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MARK4 microtubule affinity regulating kinase 4 [ Homo sapiens (human) ]

Gene ID: 57787, updated on 5-Mar-2024

Summary

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Official Symbol
MARK4provided by HGNC
Official Full Name
microtubule affinity regulating kinase 4provided by HGNC
Primary source
HGNC:HGNC:13538
See related
Ensembl:ENSG00000007047 MIM:606495; AllianceGenome:HGNC:13538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARK4L; MARK4S; MARKL1; PAR-1D; MARKL1L
Summary
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Broad expression in testis (RPKM 14.0), brain (RPKM 8.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45251271..45305284)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48077944..48131959)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45754529..45808542)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14789 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:45682829-45683329 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45683755-45684256 Neighboring gene Sharpr-MPRA regulatory region 2997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10758 Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 3 Neighboring gene Sharpr-MPRA regulatory region 12921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45719170-45719704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45720327-45721022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45721023-45721716 Neighboring gene exocyst complex component 3 like 2 Neighboring gene exocyst complex component 3 like 4 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45748359-45749355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10759 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:45755437-45755993 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45767676-45768261 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:45768262-45768846 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:45794892-45795094 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:45811788-45811945 Neighboring gene heart enhancer 22 Neighboring gene creatine kinase, M-type Neighboring gene ribosomal protein S16 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4. Anwar S, et al. J Cell Biochem, 2022 Feb. PMID 34751461
  2. Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases. Anwar S, et al. Int J Biol Macromol, 2020 Oct 15. PMID 32535203
  3. Impact of glioblastoma multiforme associated mutations on the structure and function of MAP/microtubule affinity regulating kinase 4. Naqvi AAT, et al. J Biomol Struct Dyn, 2021 Mar. PMID 32141394
  4. Structure and dynamics of inactive and active MARK4: conformational switching through the activation process. Ahrari S, et al. J Biomol Struct Dyn, 2020 May. PMID 31411112
  5. Differential Expression of MARK4 Protein and Related Perturbations in Females with Ovulatory PCOS. Fazilat A, et al. Endocr Metab Immune Disord Drug Targets, 2019. PMID 31322078

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
    Title: Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification.
  2. Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism.
    Title: Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism.
  3. MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKalpha1/mTOR/HIF-1alpha signaling pathway.
    Title: MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway.
  4. Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4.
    Title: Myricetin inhibits breast and lung cancer cells proliferation via inhibiting MARK4.
  5. Structure and dynamics of inactive and active MARK4: conformational switching through the activation process.
    Title: Structure and dynamics of inactive and active MARK4: conformational switching through the activation process.
  6. Impact of glioblastoma multiforme associated mutations on the structure and function of MAP/microtubule affinity regulating kinase 4.
    Title: Impact of glioblastoma multiforme associated mutations on the structure and function of MAP/microtubule affinity regulating kinase 4.
  7. Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases.
    Title: Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases.
  8. Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
    Title: Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration.
  9. Reduced expression of MARK4 protein in ovulatory polycystic ovarian syndrome increases the risk of hyperlipidemia, hyperandrogenism and metabolic syndrome.
    Title: Differential Expression of MARK4 Protein and Related Perturbations in Females with Ovulatory PCOS.
  10. MARK4-dependent NLRP3 inflammasome activation in the hematopoietic cells regulates the development of atherosclerosis.
    Title: MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12177, FLJ90097, KIAA1860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
  
enables cytoskeletal anchor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gamma-tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
  
enables protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tau-protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tau-protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tau-protein kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables ubiquitin binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule bundle formation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of programmed cell death NAS
Non-traceable Author Statement
more info
  
involved_in positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
part_of gamma-tubulin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAP/microtubule affinity-regulating kinase 4
Names
MAP/microtubule affinity-regulating kinase like 1
MARK4 serine/threonine protein kinase
epididymis secretory sperm binding protein
NP_001186796.1
NP_113605.2
XP_006723370.1
XP_054177554.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199867.2 → NP_001186796.1  MAP/microtubule affinity-regulating kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_001186796.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC005581, AC005781, AC006126
    Consensus CDS
    CCDS56097.1
    UniProtKB/Swiss-Prot
    Q8NG37, Q96JG7, Q96L34, Q96SQ2, Q9BYD8
    Related
    ENSP00000262891.3, ENST00000262891.9
    Conserved Domains (4) summary
    cd12197
    Location:654 → 752
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:59 → 310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:328 → 370
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:58 → 310
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

  2. NM_031417.4 → NP_113605.2  MAP/microtubule affinity-regulating kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_113605.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC005581, AC005781, AC006126
    Consensus CDS
    CCDS12658.1
    UniProtKB/Swiss-Prot
    Q96L34
    Related
    ENSP00000300843.3, ENST00000300843.8
    Conserved Domains (3) summary
    smart00220
    Location:59 → 310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:328 → 370
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:58 → 310
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    45251271..45305284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723307.5 → XP_006723370.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

    Conserved Domains (4) summary
    cd12197
    Location:587 → 685
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:12 → 243
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:261 → 303
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:18 → 243
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48077944..48131959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321579.1 → XP_054177554.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96L34.1 GenPept UniProtKB/Swiss-Prot:Q96L34

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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