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ODF2L outer dense fiber of sperm tails 2 like [ Homo sapiens (human) ]

Gene ID: 57489, updated on 5-Mar-2024

Summary

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Official Symbol
ODF2Lprovided by HGNC
Official Full Name
outer dense fiber of sperm tails 2 likeprovided by HGNC
Primary source
HGNC:HGNC:29225
See related
Ensembl:ENSG00000122417 MIM:620130; AllianceGenome:HGNC:29225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in negative regulation of cilium assembly. Located in centriolar satellite and ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 2.6), lung (RPKM 2.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p22.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (86346837..86396323, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (86186869..86236344, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (86812520..86862006, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2795 Neighboring gene uncharacterized LOC105378825 Neighboring gene microRNA 7856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1276 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:86875355-86875998 Neighboring gene RPL7L1 pseudogene 22 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_9486 Neighboring gene chloride channel accessory 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models. Li J, et al. J Clin Invest, 2023 Jan 17. PMID 36378528, Free PMC Article
  2. Identification of BCAP, a new protein associated with basal bodies and centrioles. Ponsard C, et al. Front Biosci, 2007 May 1. PMID 17485331
  3. BCAP is a centriolar satellite protein and inhibitor of ciliogenesis. de Saram P, et al. J Cell Sci, 2017 Oct 1. PMID 28775150
  4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462
  5. Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins. Dho SE, et al. Sci Rep, 2019 Aug 28. PMID 31462741, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models.
    Title: ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1229, MGC111060

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cilium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein BCAP
Names
ODF2-like protein
basal body centriole-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007022.4 → NP_001007023.2  protein BCAP isoform b

    See identical proteins and their annotated locations for NP_001007023.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform b) that maintains the reading frame but is longer than isoform a.
    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS41354.2
    UniProtKB/Swiss-Prot
    A8MU56, B4E037, Q05C40, Q5BJG5, Q5TBX3, Q5TBX4, Q86X31, Q9ULJ1
    UniProtKB/TrEMBL
    B4DZ83
    Related
    ENSP00000359600.2, ENST00000359242.7
    Conserved Domains (1) summary
    COG1196
    Location:377 → 621
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_001184765.2 → NP_001171694.1  protein BCAP isoform c

    See identical proteins and their annotated locations for NP_001171694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform c) has a distinct C-terminus but is the same length as isoform a.
    Source sequence(s)
    AK303209, AL136382, BC047368, BC091490, BX499763, CD687053
    UniProtKB/TrEMBL
    B4DZ83
    Conserved Domains (2) summary
    COG1196
    Location:41 → 315
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:384 → 618
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_001184766.2 → NP_001171695.1  protein BCAP isoform d

    See identical proteins and their annotated locations for NP_001171695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK303209, AL136382, BC047368, BX499763, CD687053
    Consensus CDS
    CCDS53339.1
    UniProtKB/TrEMBL
    B4DZ83
    Related
    ENSP00000359597.2, ENST00000370566.7
    Conserved Domains (1) summary
    COG1196
    Location:243 → 543
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. NM_001366779.1 → NP_001353708.1  protein BCAP isoform e

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:192 → 495
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. NM_001366781.1 → NP_001353710.1  protein BCAP isoform f

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS90997.1
    UniProtKB/TrEMBL
    B4DZ83
    Related
    ENSP00000433092.2, ENST00000460698.7
    Conserved Domains (1) summary
    cl25732
    Location:323 → 626
    SMC_N; RecF/RecN/SMC N terminal domain

  6. NM_001366782.1 → NP_001353711.1  protein BCAP isoform e

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:192 → 495
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. NM_001366783.2 → NP_001353712.1  protein BCAP isoform g

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    B4DZ83
    Related
    ENSP00000512548.1, ENST00000696310.1
    Conserved Domains (1) summary
    cl25732
    Location:323 → 592
    SMC_N; RecF/RecN/SMC N terminal domain

  8. NM_001366784.1 → NP_001353713.1  protein BCAP isoform f

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS90997.1
    UniProtKB/TrEMBL
    B4DZ83
    Related
    ENSP00000512541.1, ENST00000696303.1
    Conserved Domains (1) summary
    cl25732
    Location:323 → 626
    SMC_N; RecF/RecN/SMC N terminal domain

  9. NM_001395519.1 → NP_001382448.1  protein BCAP isoform h

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    B4DZ83
    Conserved Domains (1) summary
    COG1196
    Location:284 → 587
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  10. NM_001395520.1 → NP_001382449.1  protein BCAP isoform h

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    B4DZ83
    Conserved Domains (1) summary
    COG1196
    Location:284 → 587
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. NM_001395521.1 → NP_001382450.1  protein BCAP isoform d

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS53339.1
    UniProtKB/TrEMBL
    B4DZ83
    Conserved Domains (1) summary
    COG1196
    Location:243 → 543
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. NM_001395522.1 → NP_001382451.1  protein BCAP isoform i

