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USP31 ubiquitin specific peptidase 31 [ Homo sapiens (human) ]

Gene ID: 57478, updated on 5-Mar-2024

Summary

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Official Symbol
USP31provided by HGNC
Official Full Name
ubiquitin specific peptidase 31provided by HGNC
Primary source
HGNC:HGNC:20060
See related
Ensembl:ENSG00000103404 MIM:619536; AllianceGenome:HGNC:20060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 7.0), urinary bladder (RPKM 3.7) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See USP31 in Genome Data Viewer
Location:
16p12.2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (23061406..23149452, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (23337392..23425432, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23072727..23160773, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(XVI) chain Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:22871179-22871742 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10575 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:22964872-22965382 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:22988092-22988272 Neighboring gene uncharacterized LOC112268176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23079291-23079792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:23104917-23105463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23183549-23184050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23197073-23197574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23197575-23198074 Neighboring gene Sharpr-MPRA regulatory region 8546 Neighboring gene sodium channel epithelial 1 subunit gamma Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:23291226-23291748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10577 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23312821-23313338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23313339-23313855 Neighboring gene sodium channel epithelial 1 subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23359541-23360042 Neighboring gene Sharpr-MPRA regulatory region 1348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:23391379-23391880

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth. Hou Y, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Jul 28. PMID 34184746
  2. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. Tzimas C, et al. Cell Signal, 2006 Jan. PMID 16214042
  3. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245
  4. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. USP31 serves as a potential biomarker for predicting prognosis and immune responses for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing.
    Title: USP31 serves as a potential biomarker for predicting prognosis and immune responses for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing.
  2. USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth.
    Title: USP31 acetylation at Lys1264 is essential for its activity and cervical cancer cell growth.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1203

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
  
Process Evidence Code Pubs
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 31
Names
deubiquitinating enzyme 31
ubiquitin specific proteinase 31
ubiquitin thioesterase 31
ubiquitin thiolesterase 31
ubiquitin-specific-processing protease 31
NP_001374150.1
NP_065769.3
XP_016878986.1
XP_016878987.1
XP_016878988.1
XP_047290345.1
XP_054169505.1
XP_054169506.1
XP_054169507.1
XP_054169508.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387221.1 → NP_001374150.1  ubiquitin carboxyl-terminal hydrolase 31 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC099482, AC127459
    Conserved Domains (2) summary
    PHA03307
    Location:961 → 1169
    PHA03307; transcriptional regulator ICP4; Provisional
    COG5560
    Location:126 → 726
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

  2. NM_020718.4 → NP_065769.3  ubiquitin carboxyl-terminal hydrolase 31 isoform 1

    See identical proteins and their annotated locations for NP_065769.3

    Status: VALIDATED

    Source sequence(s)
    AC099482, AC127459
    Consensus CDS
    CCDS10607.1
    UniProtKB/Swiss-Prot
    Q6AW97, Q6ZTC0, Q6ZTN2, Q70CQ4, Q9ULL7
    Related
    ENSP00000219689.7, ENST00000219689.12
    Conserved Domains (3) summary
    cd02674
    Location:596 → 763
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:129 → 335
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam10243
    Location:1013 → 1346
    MIP-T3; Microtubule-binding protein MIP-T3

RNA

  1. NR_170599.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC099482, AC127459

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    23061406..23149452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023497.3 → XP_016878986.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

    Conserved Domains (3) summary
    cd02674
    Location:333 → 500
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:14 → 72
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam10243
    Location:750 → 1083
    MIP-T3; Microtubule-binding protein MIP-T3

  2. XM_017023498.3 → XP_016878987.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

    Conserved Domains (3) summary
    cd02674
    Location:333 → 500
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:14 → 72
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam10243
    Location:750 → 1083
    MIP-T3; Microtubule-binding protein MIP-T3

  3. XM_017023499.3 → XP_016878988.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X2

  4. XM_047434389.1 → XP_047290345.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    23337392..23425432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313530.1 → XP_054169505.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

  2. XM_054313531.1 → XP_054169506.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X1

  3. XM_054313532.1 → XP_054169507.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X2

  4. XM_054313533.1 → XP_054169508.1  ubiquitin carboxyl-terminal hydrolase 31 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q70CQ4.2 GenPept UniProtKB/Swiss-Prot:Q70CQ4

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