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CRACD capping protein inhibiting regulator of actin dynamics [ Homo sapiens (human) ]

Gene ID: 57482, updated on 3-Apr-2024

Summary

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Official Symbol
CRACDprovided by HGNC
Official Full Name
capping protein inhibiting regulator of actin dynamicsprovided by HGNC
Primary source
HGNC:HGNC:29219
See related
Ensembl:ENSG00000109265 MIM:618327; AllianceGenome:HGNC:29219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRAD; KIAA1211
Summary
Involved in negative regulation of barbed-end actin filament capping. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 12.2), small intestine (RPKM 8.0) and 13 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
4q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (56049098..56330609)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (59537287..59818577)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (56915264..57196775)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377663 Neighboring gene exocyst complex component 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:56786864-56788063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21575 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:56814688-56815652 Neighboring gene uncharacterized LOC124900705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21576 Neighboring gene centrosomal protein 135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:56915160-56915835 Neighboring gene VISTA enhancer hs1651 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:56952044-56952696 Neighboring gene RNA, 5S ribosomal pseudogene 161 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:57092588-57093151 Neighboring gene uncharacterized LOC101928760 Neighboring gene RNA, U6 small nuclear 197, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:57176503-57177702 Neighboring gene uncharacterized LOC124900707 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:57179040-57179540 Neighboring gene mitochondrial ribosomal protein L22 pseudogene 1 Neighboring gene RNA, 5S ribosomal pseudogene 162 Neighboring gene ribosomal protein L7a pseudogene 31 Neighboring gene aminoadipate-semialdehyde dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction. Chang Y, et al. Cell Rep, 2022 Feb 15. PMID 35172140
  2. Prognostic impact of tumor mutation burden and the mutation in KIAA1211 in small cell lung cancer. Zhou M, et al. Respir Res, 2019 Nov 7. PMID 31699089, Free PMC Article
  3. Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4. Cui A, et al. Biosci Rep, 2020 Oct 30. PMID 33006362, Free PMC Article
  4. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Jung YS, et al. Nat Cell Biol, 2018 Nov. PMID 30361697, Free PMC Article
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction.
    Title: Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction.
  2. Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4.
    Title: Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4.
  3. The overall survival of small cell lung cancer patients carrying KIAA1211 mutation was significantly longer than those with wild-type KIAA1211.
    Title: Prognostic impact of tumor mutation burden and the mutation in KIAA1211 in small cell lung cancer.
  4. Datam indicate that cancer-related regulator of actin dynamics (CRAD) as frequently mutated or transcriptionally downregulated and as a tumour suppressor in colorectal cancer (CRC).
    Title: Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin.
  5. CRAD (Cancer-related Regulator of Actin Dynamics, previously KIAA1211) binds to and inhibits capping proteins, which leads to actin polymerization. CRAD is ubiquitously expressed in epithelial cells and is required for the maintenance of epithelial cell integrity. Genetic ablation of this gene deregulates Wnt signaling and induces the development of tumors in mouse models.
    Title: Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564H1363

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in epithelial structure maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maintenance of gastrointestinal epithelium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of gastrointestinal epithelium ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of barbed-end actin filament capping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
capping protein-inhibiting regulator of actin dynamics
Names
cancer-related regulator of actin dynamics

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393381.1 → NP_001380310.1  capping protein-inhibiting regulator of actin dynamics isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620, AC092627
    Consensus CDS
    CCDS43230.1
    UniProtKB/Swiss-Prot
    Q6ZU35, Q9NTE2, Q9NTP8, Q9ULK9
    UniProtKB/TrEMBL
    B7ZMH1
    Related
    ENSP00000507165.1, ENST00000682029.1
    Conserved Domains (4) summary
    PTZ00121
    Location:219 → 526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:623 → 1060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:934 → 1217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  2. NM_001393382.1 → NP_001380311.1  capping protein-inhibiting regulator of actin dynamics isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620
    Consensus CDS
    CCDS43230.1
    UniProtKB/Swiss-Prot
    Q6ZU35, Q9NTE2, Q9NTP8, Q9ULK9
    UniProtKB/TrEMBL
    B7ZMH1
    Related
    ENSP00000423366.1, ENST00000504228.6
    Conserved Domains (4) summary
    PTZ00121
    Location:219 → 526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:623 → 1060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:934 → 1217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  3. NM_001393383.1 → NP_001380312.1  capping protein-inhibiting regulator of actin dynamics isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620, AC092627
    UniProtKB/TrEMBL
    B7ZMH1
    Conserved Domains (4) summary
    PTZ00121
    Location:161 → 468
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:565 → 1002
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:876 → 1159
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:3 → 114
    DUF4592; Domain of unknown function (DUF4592)

