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PTPRF protein tyrosine phosphatase receptor type F [ Homo sapiens (human) ]

Gene ID: 5792, updated on 11-Apr-2024

Summary

Official Symbol
PTPRFprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Fprovided by HGNC
Primary source
HGNC:HGNC:9670
See related
Ensembl:ENSG00000142949 MIM:179590; AllianceGenome:HGNC:9670
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LAR; BNAH2
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 56.2), skin (RPKM 52.7) and 21 other tissues See more
Orthologs
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Genomic context

See PTPRF in Genome Data Viewer
Location:
1p34.2
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (43522051..43623666)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (43392482..43494171)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (43991708..44089337)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SZT2 subunit of KICSTOR complex Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43916604-43917491 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43917492-43918378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 784 Neighboring gene SZT2 antisense RNA 1 Neighboring gene microRNA 6735 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:43937485-43938684 Neighboring gene HYI antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4928 Neighboring gene hydroxypyruvate isomerase (putative) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43986941-43987441 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:43997400-43997972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43998601-43999102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:43999103-43999602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44000549-44001411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44014162-44014968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44014969-44015773 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44022869-44023446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44023447-44024024 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44026337-44026914 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44030770-44031565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44038483-44038984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44040406-44041268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44041269-44042129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44046933-44047754 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44061284-44061784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44061785-44062285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:44063935-44064436 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:44086190-44086364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 788 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:44125453-44126129 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:44126130-44126805 Neighboring gene uncharacterized LOC124904165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 921 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:44131983-44133182 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:44142744-44142920 Neighboring gene lysine demethylase 4A Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:44172642-44173159 Neighboring gene KDM4A antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Breasts and/or nipples, aplasia or hypoplasia of, 2
MedGen: C4014918 OMIM: 616001 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.
EBI GWAS Catalog
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRF PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ43335, FLJ45062, FLJ45567

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chondroitin sulfate proteoglycan binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase F
Names
LCA-homolog
leukocyte antigen-related (LAR) PTP receptor
leukocyte antigen-related tyrosine phosphatase
leukocyte common antigen related
protein tyrosine phosphatase, receptor type, F polypeptide
receptor-linked protein-tyrosine phosphatase LAR
NP_001316066.1
NP_001316067.1
NP_001316068.1
NP_001316069.1
NP_002831.2
NP_569707.2
XP_005271136.1
XP_005271137.1
XP_005271138.1
XP_005271139.1
XP_006710858.1
XP_006710859.1
XP_006710860.1
XP_006710861.1
XP_006710862.1
XP_006710863.1
XP_006710864.1
XP_011540173.1
XP_011540174.1
XP_011540175.1
XP_016857431.1
XP_016857433.1
XP_016857434.1
XP_016857435.1
XP_047282431.1
XP_047282439.1
XP_047282442.1
XP_047282448.1
XP_047282449.1
XP_047282457.1
XP_047282460.1
XP_047282463.1
XP_047282468.1
XP_047282470.1
XP_047282475.1
XP_054193929.1
XP_054193930.1
XP_054193931.1
XP_054193932.1
XP_054193933.1
XP_054193934.1
XP_054193935.1
XP_054193936.1
XP_054193937.1
XP_054193938.1
XP_054193939.1
XP_054193940.1
XP_054193941.1
XP_054193942.1
XP_054193943.1
XP_054193944.1
XP_054193945.1
XP_054193946.1
XP_054193947.1
XP_054193948.1
XP_054193949.1
XP_054193950.1
XP_054193951.1
XP_054193952.1
XP_054193953.1
XP_054193954.1
XP_054193955.1
XP_054193956.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047072.1 RefSeqGene

    Range
    13646..106429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329137.2NP_001316066.1  receptor-type tyrosine-protein phosphatase F isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC092815, AL583862, BU624266, DA339772
    UniProtKB/TrEMBL
    Q5W9G3
  2. NM_001329138.2NP_001316067.1  receptor-type tyrosine-protein phosphatase F isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC092815, AL583862, BU624266, DA339772
    UniProtKB/TrEMBL
    Q5W9G3
  3. NM_001329139.2NP_001316068.1  receptor-type tyrosine-protein phosphatase F isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC092815, AL583862, BU624266
    UniProtKB/TrEMBL
    Q5W9G3
  4. NM_001329140.2NP_001316069.1  receptor-type tyrosine-protein phosphatase F isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AB621807, AC092815, AL583862, BU624266
    UniProtKB/TrEMBL
    Q5W9G3
  5. NM_002840.5NP_002831.2  receptor-type tyrosine-protein phosphatase F isoform 1 precursor

