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Marchf7 membrane associated ring-CH-type finger 7 [ Mus musculus (house mouse) ]

Gene ID: 57438, updated on 3-Nov-2024

Summary

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Official Symbol
Marchf7provided by MGI
Official Full Name
membrane associated ring-CH-type finger 7provided by MGI
Primary source
MGI:MGI:1931053
See related
Ensembl:ENSMUSG00000026977 AllianceGenome:MGI:1931053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Axo; Axot; March7; Gtrgeo17
Summary
Enables enzyme binding activity and ubiquitin binding activity. Involved in protein autoubiquitination. Acts upstream of or within negative regulation of T cell proliferation and regulation of tolerance induction. Located in cytosol; nucleus; and plasma membrane. Is expressed in brain; early conceptus; and telencephalon. Orthologous to human MARCHF7 (membrane associated ring-CH-type finger 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.5), CNS E18 (RPKM 13.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Marchf7 in Genome Data Viewer
Location:
2 C1.1; 2 34.46 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (60040086..60079555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (60209936..60248385)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene STARR-positive B cell enhancer ABC_E5921 Neighboring gene STARR-positive B cell enhancer ABC_E4454 Neighboring gene predicted gene 13570 Neighboring gene STARR-seq mESC enhancer starr_04605 Neighboring gene lactate dehydrogenase A, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5922 Neighboring gene STARR-seq mESC enhancer starr_04606 Neighboring gene STARR-seq mESC enhancer starr_04607 Neighboring gene STARR-seq mESC enhancer starr_04608 Neighboring gene ribosomal protein L10A, pseudogene 4 Neighboring gene CD302 antigen Neighboring gene lymphocyte antigen 75 Neighboring gene predicted gene 13571

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Leukaemia inhibitory factor (LIF) is functionally linked to axotrophin and both LIF and axotrophin are linked to regulatory immune tolerance. Metcalfe SM, et al. FEBS Lett, 2005 Jan 31. PMID 15670816
  2. A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor. Thompson LH, et al. Cell Cycle, 2010 Oct 15. PMID 20962578, Free PMC Article
  3. Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance. Muthukumarana PA, et al. Int Immunopharmacol, 2006 Dec 20. PMID 17161353
  4. GAS5 protects against nonalcoholic fatty liver disease via miR-28a-5p/MARCH7/NLRP3 axis-mediated pyroptosis. Chen T, et al. Cell Death Differ, 2023 Jul. PMID 37337032, Free PMC Article
  5. A wild derived quantitative trait locus on mouse chromosome 2 prevents obesity. Mollah MB, et al. BMC Genet, 2010 Sep 23. PMID 20860848, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data demonstrate that T cells retain responsiveness to a LIF/Nanog axis and that this axis is linked to MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.
    Title: A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor.
  2. Data suggest that thymic Foxp3+T cell development is influenced by axotrophin.
    Title: Evidence for functional inter-relationships between FOXP3, leukaemia inhibitory factor, and axotrophin/MARCH-7 in transplantation tolerance.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MDM2/MDM4 family protein binding IEA
Inferred from Electronic Annotation
more info
  
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein autoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of tolerance induction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF7
Names
E3 ubiquitin-protein ligase MARCH7
MARCH-VII
RING-type E3 ubiquitin transferase MARCH7
RING-type E3 ubiquitin transferase MARCHF7
axotrophin
gene trap ROSA b-geo 17
membrane-associated RING finger protein 7
membrane-associated RING-CH protein VII
membrane-associated ring finger (C3HC4) 7
NP_001405416.1
NP_001405417.1
NP_001405418.1
NP_001405419.1
NP_001405420.1
NP_001405421.1
NP_001405422.1
NP_065600.1
XP_036018314.1
XP_036018315.1
XP_036018320.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418487.1 → NP_001405416.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL935326

  2. NM_001418488.1 → NP_001405417.1  E3 ubiquitin-protein ligase MARCHF7 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL935326

  3. NM_001418489.1 → NP_001405418.1  E3 ubiquitin-protein ligase MARCHF7 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL935326
    UniProtKB/Swiss-Prot
    Q9WV66
    Related
    ENSMUSP00000099808.2, ENSMUST00000102747.8

  4. NM_001418490.1 → NP_001405419.1  E3 ubiquitin-protein ligase MARCHF7 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL935326

  5. NM_001418491.1 → NP_001405420.1  E3 ubiquitin-protein ligase MARCHF7 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL935326

  6. NM_001418492.1 → NP_001405421.1  E3 ubiquitin-protein ligase MARCHF7 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL935326

  7. NM_001418493.1 → NP_001405422.1  E3 ubiquitin-protein ligase MARCHF7 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL935326

  8. NM_020575.3 → NP_065600.1  E3 ubiquitin-protein ligase MARCHF7 isoform b

    See identical proteins and their annotated locations for NP_065600.1

    Status: VALIDATED

    Source sequence(s)
    AL935326
    Consensus CDS
    CCDS16057.1
    UniProtKB/Swiss-Prot
    Q9WV66
    Related
    ENSMUSP00000099809.5, ENSMUST00000102748.11
    Conserved Domains (2) summary
    cd00162
    Location:554 → 609
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:554 → 612
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. NR_184755.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935326

  2. NR_184756.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935326

  3. NR_184757.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935326

  4. NR_184758.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935326

  5. NR_184759.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935326

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    60040086..60079555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162421.1 → XP_036018314.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    Conserved Domains (2) summary
    cd00162
    Location:554 → 609
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:554 → 612
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_036162427.1 → XP_036018320.1  E3 ubiquitin-protein ligase MARCHF7 isoform X5

    Conserved Domains (2) summary
    cd00162
    Location:263 → 318
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:263 → 321
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_036162422.1 → XP_036018315.1  E3 ubiquitin-protein ligase MARCHF7 isoform X1

    Conserved Domains (2) summary
    cd00162
    Location:554 → 609
    RING_Ubox; RING-CH finger (C4HC3-type) [structural motif]
    cl17238
    Location:554 → 612
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RNA

  1. XR_004940676.1 RNA Sequence

  2. XR_004940674.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV66.1 GenPept UniProtKB/Swiss-Prot:Q9WV66

Gene LinkOut

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