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USP28 ubiquitin specific peptidase 28 [ Homo sapiens (human) ]

Gene ID: 57646, updated on 3-Nov-2024

Summary

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Official Symbol
USP28provided by HGNC
Official Full Name
ubiquitin specific peptidase 28provided by HGNC
Primary source
HGNC:HGNC:12625
See related
Ensembl:ENSG00000048028 MIM:610748; AllianceGenome:HGNC:12625
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016]
Expression
Ubiquitous expression in heart (RPKM 11.8), lymph node (RPKM 4.2) and 24 other tissues See more
Orthologs
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Genomic context

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See USP28 in Genome Data Viewer
Location:
11q23.2
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (113797875..113875572, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (113808211..113885899, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113668597..113746294, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A13, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3911 Neighboring gene activating transcription factor 4 pseudogene 4 Neighboring gene ISG20L2 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:113720382-113720923 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:113720924-113721464 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:113721465-113722005 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:113722006-113722545 Neighboring gene RNA, U6 small nuclear 1107, pseudogene Neighboring gene U7 small nuclear RNA Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:113744182-113744682 Neighboring gene Sharpr-MPRA regulatory region 42 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113746853-113747514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113752951-113753737 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113756096-113756882 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:113766496-113766696 Neighboring gene 5-hydroxytryptamine receptor 3B Neighboring gene ReSE screen-validated silencer GRCh37_chr11:113813804-113813933 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:113822687-113823240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113827432-113828317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113835585-113836084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113845393-113846054 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113846055-113846714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113859815-113860316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:113860317-113860816 Neighboring gene 5-hydroxytryptamine receptor 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K. Prieto-Garcia C, et al. Mol Oncol, 2022 Sep. PMID 35364627, Free PMC Article
  2. USP28 regulates deubiquitination of histone H2A and cell proliferation. Li F, et al. Exp Cell Res, 2019 Jun 1. PMID 30910399
  3. Knockdown of USP28 enhances the radiosensitivity of esophageal cancer cells via the c-Myc/hypoxia-inducible factor-1 alpha pathway. Weili Z, et al. J Cell Biochem, 2019 Jan. PMID 30206969
  4. Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines. Zhou W, et al. Aging (Albany NY), 2023 Jul 13. PMID 37450415, Free PMC Article
  5. USP28 is a potential prognostic marker for bladder cancer. Guo G, et al. Tumour Biol, 2014 May. PMID 24347490

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage.
    Title: The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage.
  2. Control of cell proliferation by memories of mitosis.
    Title: Control of cell proliferation by memories of mitosis.
  3. USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells.
    Title: USP28 promotes tumorigenesis and cisplatin resistance by deubiquitinating MAST1 protein in cancer cells.
  4. The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells.
    Title: The deubiquitinase USP28 maintains the expression of the transcription factor MYCN and is essential in neuroblastoma cells.
  5. Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines.
    Title: Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines.
  6. Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.
    Title: Inhibition of deubiquitinase USP28 attenuates cyst growth in autosomal dominant polycystic kidney disease.
  7. USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
    Title: USP28 enables oncogenic transformation of respiratory cells, and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
  8. The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells.
    Title: The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells.
  9. Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.
    Title: Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling.
  10. USP28 promotes aerobic glycolysis of colorectal cancer by increasing stability of FOXC1.
    Title: USP28 promotes aerobic glycolysis of colorectal cancer by increasing stability of FOXC1.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA1515