    See identical proteins and their annotated locations for NP_002831.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC092815, BC048768, BU624266, Y00815
    Consensus CDS
    CCDS489.2
    UniProtKB/Swiss-Prot
    D3DPX6, D3DPX7, P10586, Q5T021, Q5T022, Q5W9G2, Q86WS0
    UniProtKB/TrEMBL
    H0Y6Z7
    Related
    ENSP00000353030.4, ENST00000359947.9
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13511606
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13771606
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:609696
    fn3; Fibronectin type III domain
  6. NM_130440.4NP_569707.2  receptor-type tyrosine-protein phosphatase F isoform 2 precursor

    See identical proteins and their annotated locations for NP_569707.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC092815, BC048768, BU624266, Y00815
    Consensus CDS
    CCDS490.2
    UniProtKB/TrEMBL
    H0Y6Z7
    Related
    ENSP00000398822.1, ENST00000438120.5
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13421597
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13681597
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:609696
    fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    43522051..43623666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541873.3XP_011540175.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_011540175.1

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (8) summary
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14626
    Location:13501625
    R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
    cd14629
    Location:16271917
    R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:136226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  2. XM_011541871.4XP_011540173.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_011540173.1

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (8) summary
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14626
    Location:13501625
    R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
    cd14629
    Location:16271917
    R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:136226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  3. XM_011541872.4XP_011540174.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_011540174.1

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (8) summary
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14626
    Location:13501625
    R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
    cd14629
    Location:16271917
    R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:136226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  4. XM_006710795.4XP_006710858.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_006710858.1

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (8) summary
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14626
    Location:13501625
    R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
    cd14629
    Location:16271917
    R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:136226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  5. XM_005271079.4XP_005271136.1  receptor-type tyrosine-protein phosphatase F isoform X1

    See identical proteins and their annotated locations for XP_005271136.1

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (8) summary
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14626
    Location:13501625
    R-PTPc-F-1; catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1
    cd14629
    Location:16271917
    R-PTP-F-2; PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3336
    Ig; Ig strand A [structural motif]
    cd05738
    Location:136226
    IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
    cd05739
    Location:239320
    IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains
  6. XM_006710797.4XP_006710860.1  receptor-type tyrosine-protein phosphatase F isoform X5

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13551610
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13811610
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  7. XM_006710801.4XP_006710864.1  receptor-type tyrosine-protein phosphatase F isoform X18

    UniProtKB/TrEMBL
    Q5W9G3
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:11731428
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:11991428
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  8. XM_047426504.1XP_047282460.1  receptor-type tyrosine-protein phosphatase F isoform X20

  9. XM_006710796.4XP_006710859.1  receptor-type tyrosine-protein phosphatase F isoform X3

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13571612
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13831612
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  10. XM_006710798.4XP_006710861.1  receptor-type tyrosine-protein phosphatase F isoform X8

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13461601
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:13721601
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:613700
    fn3; Fibronectin type III domain
  11. XM_047426501.1XP_047282457.1  receptor-type tyrosine-protein phosphatase F isoform X19

  12. XM_047426512.1XP_047282468.1  receptor-type tyrosine-protein phosphatase F isoform X22

  13. XM_006710799.4XP_006710862.1  receptor-type tyrosine-protein phosphatase F isoform X11

    Conserved Domains (8) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:12641519
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:12901519
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
  14. XM_047426492.1XP_047282448.1  receptor-type tyrosine-protein phosphatase F isoform X13

  15. XM_017001946.2XP_016857435.1  receptor-type tyrosine-protein phosphatase F isoform X25

    UniProtKB/TrEMBL
    Q5W9G3
  16. XM_006710800.4XP_006710863.1  receptor-type tyrosine-protein phosphatase F isoform X12

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (8) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:250318
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:12551510
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:242319
    IG_like; Immunoglobulin like
    cd00047
    Location:12811510
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:323412
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
  17. XM_017001944.2XP_016857433.1  receptor-type tyrosine-protein phosphatase F isoform X16

    UniProtKB/TrEMBL
    H0Y6Z7
  18. XM_005271080.4XP_005271137.1  receptor-type tyrosine-protein phosphatase F isoform X2

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13621617
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13881617
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:609696
    fn3; Fibronectin type III domain
  19. XM_047426507.1XP_047282463.1  receptor-type tyrosine-protein phosphatase F isoform X21

  20. XM_005271081.4XP_005271138.1  receptor-type tyrosine-protein phosphatase F isoform X6

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (9) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:13531608
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:13791608
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:609696
    fn3; Fibronectin type III domain
  21. XM_047426514.1XP_047282470.1  receptor-type tyrosine-protein phosphatase F isoform X23