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    B4DZ83
    Conserved Domains (1) summary
    COG1196
    Location:243 → 543
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  13. NM_001395523.1 → NP_001382452.1  protein BCAP isoform j

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    B4DZ83
    Conserved Domains (1) summary
    COG1196
    Location:204 → 504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  14. NM_001395524.1 → NP_001382453.1  protein BCAP isoform j

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    B4DZ83
    Conserved Domains (1) summary
    COG1196
    Location:204 → 504
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  15. NM_001395525.1 → NP_001382454.1  protein BCAP isoform e

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:192 → 495
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  16. NM_001395526.1 → NP_001382455.1  protein BCAP isoform e

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Related
    ENSP00000512542.1, ENST00000696304.1
    Conserved Domains (1) summary
    COG1196
    Location:192 → 495
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  17. NM_001395527.1 → NP_001382456.1  protein BCAP isoform e

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:192 → 495
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  18. NM_001395528.1 → NP_001382457.1  protein BCAP isoform e

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:192 → 495
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  19. NM_001395529.1 → NP_001382458.1  protein BCAP isoform k

    Status: VALIDATED

    Source sequence(s)
    AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (2) summary
    COG1196
    Location:165 → 486
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:34 → 245
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  20. NM_001395530.1 → NP_001382459.1  protein BCAP isoform l

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (2) summary
    TIGR02168
    Location:253 → 487
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:51 → 417
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  21. NM_001395531.1 → NP_001382460.1  protein BCAP isoform l

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (2) summary
    TIGR02168
    Location:253 → 487
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:51 → 417
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  22. NM_001395532.1 → NP_001382461.1  protein BCAP isoform m

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    A0A8Q3SIE2
    Conserved Domains (1) summary
    COG1196
    Location:192 → 461
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  23. NM_001395533.1 → NP_001382462.1  protein BCAP isoform m

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    A0A8Q3SIE2
    Conserved Domains (1) summary
    COG1196
    Location:192 → 461
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  24. NM_001395534.1 → NP_001382463.1  protein BCAP isoform n

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS90996.1
    UniProtKB/TrEMBL
    A0A8Q3WMC5, H0YD68
    Related
    ENSP00000512536.1, ENST00000696297.1
    Conserved Domains (1) summary
    COG1196
    Location:112 → 412
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  25. NM_001395535.1 → NP_001382464.1  protein BCAP isoform n

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS90996.1
    UniProtKB/TrEMBL
    A0A8Q3WMC5, H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:112 → 412
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  26. NM_001395536.1 → NP_001382465.1  protein BCAP isoform n

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS90996.1
    UniProtKB/TrEMBL
    A0A8Q3WMC5, H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:112 → 412
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  27. NM_001395537.1 → NP_001382466.1  protein BCAP isoform n

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS90996.1
    UniProtKB/TrEMBL
    A0A8Q3WMC5, H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:112 → 412
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  28. NM_001395538.1 → NP_001382467.1  protein BCAP isoform o

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    A0A8Q3SIE2
    Conserved Domains (1) summary
    COG1196
    Location:153 → 422
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  29. NM_001395539.1 → NP_001382468.1  protein BCAP isoform o

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    A0A8Q3SIE2
    Conserved Domains (1) summary
    COG1196
    Location:153 → 422
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  30. NM_001395540.1 → NP_001382469.1  protein BCAP isoform p

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    A0A8Q3SIE2
    Conserved Domains (1) summary
    COG1196
    Location:112 → 412
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  31. NM_001395541.1 → NP_001382470.1  protein BCAP isoform q

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    UniProtKB/TrEMBL
    H0YD68
    Conserved Domains (1) summary
    COG1196
    Location:73 → 373
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  32. NM_001395542.1 → NP_001382471.1  protein BCAP isoform r

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Conserved Domains (1) summary
    TIGR02168
    Location:79 → 392
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  33. NM_001395543.1 → NP_001382472.1  protein BCAP isoform s

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Conserved Domains (1) summary
    COG1196
    Location:73 → 373
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  34. NM_001395544.1 → NP_001382473.1  protein BCAP isoform s

    Status: VALIDATED

    Source sequence(s)
    AC119749, AL136382
    Conserved Domains (1) summary
    COG1196
    Location:73 → 373
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  35. NM_020729.4 → NP_065780.2  protein BCAP isoform a

    See identical proteins and their annotated locations for NP_065780.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC119749, AL136382
    Consensus CDS
    CCDS30763.2
    UniProtKB/TrEMBL
    B4DZ83
    Related
    ENSP00000294678.2, ENST00000294678.6
    Conserved Domains (1) summary
    cl23720
    Location:307 → 420
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    86346837..86396323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    86186869..86236344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULJ1.2 GenPept UniProtKB/Swiss-Prot:Q9ULJ1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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