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ibtk inhibitor of Bruton agammaglobulinemia tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 572463, updated on 2-Nov-2024

Summary

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Official Symbol
ibtkprovided by ZNC
Official Full Name
inhibitor of Bruton agammaglobulinemia tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6246
See related
Ensembl:ENSDARG00000074424 AllianceGenome:ZFIN:ZDB-GENE-030131-6246
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi40c08; wu:fi40c08
Summary
Predicted to enable protein kinase binding activity and protein tyrosine kinase inhibitor activity. Predicted to be involved in release of sequestered calcium ion into cytosol. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in telencephalon. Orthologous to human IBTK (inhibitor of Bruton tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ibtk in Genome Data Viewer
Location:
chromosome: 16
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (4839073..4896066)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (5009789..5067059)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3D Neighboring gene trophoblast glycoprotein Neighboring gene terminal nucleotidyltransferase 5Aa Neighboring gene branched chain keto acid dehydrogenase E1 subunit beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
inhibitor of Bruton tyrosine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    4839073..4896066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157859.5 → XP_005157916.1  inhibitor of Bruton tyrosine kinase

    UniProtKB/TrEMBL
    A0A286YAJ6, A0A8M2B4T9
    Related
    ENSDARP00000143997.2, ENSDART00000179363.2
    Conserved Domains (7) summary
    smart00225
    Location:774 → 869
    BTB; Broad-Complex, Tramtrack and Bric a brac
    cd00204
    Location:24 → 136
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14821
    Location:876 → 932
    SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
    pfam00415
    Location:196 → 245
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam00651
    Location:766 → 869
    BTB; BTB/POZ domain
    pfam12796
    Location:24 → 117
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:51 → 83
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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