  22. XM_017001945.2XP_016857434.1  receptor-type tyrosine-protein phosphatase F isoform X14

    UniProtKB/TrEMBL
    H0Y6Z7
  23. XM_005271082.4XP_005271139.1  receptor-type tyrosine-protein phosphatase F isoform X17

    UniProtKB/TrEMBL
    H0Y6Z7
    Conserved Domains (8) summary
    cd00096
    Location:50121
    Ig; Immunoglobulin domain
    cd05738
    Location:152226
    Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    cd05739
    Location:246314
    Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
    smart00194
    Location:12401495
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:238315
    IG_like; Immunoglobulin like
    cd00047
    Location:12661495
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:319408
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:33124
    I-set; Immunoglobulin I-set domain
  24. XM_047426493.1XP_047282449.1  receptor-type tyrosine-protein phosphatase F isoform X15

  25. XM_047426486.1XP_047282442.1  receptor-type tyrosine-protein phosphatase F isoform X10

    Related
    ENSP00000408952.1, ENST00000429895.5
  26. XM_047426475.1XP_047282431.1  receptor-type tyrosine-protein phosphatase F isoform X7

  27. XM_047426483.1XP_047282439.1  receptor-type tyrosine-protein phosphatase F isoform X9

  28. XM_047426519.1XP_047282475.1  receptor-type tyrosine-protein phosphatase F isoform X24

  29. XM_017001942.3XP_016857431.1  receptor-type tyrosine-protein phosphatase F isoform X4

    UniProtKB/TrEMBL
    H0Y6Z7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    43392482..43494171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337957.1XP_054193932.1  receptor-type tyrosine-protein phosphatase F isoform X1

  2. XM_054337955.1XP_054193930.1  receptor-type tyrosine-protein phosphatase F isoform X1

  3. XM_054337956.1XP_054193931.1  receptor-type tyrosine-protein phosphatase F isoform X1

  4. XM_054337954.1XP_054193929.1  receptor-type tyrosine-protein phosphatase F isoform X1

  5. XM_054337961.1XP_054193936.1  receptor-type tyrosine-protein phosphatase F isoform X5

  6. XM_054337974.1XP_054193949.1  receptor-type tyrosine-protein phosphatase F isoform X18

  7. XM_054337976.1XP_054193951.1  receptor-type tyrosine-protein phosphatase F isoform X20

  8. XM_054337959.1XP_054193934.1  receptor-type tyrosine-protein phosphatase F isoform X3

  9. XM_054337964.1XP_054193939.1  receptor-type tyrosine-protein phosphatase F isoform X8

  10. XM_054337975.1XP_054193950.1  receptor-type tyrosine-protein phosphatase F isoform X19

  11. XM_054337978.1XP_054193953.1  receptor-type tyrosine-protein phosphatase F isoform X22

  12. XM_054337967.1XP_054193942.1  receptor-type tyrosine-protein phosphatase F isoform X11

  13. XM_054337969.1XP_054193944.1  receptor-type tyrosine-protein phosphatase F isoform X13

  14. XM_054337981.1XP_054193956.1  receptor-type tyrosine-protein phosphatase F isoform X25

  15. XM_054337968.1XP_054193943.1  receptor-type tyrosine-protein phosphatase F isoform X12

  16. XM_054337972.1XP_054193947.1  receptor-type tyrosine-protein phosphatase F isoform X16

  17. XM_054337958.1XP_054193933.1  receptor-type tyrosine-protein phosphatase F isoform X2

  18. XM_054337977.1XP_054193952.1  receptor-type tyrosine-protein phosphatase F isoform X21

  19. XM_054337962.1XP_054193937.1  receptor-type tyrosine-protein phosphatase F isoform X6

  20. XM_054337979.1XP_054193954.1  receptor-type tyrosine-protein phosphatase F isoform X23

  21. XM_054337970.1XP_054193945.1  receptor-type tyrosine-protein phosphatase F isoform X14

  22. XM_054337973.1XP_054193948.1  receptor-type tyrosine-protein phosphatase F isoform X17

  23. XM_054337971.1XP_054193946.1  receptor-type tyrosine-protein phosphatase F isoform X15

  24. XM_054337966.1XP_054193941.1  receptor-type tyrosine-protein phosphatase F isoform X10

  25. XM_054337963.1XP_054193938.1  receptor-type tyrosine-protein phosphatase F isoform X7

  26. XM_054337965.1XP_054193940.1  receptor-type tyrosine-protein phosphatase F isoform X9

  27. XM_054337980.1XP_054193955.1  receptor-type tyrosine-protein phosphatase F isoform X24

  28. XM_054337960.1XP_054193935.1  receptor-type tyrosine-protein phosphatase F isoform X4