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
  
enables deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
  
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ionizing radiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 28
Names
deubiquitinating enzyme 28
ubiquitin thioesterase 28
ubiquitin thiolesterase 28
ubiquitin-specific-processing protease 28
NP_001287958.1
NP_001333181.1
NP_001333182.1
NP_001333183.1
NP_001333184.1
NP_001333186.1
NP_001333187.1
NP_001333188.1
NP_001333189.1
NP_001333190.1
NP_001333191.1
NP_001333192.1
NP_001333193.1
NP_001333194.1
NP_001333196.1
NP_001333197.1
NP_001333198.1
NP_001333199.1
NP_001333200.1
NP_001333201.1
NP_001333202.1
NP_001387713.1
NP_001387714.1
NP_001387715.1
NP_001387716.1
NP_001387717.1
NP_001387718.1
NP_001387719.1
NP_001387720.1
NP_001387721.1
NP_001387722.1
NP_001387723.1
NP_001387724.1
NP_001387725.1
NP_001387726.1
NP_001387728.1
NP_001387729.1
NP_001387730.1
NP_001387731.1
NP_001387732.1
NP_001387733.1
NP_001387734.1
NP_001387735.1
NP_001387736.1
NP_001387738.1
NP_001387739.1
NP_001387740.1
NP_001387741.1
NP_001387742.1
NP_065937.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051668.1 RefSeqGene

    Range
    4999..82696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001301029.2 → NP_001287958.1  ubiquitin carboxyl-terminal hydrolase 28 isoform b

    See identical proteins and their annotated locations for NP_001287958.1

    Status: REVIEWED

    Source sequence(s)
    AK304770, AP001874, AP003170, BC035986, BF434481, DB061316
    Consensus CDS
    CCDS73394.1
    UniProtKB/TrEMBL
    B4E3L3, G3V1N5
    Related
    ENSP00000444991.1, ENST00000545540.5
    Conserved Domains (3) summary
    cd02665
    Location:38 → 523
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:38 → 142
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:36 → 273
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. NM_001346252.4 → NP_001333181.1  ubiquitin carboxyl-terminal hydrolase 28 isoform c

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544
    Consensus CDS
    CCDS91596.1
    UniProtKB/TrEMBL
    A0A8V8TLZ9
    Related
    ENSP00000513009.1, ENST00000696973.1

  3. NM_001346253.2 → NP_001333182.1  ubiquitin carboxyl-terminal hydrolase 28 isoform d

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  4. NM_001346254.2 → NP_001333183.1  ubiquitin carboxyl-terminal hydrolase 28 isoform e

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  5. NM_001346255.2 → NP_001333184.1  ubiquitin carboxyl-terminal hydrolase 28 isoform f

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  6. NM_001346257.2 → NP_001333186.1  ubiquitin carboxyl-terminal hydrolase 28 isoform g

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  7. NM_001346258.2 → NP_001333187.1  ubiquitin carboxyl-terminal hydrolase 28 isoform h

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/Swiss-Prot
    Q96RU2

  8. NM_001346259.2 → NP_001333188.1  ubiquitin carboxyl-terminal hydrolase 28 isoform i

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544
    Conserved Domains (3) summary
    COG5207
    Location:136 → 608
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02665
    Location:137 → 622
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd20487
    Location:740 → 1019
    USP28_C; carboxyl-terminal domain of ubiquitin-specific protease 28 (USP28)

  9. NM_001346260.2 → NP_001333189.1  ubiquitin carboxyl-terminal hydrolase 28 isoform j

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  10. NM_001346261.2 → NP_001333190.1  ubiquitin carboxyl-terminal hydrolase 28 isoform k

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  11. NM_001346262.2 → NP_001333191.1  ubiquitin carboxyl-terminal hydrolase 28 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AP001874, AP003170, KF459544
    Consensus CDS
    CCDS73394.1
    UniProtKB/TrEMBL
    B4E3L3, G3V1N5

  12. NM_001346263.2 → NP_001333192.1  ubiquitin carboxyl-terminal hydrolase 28 isoform l

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  13. NM_001346264.2 → NP_001333193.1  ubiquitin carboxyl-terminal hydrolase 28 isoform m

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  14. NM_001346265.2 → NP_001333194.1  ubiquitin carboxyl-terminal hydrolase 28 isoform n

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  15. NM_001346267.2 → NP_001333196.1  ubiquitin carboxyl-terminal hydrolase 28 isoform o

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform o.
    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  16. NM_001346268.2 → NP_001333197.1  ubiquitin carboxyl-terminal hydrolase 28 isoform o

