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eif2a eukaryotic translation initiation factor 2A [ Danio rerio (zebrafish) ]

Gene ID: 573991, updated on 2-Nov-2024

Summary

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Official Symbol
eif2aprovided by ZNC
Official Full Name
eukaryotic translation initiation factor 2Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050626-52
See related
Ensembl:ENSDARG00000101061 AllianceGenome:ZFIN:ZDB-GENE-050626-52
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7145971; zgc:110460
Summary
Predicted to enable nucleic acid binding activity and ribosome binding activity. Predicted to act upstream of or within regulation of translation and translational initiation. Predicted to be part of cytosolic small ribosomal subunit. Orthologous to human EIF2A (eukaryotic translation initiation factor 2A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See eif2a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (3552641..3571568, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (3455556..3474483, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100538302 Neighboring gene DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) Neighboring gene stress-associated endoplasmic reticulum protein 1 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Heat resilience in embryonic zebrafish revealed using an in vivo stress granule reporter. Wang R, et al. J Cell Sci, 2019 Oct 18. PMID 31558681, Free PMC Article
  2. A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis. Liu ZY, et al. Gene, 2013 Sep 15. PMID 23742890
  3. Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with activation of unfolded protein response in male zebrafish. Qin J, et al. Environ Pollut, 2020 Aug. PMID 32283406
  4. Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Mi X, et al. Biochim Biophys Acta Mol Basis Dis, 2020 Oct 1. PMID 32446740
  5. Gene Characterization of Nocturnin Paralogues in Goldfish: Full Coding Sequences, Structure, Phylogeny and Tissue Expression. Madera D, et al. Int J Mol Sci, 2023 Dec 19. PMID 38203224, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both DrPKZ-A and DrPKZ-B isoforms functionally interact with eIF2alpha and inhibit protein synthesis in Danio rerio.
    Title: A truncated Danio rerio PKZ isoform functionally interacts with eIF2α and inhibits protein synthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 2A
Names
eIF-2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025170.2 → NP_001020341.1  eukaryotic translation initiation factor 2A

    See identical proteins and their annotated locations for NP_001020341.1

    Status: PROVISIONAL

    Source sequence(s)
    BC096815
    UniProtKB/Swiss-Prot
    Q4QRJ7
    UniProtKB/TrEMBL
    B2GSC5
    Related
    ENSDARP00000132954.1, ENSDART00000168842.2
    Conserved Domains (2) summary
    pfam08662
    Location:215 → 410
    eIF2A; Eukaryotic translation initiation factor eIF2A
    sd00039
    Location:275 → 320
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    3552641..3571568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QRJ7.1 GenPept UniProtKB/Swiss-Prot:Q4QRJ7

Gene LinkOut

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