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Isg20 interferon-stimulated protein [ Mus musculus (house mouse) ]

Gene ID: 57444, updated on 2-Nov-2024

Summary

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Official Symbol
Isg20provided by MGI
Official Full Name
interferon-stimulated proteinprovided by MGI
Primary source
MGI:MGI:1928895
See related
Ensembl:ENSMUSG00000039236 AllianceGenome:MGI:1928895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
20kDa; DnaQL; HEM45; 1600023I01Rik; 2010107M23Rik
Summary
Predicted to enable 3'-5' exonuclease activity and RNA binding activity. Predicted to be involved in several processes, including DNA catabolic process; RNA metabolic process; and negative regulation of viral genome replication. Predicted to be located in cytoplasm and nuclear lumen. Predicted to be active in nucleus. Is expressed in liver lobe. Orthologous to human ISG20 (interferon stimulated exonuclease gene 20). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in genital fat pad adult (RPKM 49.6), testis adult (RPKM 49.3) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Isg20 in Genome Data Viewer
Location:
7 D2; 7 44.84 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (78561136..78570144)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (78913396..78920396)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19256 Neighboring gene predicted gene, 39039 Neighboring gene STARR-positive B cell enhancer ABC_E8179 Neighboring gene apoptosis enhancing nuclease Neighboring gene predicted gene, 31213 Neighboring gene predicted gene, 26633 Neighboring gene aggrecan

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury. Jia M, et al. Mol Ther, 2023 Oct 4. PMID 37452495, Free PMC Article
  2. The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins. Weiss CM, et al. mSphere, 2018 Sep 19. PMID 30232164, Free PMC Article
  3. Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer. Lin Y, et al. Reproduction, 2009 Jun. PMID 19321657
  4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury.
    Title: Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injury.
  2. ISG20 upregulated IFIT1 genes and inhibited translation of the alphavirus genome. Furthermore, IFIT1-sensitive alphavirus replication was increased in Isg20(-/-) mice compared to the replication of wild-type viruses but not in cells ectopically expressing ISG20.
    Title: The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.
  3. Suggest that the recruitment of peripheral CXCR4-expressing ITGA2(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance.
    Title: Prevention of embryo loss in non-obese diabetic mice using adoptive ITGA2(+)ISG20(+) natural killer-cell transfer.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables U1 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U1 snRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables U2 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U2 snRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables U3 snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables U3 snoRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables exoribonuclease II activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA 3'-5' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in Cajal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
interferon-stimulated gene 20 kDa protein
Names
interferon stimulated exonuclease
promyelocytic leukemia nuclear body-associated protein ISG20
NP_001106999.1
NP_001278149.1
NP_001278150.1
NP_065608.2
XP_006541089.1
XP_006541091.1
XP_030098687.1
XP_036009174.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113527.1 → NP_001106999.1  interferon-stimulated gene 20 kDa protein isoform b

    See identical proteins and their annotated locations for NP_001106999.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).
    Source sequence(s)
    AK008139, AW122677
    Consensus CDS
    CCDS21376.1
    UniProtKB/TrEMBL
    Q3UW00, Q4FK39
    Related
    ENSMUSP00000113255.2, ENSMUST00000120331.4
    Conserved Domains (1) summary
    cl10012
    Location:8 → 163
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  2. NM_001291220.1 → NP_001278149.1  interferon-stimulated gene 20 kDa protein isoform a

    See identical proteins and their annotated locations for NP_001278149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC138376, AF217484, BE951148
    Consensus CDS
    CCDS71982.1
    UniProtKB/Swiss-Prot
    Q9CPZ5, Q9JL16
    Related
    ENSMUSP00000112621.2, ENSMUST00000121645.8
    Conserved Domains (1) summary
    cl10012
    Location:8 → 144
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  3. NM_001291221.1 → NP_001278150.1  interferon-stimulated gene 20 kDa protein isoform b

    See identical proteins and their annotated locations for NP_001278150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).
    Source sequence(s)
    AC138376, AK136756, BE951148
    Consensus CDS
    CCDS21376.1
    UniProtKB/TrEMBL
    Q3UW00, Q4FK39
    Related
    ENSMUSP00000112480.2, ENSMUST00000118867.8
    Conserved Domains (1) summary
    cl10012
    Location:8 → 163
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  4. NM_020583.5 → NP_065608.2  interferon-stimulated gene 20 kDa protein isoform b

    See identical proteins and their annotated locations for NP_065608.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 4. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 1, 2, and 3 all encode the same isoform (b).
    Source sequence(s)
    AK008353, AK136756, AW122677, BY087214, W97502
    Consensus CDS
    CCDS21376.1
    UniProtKB/TrEMBL
    Q3UW00, Q4FK39
    Related
    ENSMUSP00000040080.9, ENSMUST00000038142.15
    Conserved Domains (1) summary
    cl10012
    Location:8 → 163
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    78561136..78570144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242827.2 → XP_030098687.1  interferon-stimulated gene 20 kDa protein isoform X1

    UniProtKB/Swiss-Prot
    Q9CPZ5, Q9JL16
    Conserved Domains (1) summary
    cl10012
    Location:8 → 144
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  2. XM_036153281.1 → XP_036009174.1  interferon-stimulated gene 20 kDa protein isoform X2

    UniProtKB/TrEMBL
    A0A0U1RP59
    Conserved Domains (1) summary
    cl10012
    Location:8 → 145
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  3. XM_006541026.2 → XP_006541089.1  interferon-stimulated gene 20 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_006541089.1

    UniProtKB/Swiss-Prot
    Q9CPZ5, Q9JL16
    Conserved Domains (1) summary
    cl10012
    Location:8 → 144
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  4. XM_006541028.5 → XP_006541091.1  interferon-stimulated gene 20 kDa protein isoform X1

    See identical proteins and their annotated locations for XP_006541091.1

    UniProtKB/Swiss-Prot
    Q9CPZ5, Q9JL16
    Conserved Domains (1) summary
    cl10012
    Location:8 → 144
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL16.1 GenPept UniProtKB/Swiss-Prot:Q9JL16

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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