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform o.
    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  17. NM_001346269.2 → NP_001333198.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 19 and 20, encodes isoform p.
    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  18. NM_001346270.2 → NP_001333199.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 18 and 20, encodes isoform p.
    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  19. NM_001346271.2 → NP_001333200.1  ubiquitin carboxyl-terminal hydrolase 28 isoform p

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 18 and 19, encodes isoform p.
    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  20. NM_001346272.2 → NP_001333201.1  ubiquitin carboxyl-terminal hydrolase 28 isoform q

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544
    UniProtKB/TrEMBL
    G3V1N5

  21. NM_001346273.2 → NP_001333202.1  ubiquitin carboxyl-terminal hydrolase 28 isoform r

    Status: REVIEWED

    Source sequence(s)
    AP001874, BC065928, DB061316
    Consensus CDS
    CCDS86248.1
    UniProtKB/Swiss-Prot
    Q96RU2
    Related
    ENSP00000445743.1, ENST00000537706.5
    Conserved Domains (3) summary
    cd02665
    Location:163 → 397
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14355
    Location:23 → 64
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:163 → 267
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

  22. NM_001400784.1 → NP_001387713.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  23. NM_001400785.1 → NP_001387714.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  24. NM_001400786.1 → NP_001387715.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  25. NM_001400787.1 → NP_001387716.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  26. NM_001400788.1 → NP_001387717.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  27. NM_001400789.1 → NP_001387718.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  28. NM_001400790.1 → NP_001387719.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  29. NM_001400791.1 → NP_001387720.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 27

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  30. NM_001400792.1 → NP_001387721.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  31. NM_001400793.1 → NP_001387722.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  32. NM_001400794.1 → NP_001387723.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170

  33. NM_001400795.1 → NP_001387724.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  34. NM_001400796.1 → NP_001387725.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  35. NM_001400797.1 → NP_001387726.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 33

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  36. NM_001400799.1 → NP_001387728.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 34

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  37. NM_001400800.1 → NP_001387729.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  38. NM_001400801.1 → NP_001387730.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544
    Related
    ENSP00000442431.1, ENST00000544967.5

  39. NM_001400802.1 → NP_001387731.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  40. NM_001400803.1 → NP_001387732.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  41. NM_001400804.1 → NP_001387733.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  42. NM_001400805.1 → NP_001387734.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 38

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  43. NM_001400806.1 → NP_001387735.1  ubiquitin carboxyl-terminal hydrolase 28 isoform q

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  44. NM_001400807.1 → NP_001387736.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 35

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  45. NM_001400809.1 → NP_001387738.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 40

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  46. NM_001400810.1 → NP_001387739.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 41

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  47. NM_001400811.1 → NP_001387740.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  48. NM_001400812.1 → NP_001387741.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 42

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  49. NM_001400813.1 → NP_001387742.1  ubiquitin carboxyl-terminal hydrolase 28 isoform 36

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

  50. NM_020886.4 → NP_065937.1  ubiquitin carboxyl-terminal hydrolase 28 isoform a

    See identical proteins and their annotated locations for NP_065937.1

    Status: REVIEWED

    Source sequence(s)
    AF266283, AP001874, AP003170, BC035986, BF434481, DB061316
    Consensus CDS
    CCDS31680.1
    UniProtKB/Swiss-Prot
    B0YJC0, B0YJC1, Q6NZX9, Q96RU2, Q9P213
    Related
    ENSP00000003302.4, ENST00000003302.8
    Conserved Domains (4) summary
    cd02665
    Location:163 → 648
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14355
    Location:23 → 64
    UBA_UBP28; UBA domain found in ubiquitin carboxyl-terminal hydrolase 28 (UBP28) and similar proteins
    cl02553
    Location:163 → 267
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:161 → 398
    UCH; Ubiquitin carboxyl-terminal hydrolase

RNA

  1. NR_174609.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP001874, AP003170, KF459544

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    113797875..113875572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    113808211..113885899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RU2.1 GenPept UniProtKB/Swiss-Prot:Q96RU2

Gene LinkOut

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