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As3mt arsenite methyltransferase [ Mus musculus (house mouse) ]

Gene ID: 57344, updated on 18-Sep-2024

Summary

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Official Symbol
As3mtprovided by MGI
Official Full Name
arsenite methyltransferaseprovided by MGI
Primary source
MGI:MGI:1929882
See related
Ensembl:ENSMUSG00000003559 AllianceGenome:MGI:1929882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyt19; 2310045H08Rik
Summary
Predicted to enable arsenite methyltransferase activity and methylarsonite methyltransferase activity. Predicted to be involved in arsonoacetate metabolic process; methylation; and toxin metabolic process. Predicted to act upstream of or within response to arsenic-containing substance. Located in mitochondrion. Orthologous to human AS3MT (arsenite methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 19.2), heart adult (RPKM 12.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See As3mt in Genome Data Viewer
Location:
19 C3; 19 38.97 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46695124..46729538)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46707157..46741099)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41857 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene BLOC-1 related complex subunit 7 Neighboring gene STARR-positive B cell enhancer ABC_E8753 Neighboring gene cyclin M2 Neighboring gene STARR-seq mESC enhancer starr_46325 Neighboring gene STARR-seq mESC enhancer starr_46328 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46962419-46962620 Neighboring gene 5'-nucleotidase, cytosolic II Neighboring gene DBF4 homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The gut microbiome is required for full protection against acute arsenic toxicity in mouse models. Coryell M, et al. Nat Commun, 2018 Dec 21. PMID 30575732, Free PMC Article
  2. Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure. Douillet C, et al. Arch Toxicol, 2017 Jul. PMID 27847981, Free PMC Article
  3. Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure. Huang MC, et al. Arch Toxicol, 2017 Jan. PMID 26883664, Free PMC Article
  4. Mouse arsenic (+3 oxidation state) methyltransferase genotype affects metabolism and tissue dosimetry of arsenicals after arsenite administration in drinking water. Chen B, et al. Toxicol Sci, 2011 Dec. PMID 21934131
  5. Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice. Yokohira M, et al. Toxicol Sci, 2011 Jun. PMID 21385732

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of As3mt and Mth1 in the genotoxic and carcinogenic effects induced by long-term exposures to arsenic in MEF cells.
    Title: Role of As3mt and Mth1 in the genotoxic and carcinogenic effects induced by long-term exposures to arsenic in MEF cells.
  2. As3mt role in obesity and insulin resistance
    Title: Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure.
  3. Data, including date from studies in knockout mice, suggest that As3mt is involved in energy metabolism in a sex-specific manner, independent of inorganic arsenic poisoning; thus, As3mt may be involved in cellular processes beyond methylation of inorganic arsenic.
    Title: Metabolomic profiles of arsenic (+3 oxidation state) methyltransferase knockout mice: effect of sex and arsenic exposure.
  4. Oxidative damage and Ogg1 deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism.
    Title: Reduced cellular DNA repair capacity after environmentally relevant arsenic exposure. Influence of Ogg1 deficiency.
  5. Simple hyperplasia of the bladder epithelium was detected in all As3mt KO mice treated with sodium arsenite.
    Title: Effect of sodium arsenite dose administered in the drinking water on the urinary bladder epithelium of female arsenic (+3 oxidation state) methyltransferase knockout mice.
  6. Rat, mouse and human are efficient methylators of inorganic arsenic. Findings suggest a role for AS3MT in the methylation of inorganic arsenic.
    Title: Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arsenite methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arsenite methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables arsenite methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in arsonoacetate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arsonoacetate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in arsonoacetate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in toxin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in toxin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
arsenite methyltransferase
Names
S-adenosyl-L-methionine:arsenic(III) methyltransferase
S-adenosylmethionine:arsenic (III) methyltransferase
arsenic (+3 oxidation state) methyltransferase
methylarsonite methyltransferase
methyltransferase Cyt19
NP_065602.2
XP_006527298.1
XP_011245604.1
XP_030106865.1
XP_036017540.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020577.3 → NP_065602.2  arsenite methyltransferase

    See identical proteins and their annotated locations for NP_065602.2

    Status: VALIDATED

    Source sequence(s)
    AC161865
    Consensus CDS
    CCDS50458.1
    UniProtKB/Swiss-Prot
    A6H5W4, E9QLU6, Q91WU5, Q9QZT1
    Related
    ENSMUSP00000003655.8, ENSMUST00000003655.9
    Conserved Domains (1) summary
    pfam13847
    Location:71 → 183
    Methyltransf_31; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46695124..46729538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527235.3 → XP_006527298.1  arsenite methyltransferase isoform X1

    Conserved Domains (1) summary
    PRK11873
    Location:61 → 266
    arsM; arsenite methyltransferase

  2. XM_030251005.2 → XP_030106865.1  arsenite methyltransferase isoform X2

    Conserved Domains (1) summary
    PRK11873
    Location:9 → 96
    arsM; arsenite methyltransferase

  3. XM_011247302.4 → XP_011245604.1  arsenite methyltransferase isoform X2

    Conserved Domains (1) summary
    PRK11873
    Location:9 → 96
    arsM; arsenite methyltransferase

  4. XM_036161647.1 → XP_036017540.1  arsenite methyltransferase isoform X2

    Conserved Domains (1) summary
    PRK11873
    Location:9 → 96
    arsM; arsenite methyltransferase

RNA

  1. XR_003952795.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WU5.2 GenPept UniProtKB/Swiss-Prot:Q91WU5

Gene LinkOut

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