Rhox4b reproductive homeobox 4B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhox4bprovided by MGI
Official Full Name: reproductive homeobox 4Bprovided by MGI
Primary source: MGI:MGI:1930129
See related: Ensembl:ENSMUSG00000071771 AllianceGenome:MGI:1930129
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ehox; Rhox4a; Rhox4.2; 5430432L21Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including branchial pouch; early conceptus; foregut diverticulum; genitourinary system; and thymus. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: This gene was previously named "Rhox4a" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox4.2" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox4b. [07 Jan 2013]
Expression: Biased expression in placenta adult (RPKM 4.6) and thymus adult (RPKM 0.4) See more
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Genomic context

Location:: X A3.3; X 21.73 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (36614147..36618931)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (37432494..37437278)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mrj(-/-) chorions at embryonic day 8.5 have expanded Rhox4b expression domains and do not form normal layers of gene expression suggesting that chorion patterning requires Mrj.
Title: Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development.
These results suggest that NFY is an essential regulatory factor for Ehox transcriptional activity, which is important for the post-implantation stage of the developing embryo.
Title: Cloning and characterization of the 5'-flanking region of the Ehox gene.
Results suggest that Ehox is a novel homeobox-containing gene that is essential for the earliest stages of murine ES cell differentiation.
Title: Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation.
Ehox is expressed in trophoblast stem cells and pharyngeal pouch endoderm
Title: Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm.

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:493108

NoName (e-PCR)
- UniSTS:548409

BB193628 (e-PCR)
- UniSTS:209513

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: reproductive homeobox 4B

Names: ES cell derived homeobox containing; homeobox protein EHOX; reproductive homeobox on X chromosome 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021300.2 → NP_067275.1 reproductive homeobox 4B

See identical proteins and their annotated locations for NP_067275.1

Status: VALIDATED

Source sequence(s)

AJ972666

Consensus CDS

CCDS30077.1

UniProtKB/TrEMBL

B7ZWM1, Q9JI43

Related

ENSMUSP00000094197.5, ENSMUST00000096458.5

Conserved Domains (2) summary

cd00086
Location:129 → 187

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

cl21455
Location:41 → 126

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases