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KCTD16 potassium channel tetramerization domain containing 16 [ Homo sapiens (human) ]

Gene ID: 57528, updated on 3-Apr-2024

Summary

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Official Symbol
KCTD16provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 16provided by HGNC
Primary source
HGNC:HGNC:29244
See related
Ensembl:ENSG00000183775 MIM:613423; AllianceGenome:HGNC:29244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in protein homooligomerization. Predicted to act upstream of or within regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cell projection. Predicted to be part of receptor complex. Predicted to be active in postsynaptic membrane and presynaptic membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 4.6), lung (RPKM 0.4) and 3 other tissues See more
Orthologs
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Genomic context

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Location:
5q31.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (144170873..144485686)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (144702911..145017831)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (143550437..143865249)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 87, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:143543592-143544791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23355 Neighboring gene Yip1 domain family member 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:143677189-143677923 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:143697432-143697944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23357 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:143762205-143763404 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 5 Neighboring gene NANOG hESC enhancer GRCh37_chr5:143867216-143867717 Neighboring gene 60S ribosomal protein L9-like Neighboring gene RN7SK pseudogene 246

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Structural basis for auxiliary subunit KCTD16 regulation of the GABA(B) receptor. Zuo H, et al. Proc Natl Acad Sci U S A, 2019 Apr 23. PMID 30971491, Free PMC Article
  2. Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein. Yu Y, et al. Neurosci Bull, 2016 Apr. PMID 26960425, Free PMC Article
  3. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Xie T, et al. Neurobiol Aging, 2014 Jul. PMID 24529757
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2000 Feb 28. PMID 10718198
  5. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1317, MGC138167, DKFZp781A1155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD16
Names
potassium channel tetramerisation domain containing 16
potassium channel tetramerization domain-containing protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370486.1 → NP_001357415.1  BTB/POZ domain-containing protein KCTD16

    Status: VALIDATED

    Source sequence(s)
    AC008383, AC008716
    Consensus CDS
    CCDS34260.1
    UniProtKB/Swiss-Prot
    Q68DU8, Q9P2M9
    UniProtKB/TrEMBL
    A8K8W2
    Related
    ENSP00000426548.1, ENST00000507359.3
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

  2. NM_001370487.1 → NP_001357416.1  BTB/POZ domain-containing protein KCTD16

    Status: VALIDATED

    Source sequence(s)
    AC008383, AC008716
    Consensus CDS
    CCDS34260.1
    UniProtKB/Swiss-Prot
    Q68DU8, Q9P2M9
    UniProtKB/TrEMBL
    A8K8W2
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

  3. NM_020768.4 → NP_065819.1  BTB/POZ domain-containing protein KCTD16

    See identical proteins and their annotated locations for NP_065819.1

    Status: VALIDATED

    Source sequence(s)
    AC008716, AK292477
    Consensus CDS
    CCDS34260.1
    UniProtKB/Swiss-Prot
    Q68DU8, Q9P2M9
    UniProtKB/TrEMBL
    A8K8W2
    Related
    ENSP00000424151.1, ENST00000512467.6
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    144170873..144485686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417449.1 → XP_047273405.1  BTB/POZ domain-containing protein KCTD16 isoform X2

  2. XM_005268493.3 → XP_005268550.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    See identical proteins and their annotated locations for XP_005268550.1

    UniProtKB/Swiss-Prot
    Q68DU8, Q9P2M9
    UniProtKB/TrEMBL
    A8K8W2
    Conserved Domains (2) summary
    cd18398
    Location:23 → 125
    BTB_POZ_KCTD16; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 16 (KCTD16)
    cd22219
    Location:160 → 280
    H1_KCTD16; H1 domain found in potassium channel tetramerization domain-containing protein 16

  3. XM_011537673.3 → XP_011535975.1  BTB/POZ domain-containing protein KCTD16 isoform X2

    Conserved Domains (2) summary
    smart00225
    Location:27 → 121
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cl02518
    Location:27 → 118
    BTB; BTB/POZ domain

  4. XM_047417450.1 → XP_047273406.1  BTB/POZ domain-containing protein KCTD16 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    144702911..145017831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444576.1 → XP_047300532.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    UniProtKB/Swiss-Prot
    Q68DU8, Q9P2M9

  2. XM_047444580.1 → XP_047300536.1  BTB/POZ domain-containing protein KCTD16 isoform X2

  3. XM_047444581.1 → XP_047300537.1  BTB/POZ domain-containing protein KCTD16 isoform X2

  4. XM_047444577.1 → XP_047300533.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    UniProtKB/Swiss-Prot
    Q68DU8, Q9P2M9

  5. XM_047444575.1 → XP_047300531.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    UniProtKB/Swiss-Prot
    Q68DU8, Q9P2M9

  6. XM_047444578.1 → XP_047300534.1  BTB/POZ domain-containing protein KCTD16 isoform X1

    UniProtKB/Swiss-Prot
    Q68DU8, Q9P2M9

  7. XM_047444579.1 → XP_047300535.1  BTB/POZ domain-containing protein KCTD16 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68DU8.1 GenPept UniProtKB/Swiss-Prot:Q68DU8

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