U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF608 zinc finger protein 608 [ Homo sapiens (human) ]

Gene ID: 57507, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF608provided by HGNC
Official Full Name
zinc finger protein 608provided by HGNC
Primary source
HGNC:HGNC:29238
See related
Ensembl:ENSG00000168916 AllianceGenome:HGNC:29238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NY-REN-36
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung (RPKM 4.4), testis (RPKM 4.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5q23.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (124636915..124748824, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (125153362..125265304, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (123972608..124084517, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1170 Neighboring gene uncharacterized LOC107986448 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123644150-123645142 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_80867 Neighboring gene uncharacterized LOC105379155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16277 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:123777990-123778496 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:123804163-123805004 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123832600-123833191 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:123833192-123833782 Neighboring gene NANOG hESC enhancer GRCh37_chr5:123837876-123838461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23009 Neighboring gene NANOG hESC enhancer GRCh37_chr5:123890213-123891101 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:123935182-123935396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23010 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23011 Neighboring gene Sharpr-MPRA regulatory region 9682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:123984206-123984714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23012 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:123995996-123996689 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:123998129-123998646 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:124044787-124045526 Neighboring gene NANOG hESC enhancer GRCh37_chr5:124068918-124069490 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:124073123-124073732 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:124074341-124074948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23013 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:124077846-124078540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:124079931-124080624 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:124082573-124083571 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:124083572-124084570 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:124086863-124087461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16279 Neighboring gene uncharacterized LOC105379156 Neighboring gene ribosomal protein L28 pseudogene 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese. Ma RC, et al. PLoS One, 2014. PMID 24465431, Free PMC Article
  2. Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells. Báez-Vega PM, et al. Oncotarget, 2016 Jun 14. PMID 27166999, Free PMC Article
  3. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Graff M, et al. Hum Mol Genet, 2013 Sep 1. PMID 23669352, Free PMC Article
  4. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. Kerns SL, et al. Int J Radiat Oncol Biol Phys, 2010 Dec 1. PMID 20932654, Free PMC Article
  5. BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility. Manjur ABMK, et al. J Steroid Biochem Mol Biol, 2021 Jun. PMID 33722704

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
EBI GWAS Catalog
Familial young-onset diabetes, pre-diabetes and cardiovascular disease are associated with genetic variants of DACH1 in Chinese.
EBI GWAS Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC166851, DKFZp781C0723

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 608
Names
renal carcinoma antigen NY-REN-36

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385619.1 → NP_001372548.1  zinc finger protein 608 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC112196, AC113398
    Consensus CDS
    CCDS34219.1
    UniProtKB/Swiss-Prot
    A7E2W9, Q3SYM6, Q68D12, Q8IY05, Q9ULD9, Q9Y5A1
    Related
    ENSP00000307746.5, ENST00000306315.9
    Conserved Domains (2) summary
    COG5189
    Location:512 → 593
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:1103 → 1317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  2. NM_001385620.1 → NP_001372549.1  zinc finger protein 608 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC112196, AC113398
    Conserved Domains (2) summary
    COG5189
    Location:512 → 593
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:1103 → 1317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  3. NM_001385621.1 → NP_001372550.1  zinc finger protein 608 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC112196, AC113398
    Conserved Domains (2) summary
    COG5189
    Location:224 → 305
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:815 → 1029
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  4. NM_020747.3 → NP_065798.2  zinc finger protein 608 isoform 1

    See identical proteins and their annotated locations for NP_065798.2

    Status: VALIDATED

    Source sequence(s)
    AC112196, AC113398
    Consensus CDS
    CCDS34219.1
    UniProtKB/Swiss-Prot
    A7E2W9, Q3SYM6, Q68D12, Q8IY05, Q9ULD9, Q9Y5A1
    Related
    ENSP00000421899.2, ENST00000513986.2
    Conserved Domains (2) summary
    COG5189
    Location:512 → 593
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:1103 → 1317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    124636915..124748824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417448.1 → XP_047273404.1  zinc finger protein 608 isoform X5

    Related
    ENSP00000427657.1, ENST00000504926.5

  2. XM_011543522.4 → XP_011541824.1  zinc finger protein 608 isoform X2

    Conserved Domains (2) summary
    COG5189
    Location:215 → 296
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:806 → 1020
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  3. XM_011543523.3 → XP_011541825.1  zinc finger protein 608 isoform X4

    Conserved Domains (2) summary
    COG5189
    Location:127 → 208
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:718 → 932
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  4. XM_011543520.4 → XP_011541822.1  zinc finger protein 608 isoform X1

    Conserved Domains (2) summary
    COG5189
    Location:512 → 593
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    PTZ00108
    Location:1103 → 1317
    PTZ00108; DNA topoisomerase 2-like protein; Provisional

  5. XM_047417447.1 → XP_047273403.1  zinc finger protein 608 isoform X3

  6. XM_047417446.1 → XP_047273402.1  zinc finger protein 608 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    125153362..125265304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353006.1 → XP_054208981.1  zinc finger protein 608 isoform X2

  2. XM_054353009.1 → XP_054208984.1  zinc finger protein 608 isoform X4

  3. XM_054353005.1 → XP_054208980.1  zinc finger protein 608 isoform X1

  4. XM_054353008.1 → XP_054208983.1  zinc finger protein 608 isoform X3

  5. XM_054353007.1 → XP_054208982.1  zinc finger protein 608 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULD9.4 GenPept UniProtKB/Swiss-Prot:Q9ULD9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous