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CHLRE_02g085257v5 uncharacterized protein [ Chlamydomonas reinhardtii ]

Gene ID: 5727376, updated on 7-Dec-2023

Summary

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Gene symbol
CHLRE_02g085257v5
Gene description
uncharacterized protein
Primary source
Phytozome:Cre02.g085257
Locus tag
CHLRE_02g085257v5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Chlamydomonas reinhardtii (strain: CC-503 cw92 mt+)
Lineage
Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae; CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas
Old locus tag
CHLREDRAFT_182032
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Genomic context

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See CHLRE_02g085257v5 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
20
Sequence:
Chromosome: 2; NC_057005.1 (1623925..1631068)

Chromosome 2 - NC_057005.1Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_057005.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function. Kaufmann JCD, et al. J Biol Chem, 2017 Aug 25. PMID 28659342, Free PMC Article
  2. Channelrhodopsin unchained: structure and mechanism of a light-gated cation channel. Lórenz-Fonfría VA, et al. Biochim Biophys Acta, 2014 May. PMID 24212055
  3. Towards an understanding of channelrhodopsin function: simulations lead to novel insights of the channel mechanism. Watanabe HC, et al. J Mol Biol, 2013 May 27. PMID 23376098
  4. In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle. Eisenhauer K, et al. J Biol Chem, 2012 Feb 24. PMID 22219197, Free PMC Article
  5. The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant. Bruun S, et al. FEBS Lett, 2011 Dec 15. PMID 22094167

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the central gate residue Glu-90 in ChR2/COP4 (i) undergoes a hydrogen bond change in D->K transition and (ii) deprotonates in K->M transition; negative charge in open state is decisive for cation selectivity (Na+, K+, vs. Ca2+).
    Title: Proton transfer reactions in the red light-activatable channelrhodopsin variant ReaChR and their relevance for its function.
  2. channelrhodopsin-2 C128T has been studied by resonance Raman (RR) spectroscopy [ChR2]
    Title: The chromophore structure of the long-lived intermediate of the C128T channelrhodopsin-2 variant.
  3. Proton transfer reactions that are associated with channel gating are mediated by glutamate 253 and aspartic acid 156. (Review)
    Title: Channelrhodopsin unchained: structure and mechanism of a light-gated cation channel.
  4. Structural characteristics of channelrhodopsin are discussed that are highly involved in molecular dynamics, ion channel gating, and ion transport.
    Title: Towards an understanding of channelrhodopsin function: simulations lead to novel insights of the channel mechanism.
  5. The deprotonation of Glu-90 during the photocycle is elucidated by time-resolved spectroscopy, which seems to be part of the opening mechanism of the conductive pore.
    Title: In channelrhodopsin-2 Glu-90 is crucial for ion selectivity and is deprotonated during the photocycle.
  6. Stages of the photoreaction preceding (P(1) state) and succeeding (P(4)) the conductive state of the channel (P(3)) are associated with large conformational changes of the protein backbone. [Channelrhodopsin-2]
    Title: Conformational changes of channelrhodopsin-2.
  7. Point mutation of ChR2 that replaces glutamic acid residue 97 by alanine causes the photocurrent to become reduced in amplitude without influencing its reversal potential, kinetic profile or sensitivity to light power density. [channelrhodopsin-2] [CHR2]
    Title: Photocurrent attenuation by a single polar-to-nonpolar point mutation of channelrhodopsin-2.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_057005.1 Reference assembly

    Range
    1623925..1631068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001701673.2 → XP_001701725.1  uncharacterized protein CHLRE_02g085257v5 [Chlamydomonas reinhardtii]

    See identical proteins and their annotated locations for XP_001701725.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q8RUT8
    Conserved Domains (1) summary
    cd15241
    Location:50 → 268
    7tm_ChRs; channelrhodopsins, member of the seven-transmembrane GPCR superfamily
Nucleotide Protein
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