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SEMA4G semaphorin 4G [ Homo sapiens (human) ]

Gene ID: 57715, updated on 11-Apr-2024

Summary

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Official Symbol
SEMA4Gprovided by HGNC
Official Full Name
semaphorin 4Gprovided by HGNC
Primary source
HGNC:HGNC:10735
See related
Ensembl:ENSG00000095539 MIM:618991; AllianceGenome:HGNC:10735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Expression
Broad expression in duodenum (RPKM 18.5), small intestine (RPKM 15.9) and 20 other tissues See more
Orthologs
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Genomic context

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See SEMA4G in Genome Data Viewer
Location:
10q24.31
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (100969504..100985616)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (101852879..101868991)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102729261..102745373)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102496683-102497428 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102497429-102498172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102505530-102506071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102509961-102510895 Neighboring gene paired box 2 Neighboring gene VISTA enhancer hs229 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102550131-102551044 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:102551431-102551607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102562802-102563302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102567263-102567763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102576822-102577322 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:102606788-102607987 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102633779-102634445 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:102649745-102650944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3901 Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene Sharpr-MPRA regulatory region 3697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102755784-102756653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2713 Neighboring gene microRNA 608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2714 Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper tumor suppressor 2 Neighboring gene PDZ domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular mechanisms of axon guidance. Dickson BJ. Science, 2002 Dec 6. PMID 12471249
  2. Semaphorins: contributors to structural stability of hippocampal networks? Holtmaat AJ, et al. Prog Brain Res, 2002. PMID 12432760
  3. The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type. Wu S, et al. Tumour Biol, 2017 Jun. PMID 28653886
  4. Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk. Shen Z, et al. BMC Med Genomics, 2023 Feb 4. PMID 36737753, Free PMC Article
  5. Semaphorin junction: making tracks toward neural connectivity. Pasterkamp RJ, et al. Curr Opin Neurobiol, 2003 Feb. PMID 12593985

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.
    Title: Variants in TPO rs2048722, PTCSC2 rs925489 and SEMA4G rs4919510 affect thyroid carcinoma susceptibility risk.
  2. These findings provide evidence that the miR-608 rs4919510 polymorphism may modify cancer susceptibility in a type-specific manner. Furthermore, SEMA4G may function as an oncogene or tumour suppressor to regulate tumour development in a type-specific manner. Further studies with experimental evaluations are warranted.
    Title: The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20590, KIAA1619, MGC102867

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
semaphorin-4G
Names
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001203244.1 → NP_001190173.1  semaphorin-4G isoform 2 precursor

    See identical proteins and their annotated locations for NP_001190173.1

    Status: REVIEWED

    Source sequence(s)
    BC020960, BC051030, BC128579
    Consensus CDS
    CCDS55724.1
    UniProtKB/Swiss-Prot
    Q9NTN9
    UniProtKB/TrEMBL
    Q9NWU8
    Related
    ENSP00000430175.1, ENST00000517724.5
    Conserved Domains (2) summary
    pfam01437
    Location:507 → 557
    PSI; Plexin repeat
    cl15693
    Location:47 → 506
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  2. NM_001393925.1 → NP_001380854.1  semaphorin-4G isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL133215
    Consensus CDS
    CCDS91320.1
    UniProtKB/Swiss-Prot
    A1A5C6, A6NJY8, Q58EY1, Q9HCF3, Q9NTN9
    Related
    ENSP00000430881.1, ENST00000521006.5
    Conserved Domains (3) summary
    cd11262
    Location:47 → 506
    Sema_4G; The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G)
    pfam01437
    Location:507 → 557
    PSI; Plexin repeat
    cd05872
    Location:567 → 650
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B

  3. NM_017893.4 → NP_060363.2  semaphorin-4G isoform 1 precursor

    See identical proteins and their annotated locations for NP_060363.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL133215
    Consensus CDS
    CCDS7501.1
    UniProtKB/Swiss-Prot
    Q9NTN9
    Related
    ENSP00000210633.3, ENST00000210633.4
    Conserved Domains (3) summary
    cd05872
    Location:572 → 655
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cd11262
    Location:47 → 506
    Sema_4G; The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G)
    pfam01437
    Location:507 → 557
    PSI; Plexin repeat

RNA

  1. NR_172052.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133215

  2. NR_172053.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133215

  3. NR_172054.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133215

  4. NR_172056.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133215

  5. NR_172057.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL133215
    Related
    ENST00000476171.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    100969504..100985616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007061978.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    101852879..101868991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008488244.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NTN9.1 GenPept UniProtKB/Swiss-Prot:Q9NTN9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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