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clos closca [ Drosophila melanogaster (fruit fly) ]

Gene ID: 5740204, updated on 2-Nov-2024

Summary

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Official Symbol
closprovided by FlyBase
Official Full Name
closcaprovided by FlyBase
Primary source
FLYBASE:FBgn0261016
Locus tag
Dmel_CG42600
See related
AllianceGenome:FB:FBgn0261016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12927; CG12928; CG1863; CG33479; CG34364; CG42600; Dmel\CG42600
Old locus tag
CG12927; CG1863; CG33479; Dmel_CG12927; Dmel_CG12928; Dmel_CG1863; Dmel_CG33479; Dmel_CG34364
Summary
Involved in axis specification; torso signaling pathway; and vitelline membrane formation involved in chorion-containing eggshell formation. Located in extracellular region. Is expressed in oocyte and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 98; ectodermal dysplasia 14; and tooth agenesis. Orthologous to human TSPEAR (thrombospondin type laminin G domain and EAR repeats). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See clos in Genome Data Viewer
Location:
45F5-45F6; 2-61 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9587953..9599732, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5475458..5487237, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene 5' nucleotidase C Neighboring gene SET and MYND domain containing, class 4, member 1 Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L31 Neighboring gene uncharacterized protein Neighboring gene Microtubule-associated protein 60 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins in Drosophila. Mineo A, et al. Genetics, 2017 Apr. PMID 28179368, Free PMC Article
  2. closca, a new gene required for both Torso RTK activation and vitelline membrane integrity. Germline proteins contribute to Drosophila eggshell composition. Ventura G, et al. Dev Biol, 2010 Aug 1. PMID 20457146
  3. Conserved and divergent elements in Torso RTK activation in Drosophila development. Grillo M, et al. Sci Rep, 2012. PMID 23094137, Free PMC Article
  4. Organization and regulation of sex-specific thioredoxin encoding genes in the genus Drosophila. Svensson MJ, et al. Dev Genes Evol, 2007 Sep. PMID 17701050
  5. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in terminal region determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in torso signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vitelline membrane formation involved in chorion-containing eggshell formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
closca
Names
CG42600-PD
clos-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9587953..9599732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001103776.3 → NP_001097246.3  closca [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097246.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DQW8
    Conserved Domains (1) summary
    pfam03736
    Location:263 → 315
    EPTP; EPTP domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8DQW8 A8DQW8

Gene LinkOut

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