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FNIP2 folliculin interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 57600, updated on 2-Nov-2024

Summary

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Official Symbol
FNIP2provided by HGNC
Official Full Name
folliculin interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:29280
See related
Ensembl:ENSG00000052795 MIM:612768; AllianceGenome:HGNC:29280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FNIPL; MAPO1
Summary
This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
Expression
Ubiquitous expression in kidney (RPKM 11.0), fat (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

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See FNIP2 in Genome Data Viewer
Location:
4q32.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (158769026..158908050)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (162119774..162258820)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159690178..159829202)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U3 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene hESC enhancers GRCh37_chr4:159643958-159644541 and GRCh37_chr4:159644542-159645126 Neighboring gene peptidylprolyl isomerase D Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15773 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:159690086-159690823 Neighboring gene Sharpr-MPRA regulatory region 12747 Neighboring gene RNA, U6 small nuclear 128, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:159766516-159767164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159802306-159803286 Neighboring gene Sharpr-MPRA regulatory region 14183 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159823055-159823920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159823921-159824786 Neighboring gene uncharacterized LOC124900178 Neighboring gene sperm microtubule inner protein 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:159917411-159918610 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:159927373-159927905 Neighboring gene proteasome activator subunit 2 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis. Sano S, et al. Biochem Biophys Res Commun, 2013 Jan 11. PMID 23201403
  2. Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region. Fernández LP, et al. Genome Biol, 2022 Oct 31. PMID 36316722, Free PMC Article
  3. A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA. Komori K, et al. Oncogene, 2009 Feb 26. PMID 19137017
  4. Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells. Glykofridis IE, et al. Elife, 2021 Jan 18. PMID 33459596, Free PMC Article
  5. Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression. Nagashima K, et al. Oncotarget, 2017 Feb 7. PMID 28039480, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
    Title: Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
  2. Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region.
    Title: Folliculin-interacting protein FNIP2 impacts on overweight and obesity through a polymorphism in a conserved 3' untranslated region.
  3. Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells.
    Title: Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cells.
  4. SCFbeta-TRCP negatively regulates the FLCN complex by promoting FNIP2 degradation in Birt-Hogg-Dube syndrome-associated renal cancer.
    Title: Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN complex localization and promotes renal cancer progression.
  5. this study obtained evidence to show that stabilization of MAPO1 is regulated through its specific interaction with folliculin and AMPK.
    Title: Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. The identification and characterization of a novel FNIP1 homolog FNIP2 that also interacts with FLCN and AMPK, is reported.
    Title: Identification and characterization of a novel folliculin-interacting protein FNIP2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
folliculin-interacting protein 2
Names
FNIP1-like protein
O6-methylguanine-induced apoptosis 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323916.2 → NP_001310845.1  folliculin-interacting protein 2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AB040883, AC093700, AC107219, BC016638
    UniProtKB/Swiss-Prot
    Q9P278
    Conserved Domains (3) summary
    pfam14636
    Location:69 → 187
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:320 → 553
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:950 → 1133
    FNIP_C; Folliculin-interacting protein C-terminus

  2. NM_001346043.2 → NP_001332972.1  folliculin-interacting protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB040883, AC093700, BM806956, HY049314
    UniProtKB/Swiss-Prot
    Q9P278

  3. NM_001366843.1 → NP_001353772.1  folliculin-interacting protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC093700, AC107219, AC109823
    Conserved Domains (3) summary
    pfam14636
    Location:69 → 187
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:350 → 583
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:980 → 1163
    FNIP_C; Folliculin-interacting protein C-terminus

  4. NM_020840.3 → NP_065891.1  folliculin-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_065891.1

    Status: REVIEWED

    Source sequence(s)
    AB040883, AC093700, HY049314
    Consensus CDS
    CCDS47155.1
    UniProtKB/Swiss-Prot
    Q05DC3, Q96I31, Q9H994, Q9P278
    Related
    ENSP00000264433.6, ENST00000264433.11
    Conserved Domains (3) summary
    pfam14636
    Location:46 → 164
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:297 → 530
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:927 → 1110
    FNIP_C; Folliculin-interacting protein C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    158769026..158908050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263158.3 → XP_005263215.1  folliculin-interacting protein 2 isoform X2

    Conserved Domains (3) summary
    pfam14636
    Location:46 → 164
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:327 → 560
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:957 → 1140
    FNIP_C; Folliculin-interacting protein C-terminus

  2. XM_047416018.1 → XP_047271974.1  folliculin-interacting protein 2 isoform X5

  3. XM_017008487.2 → XP_016863976.1  folliculin-interacting protein 2 isoform X1

  4. XM_047416017.1 → XP_047271973.1  folliculin-interacting protein 2 isoform X4

  5. XM_024454161.2 → XP_024309929.1  folliculin-interacting protein 2 isoform X6

    Conserved Domains (3) summary
    pfam14636
    Location:69 → 187
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:350 → 583
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:980 → 1036
    FNIP_C; Folliculin-interacting protein C-terminus

  6. XM_047416021.1 → XP_047271977.1  folliculin-interacting protein 2 isoform X8

  7. XM_005263160.4 → XP_005263217.1  folliculin-interacting protein 2 isoform X3

    Conserved Domains (3) summary
    pfam14636
    Location:69 → 187
    FNIP_N; Folliculin-interacting protein N-terminus
    pfam14637
    Location:350 → 583
    FNIP_M; Folliculin-interacting protein middle domain
    pfam14638
    Location:980 → 1036
    FNIP_C; Folliculin-interacting protein C-terminus

  8. XM_047416019.1 → XP_047271975.1  folliculin-interacting protein 2 isoform X7

  9. XM_047416022.1 → XP_047271978.1  folliculin-interacting protein 2 isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    162119774..162258820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350604.1 → XP_054206579.1  folliculin-interacting protein 2 isoform X2

  2. XM_054350607.1 → XP_054206582.1  folliculin-interacting protein 2 isoform X5

  3. XM_054350603.1 → XP_054206578.1  folliculin-interacting protein 2 isoform X1

  4. XM_054350606.1 → XP_054206581.1  folliculin-interacting protein 2 isoform X4

  5. XM_054350608.1 → XP_054206583.1  folliculin-interacting protein 2 isoform X6

  6. XM_054350611.1 → XP_054206586.1  folliculin-interacting protein 2 isoform X8

  7. XM_054350605.1 → XP_054206580.1  folliculin-interacting protein 2 isoform X3

  8. XM_054350609.1 → XP_054206584.1  folliculin-interacting protein 2 isoform X7

  9. XM_054350610.1 → XP_054206585.1  folliculin-interacting protein 2 isoform X10

  10. XM_054350612.1 → XP_054206587.1  folliculin-interacting protein 2 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P278.2 GenPept UniProtKB/Swiss-Prot:Q9P278

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