  4. NM_001393384.1 → NP_001380313.1  capping protein-inhibiting regulator of actin dynamics isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620, AC092627
    UniProtKB/TrEMBL
    B7ZMH1
    Conserved Domains (4) summary
    PTZ00121
    Location:161 → 468
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:565 → 1002
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:876 → 1159
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:3 → 114
    DUF4592; Domain of unknown function (DUF4592)

  5. NM_001393385.1 → NP_001380314.1  capping protein-inhibiting regulator of actin dynamics isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620
    UniProtKB/TrEMBL
    B7ZMH1
    Conserved Domains (4) summary
    PTZ00121
    Location:161 → 468
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:565 → 1002
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:876 → 1159
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:3 → 114
    DUF4592; Domain of unknown function (DUF4592)

  6. NM_020722.2 → NP_065773.1  capping protein-inhibiting regulator of actin dynamics isoform 1

    See identical proteins and their annotated locations for NP_065773.1

    Status: VALIDATED

    Source sequence(s)
    AC022267, AC068620
    Consensus CDS
    CCDS43230.1
    UniProtKB/Swiss-Prot
    Q6ZU35, Q9NTE2, Q9NTP8, Q9ULK9
    UniProtKB/TrEMBL
    B7ZMH1
    Related
    ENSP00000264229.6, ENST00000264229.11
    Conserved Domains (4) summary
    PTZ00121
    Location:219 → 526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:623 → 1060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:934 → 1217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    56049098..56330609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415994.1 → XP_047271950.1  capping protein-inhibiting regulator of actin dynamics isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y6P1

  2. XM_047415995.1 → XP_047271951.1  capping protein-inhibiting regulator of actin dynamics isoform X1

    UniProtKB/TrEMBL
    A0A2R8Y6P1
    Related
    ENSP00000495373.2, ENST00000646253.2

  3. XM_005265752.3 → XP_005265809.1  capping protein-inhibiting regulator of actin dynamics isoform X2

    See identical proteins and their annotated locations for XP_005265809.1

    UniProtKB/Swiss-Prot
    Q6ZU35, Q9NTE2, Q9NTP8, Q9ULK9
    UniProtKB/TrEMBL
    B7ZMH1
    Conserved Domains (4) summary
    PTZ00121
    Location:219 → 526
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:623 → 1060
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:934 → 1217
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:45 → 172
    DUF4592; Domain of unknown function (DUF4592)

  4. XM_017008473.2 → XP_016863962.2  capping protein-inhibiting regulator of actin dynamics isoform X3

    UniProtKB/TrEMBL
    F5H1N7
    Related
    ENSP00000444006.1, ENST00000541073.5

  5. XM_005265756.3 → XP_005265813.1  capping protein-inhibiting regulator of actin dynamics isoform X5

    UniProtKB/TrEMBL
    B7ZMH1
    Conserved Domains (4) summary
    PTZ00121
    Location:129 → 436
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:533 → 970
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:844 → 1127
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:2 → 82
    DUF4592; Domain of unknown function (DUF4592)

  6. XM_005265755.3 → XP_005265812.1  capping protein-inhibiting regulator of actin dynamics isoform X4

    UniProtKB/TrEMBL
    B7ZMH1
    Conserved Domains (4) summary
    PTZ00121
    Location:137 → 444
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:541 → 978
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:852 → 1135
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:13 → 90
    DUF4592; Domain of unknown function (DUF4592)

  7. XM_006714045.3 → XP_006714108.1  capping protein-inhibiting regulator of actin dynamics isoform X6

    UniProtKB/TrEMBL
    B7ZMH1
    Conserved Domains (4) summary
    PTZ00121
    Location:105 → 412
    PTZ00121; MAEBL; Provisional
    PHA03247
    Location:509 → 946
    PHA03247; large tegument protein UL36; Provisional
    PRK10811
    Location:820 → 1103
    rne; ribonuclease E; Reviewed
    pfam15262
    Location:5 → 58
    DUF4592; Domain of unknown function (DUF4592)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    59537287..59818577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350561.1 → XP_054206536.1  capping protein-inhibiting regulator of actin dynamics isoform X1

  2. XM_054350560.1 → XP_054206535.1  capping protein-inhibiting regulator of actin dynamics isoform X1

  3. XM_054350562.1 → XP_054206537.1  capping protein-inhibiting regulator of actin dynamics isoform X2

  4. XM_054350563.1 → XP_054206538.1  capping protein-inhibiting regulator of actin dynamics isoform X3

  5. XM_054350565.1 → XP_054206540.1  capping protein-inhibiting regulator of actin dynamics isoform X5

  6. XM_054350564.1 → XP_054206539.1  capping protein-inhibiting regulator of actin dynamics isoform X4

  7. XM_054350566.1 → XP_054206541.1  capping protein-inhibiting regulator of actin dynamics isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZU35.3 GenPept UniProtKB/Swiss-Prot:Q6ZU35

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