceGenome:ZFIN:ZDB-GENE-000511-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ASC; asc1; zAsc; zgc:109874
Summary
Enables Pyrin domain binding activity. Acts upstream of or within defense response to other organism; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; and regulation of inflammatory response. Part of NLRP1 inflammasome complex and NLRP3 inflammasome complex. Is expressed in several structures, including digestive system; integument; periderm; pleuroperitoneal region; and unfertilized egg. Orthologous to human PYCARD (PYD and CARD domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See pycard in Genome Data Viewer
Location:
chromosome: 16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (41984032..41990421, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (42034000..42040382, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene sodium channel, voltage-gated, type I, beta a Neighboring gene GRAM domain containing 1A Neighboring gene si:ch211-225p5.8 Neighboring gene caspase a Neighboring gene ETS1-related protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression analysis of the ASC gene from mandarin fish and its regulation of NF-kappaB activation. Sun Y, et al. Dev Comp Immunol, 2008. PMID 17850868
  2. Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation. Progatzky F, et al. Nat Commun, 2014 Dec 23. PMID 25536194, Free PMC Article
  3. Functional characterization of apoptosis-associated speck-like protein (ASC) of the goldfish (Carassius auratus L.). Xie J, et al. Dev Comp Immunol, 2016 Dec. PMID 27451255
  4. Olfactory sensory neurons mediate ultrarapid antiviral immune responses in a TrkA-dependent manner. Sepahi A, et al. Proc Natl Acad Sci U S A, 2019 Jun 18. PMID 31160464, Free PMC Article
  5. Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection. Matty MA, et al. Elife, 2019 Jan 29. PMID 30693866, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109874

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Pyrin domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cysteine-type endopeptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NLRP1 inflammasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NLRP1 inflammasome complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of NLRP3 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NLRP3 inflammasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NLRP6 inflammasome complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of canonical inflammasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of canonical inflammasome complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
apoptosis-associated speck-like protein containing a CARD
Names
PYD and CARD domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131495.3 → NP_571570.3  apoptosis-associated speck-like protein containing a CARD

    Status: VALIDATED

    Source sequence(s)
    BX649388
    Related
    ENSDARP00000055920.5, ENSDART00000055921.7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    41984032..41990421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I9N6.1 GenPept UniProtKB/Swiss-Prot:Q9I9N6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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