NCOA5 nuclear receptor coactivator 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NCOA5provided by HGNC
Official Full Name: nuclear receptor coactivator 5provided by HGNC
Primary source: HGNC:HGNC:15909
See related: Ensembl:ENSG00000124160 MIM:616825; AllianceGenome:HGNC:15909
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CIA; bA465L10.6
Summary: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Expression: Ubiquitous expression in testis (RPKM 19.7), ovary (RPKM 15.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q13.12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (46060991..46089962, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (47797006..47826000, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (44689630..44718601, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?
Title: Could NCOA5 a novel candidate gene for multiple sclerosis susceptibility?
NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
Title: NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
Analysis of Nuclear Receptor Coactivator 5 (NCOA5) Messenger RNA Expression and rs2903908 Single Nucleotide Polymorphism of NCOA5 in an Egyptian Cohort with Behcet's Disease: A Single-Center Case-control Study.
Title: Analysis of Nuclear Receptor Coactivator 5 (NCOA5) Messenger RNA Expression and rs2903908 Single Nucleotide Polymorphism of NCOA5 in an Egyptian Cohort with Behçet's Disease: A Single-Center Case-control Study.
Nuclear Receptor Coactivator 5 is Correlated with Progression in Breast Carcinoma.
Title: Nuclear Receptor Coactivator 5 is Correlated with Progression in Breast Carcinoma.
Results found the expression levels of NCOA5 mRNA and protein significantly decreased in cervical cancer (CC) tissues and correlated with poor overall survival. Its upregulation might suppress cancer cell proliferation, migration, and invasion by inactivating NOTCH3 signaling pathway. These findings suggest that NCOA5 acts as a tumor suppressor and represents a potential novel prognostic marker for overall survival in CC.
Title: Low expression of NCOA5 predicts poor prognosis in human cervical cancer and promotes proliferation, migration, and invasion of cervical cancer cell lines by regulating notch3 signaling pathway.
knockout of NCOA5 can suppress the epithelial - mesenchymal transition (EMT) in hepatocellular carcinoma cells.
Title: Knockout of NCOA5 impairs proliferation and migration of hepatocellular carcinoma cells by suppressing epithelial-to-mesenchymal transition.
This study provides new insights and evidences that NOCA5 over-expression was significantly correlated with progression and prognosis in luminal breast cancer. However, the precise cellular mechanisms for NOCA5 in luminal breast cancer need to be further explored.
Title: NCOA5 is correlated with progression and prognosis in luminal breast cancer.
NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma.
Title: NCOA5 low expression correlates with survival in esophageal squamous cell carcinoma.
suggest that NCOA5 is a haploinsufficient tumor suppressor and that NCOA5 deficiency increases susceptibility to both glucose intolerance and HCC, partially by increasing IL-6 expression
Title: NCOA5 haploinsufficiency results in glucose intolerance and subsequent hepatocellular carcinoma.
gene polymorphism confers susceptibility to psoriasis in a Southern European population
Title: A CD40 and an NCOA5 gene polymorphism confer susceptibility to psoriasis in a Southern European population: a case-control study.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL034496 (e-PCR)
- UniSTS:94235

D20S585E (e-PCR)
- UniSTS:5947

RH91408 (e-PCR)
- UniSTS:85335

STS-D25957 (e-PCR)
- UniSTS:45461

RH68083 (e-PCR)
- UniSTS:25503

G19972 (e-PCR)
- UniSTS:972

A001X16 (e-PCR)
- UniSTS:973

SGC34149 (e-PCR)
- UniSTS:41954

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
located_in extracellular space	HDA more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: nuclear receptor coactivator 5

Names: NCoA-5; coactivator independent of AF-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348148.2 → NP_001335077.1 nuclear receptor coactivator 5 isoform 2

Status: REVIEWED

Source sequence(s)

AL035662, AL162458

Conserved Domains (1) summary

COG0124
Location:81 → 151

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
NM_001348149.2 → NP_001335078.1 nuclear receptor coactivator 5 isoform 3

Status: REVIEWED

Source sequence(s)

AL035662, AL162458

Conserved Domains (2) summary

COG0124
Location:186 → 256

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

PRK12678
Location:32 → 118

PRK12678; transcription termination factor Rho; Provisional
NM_001348150.2 → NP_001335079.1 nuclear receptor coactivator 5 isoform 4

Status: REVIEWED

Source sequence(s)

AL035662, AL162458, BC056872, CN369226

Conserved Domains (1) summary

COG0124
Location:123 → 193

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
NM_001348151.2 → NP_001335080.1 nuclear receptor coactivator 5 isoform 5

Status: REVIEWED

Source sequence(s)

AL035662, AL162458

Conserved Domains (1) summary

COG0124
Location:81 → 151

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
NM_020967.3 → NP_066018.1 nuclear receptor coactivator 5 isoform 1

See identical proteins and their annotated locations for NP_066018.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AF230533, AL035662, AL162458, CN369226

Consensus CDS

CCDS13392.1

UniProtKB/Swiss-Prot

B2RTV9, E1P5R0, Q6HA99, Q9H1F2, Q9H2T2, Q9H4Y9, Q9HCD5

Related

ENSP00000290231.6, ENST00000290231.11

Conserved Domains (2) summary

COG0124
Location:186 → 256

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

PRK12678
Location:32 → 135

PRK12678; transcription termination factor Rho; Provisional