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INTS2 integrator complex subunit 2 [ Homo sapiens (human) ]

Gene ID: 57508, updated on 5-Mar-2024

Summary

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Official Symbol
INTS2provided by HGNC
Official Full Name
integrator complex subunit 2provided by HGNC
Primary source
HGNC:HGNC:29241
See related
Ensembl:ENSG00000108506 MIM:611346; AllianceGenome:HGNC:29241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT2; KIAA1287
Summary
INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 3.6), lymph node (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

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See INTS2 in Genome Data Viewer
Location:
17q23.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (61865367..61927982, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (62734308..62796936, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (59942728..60005343, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 7395 Neighboring gene nascent polypeptide associated complex subunit alpha 2 Neighboring gene BRCA1 interacting helicase 1 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:59835525-59836270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12535 Neighboring gene VISTA enhancer hs778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8802 Neighboring gene mediator complex subunit 13 Neighboring gene RNA, 7SL, cytoplasmic 800, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60114488-60114673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12537 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8804 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:60178273-60178878 Neighboring gene NANOG hESC enhancer GRCh37_chr17:60183965-60184527 Neighboring gene NANOG hESC enhancer GRCh37_chr17:60198431-60198956 Neighboring gene RNA polymerase mitochondrial pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrator complex and transcription regulation: Recent findings and pathophysiology. Rienzo M, et al. Biochim Biophys Acta, 2016 Oct. PMID 27427483
  2. Integrator: surprisingly diverse functions in gene expression. Baillat D, et al. Trends Biochem Sci, 2015 May. PMID 25882383, Free PMC Article
  3. Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites. Lim B, et al. Oncotarget, 2016 Feb 16. PMID 26811494, Free PMC Article
  4. Structure of the catalytic core of the Integrator complex. Pfleiderer MM, et al. Mol Cell, 2021 Mar 18. PMID 33548203, Free PMC Article
  5. The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts. Beckedorff F, et al. Cell Rep, 2020 Jul 21. PMID 32697989, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation in INTS2 gene is associated with gastric cancer peritoneal carcinomatosis.
    Title: Genetic alterations and their clinical implications in gastric cancer peritoneal carcinomatosis revealed by whole-exome sequencing of malignant ascites.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with INTS2 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane HDA PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
integrator complex subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330417.2 → NP_001317346.2  integrator complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC060798
    Consensus CDS
    CCDS82181.1
    UniProtKB/TrEMBL
    B4DQZ5, J3KMZ7
    Related
    ENSP00000496407.1, ENST00000647009.1
    Conserved Domains (1) summary
    pfam14750
    Location:26 → 1129
    INTS2; Integrator complex subunit 2

  2. NM_001351695.2 → NP_001338624.2  integrator complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC060798
    Consensus CDS
    CCDS82181.1
    UniProtKB/TrEMBL
    B4DQZ5, J3KMZ7
    Related
    ENSP00000251334.6, ENST00000251334.7
    Conserved Domains (1) summary
    pfam14750
    Location:26 → 1129
    INTS2; Integrator complex subunit 2

  3. NM_020748.4 → NP_065799.2  integrator complex subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC060798
    Consensus CDS
    CCDS45750.1
    UniProtKB/Swiss-Prot
    Q9H0H0, Q9ULD3
    UniProtKB/TrEMBL
    B4DQZ5
    Related
    ENSP00000414237.3, ENST00000444766.7
    Conserved Domains (1) summary
    pfam14750
    Location:34 → 1137
    INTS2; Integrator complex subunit 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    61865367..61927982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_934509.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    62734308..62796936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008484865.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H0H0.2 GenPept UniProtKB/Swiss-Prot:Q9H0H0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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