khsrp KH-type splicing regulatory protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: khsrpprovided by ZNC
Official Full Name: KH-type splicing regulatory proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4357
See related: Ensembl:ENSDARG00000026489 AllianceGenome:ZFIN:ZDB-GENE-030131-4357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu1000; sb:eu1001; wu:fb25b12; wu:fc10e10; wu:fc94c12; zgc:163038
Summary: Enables mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in cytoplasm and nucleus. Orthologous to human KHSRP (KH-type splicing regulatory protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (54960186..54972236, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (54282538..54294585, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

khsrp (e-PCR)
- UniSTS:205589

fb25b12.y1 (e-PCR)
- UniSTS:190351

fc94c12.x1 (e-PCR)
- UniSTS:204013

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR AU-rich region binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: far upstream element-binding protein 2

Names: FUSE binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089428.2 → NP_001082897.2 far upstream element-binding protein 2

Status: VALIDATED

Source sequence(s)

AL929150

UniProtKB/TrEMBL

A4QP88

Related

ENSDARP00000032748.7, ENSDART00000038330.9

Conserved Domains (1) summary

pfam00013
Location:108 → 172

KH_1; KH domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

54960186..54972236 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160179.5 → XP_005160236.1 far upstream element-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A8M2B6Z8, A4QP88

Conserved Domains (1) summary

cd00105
Location:81 → 143

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...