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PSPH phosphoserine phosphatase [ Homo sapiens (human) ]

Gene ID: 5723, updated on 11-Apr-2024

Summary

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Official Symbol
PSPHprovided by HGNC
Official Full Name
phosphoserine phosphataseprovided by HGNC
Primary source
HGNC:HGNC:9577
See related
Ensembl:ENSG00000146733 MIM:172480; AllianceGenome:HGNC:9577
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSP; PSPHD
Summary
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 3.8), thyroid (RPKM 3.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (56011064..56051444, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (56170861..56211278, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (56078757..56119137, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26043 Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18192 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:56032587-56033320 Neighboring gene nipsnap homolog 2 Neighboring gene MPRA-validated peak6528 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26049 Neighboring gene small nucleolar RNA, H/ACA box 22B Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene small nucleolar RNA, H/ACA box 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase. Haufroid M, et al. Acta Crystallogr D Struct Biol, 2019 Jun 1. PMID 31205021
  2. PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways. Liao L, et al. Int J Biol Sci, 2019. PMID 30662358, Free PMC Article
  3. Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer. Sato K, et al. Anticancer Res, 2017 May. PMID 28476802
  4. Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan. Vincent JB, et al. Clin Genet, 2015 Mar. PMID 25080166
  5. Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. Kim HY, et al. J Biol Chem, 2002 Nov 29. PMID 12213811

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
    Title: PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
  2. a specific interaction between PSPH and IRS1 and the dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells, was identified.
    Title: Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.
  3. The results suggest that PSPH may act as a putative oncogene and a potential therapeutic target in NSCLC.
    Title: PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.
  4. three new high-resolution crystal structures of hPSP (1.5-2.0 A) in complexes with phosphoserine and with serine, which are the substrate and the product of the reaction, respectively, and in complex with a noncleavable substrate analogue (homocysteic acid) are presented.
    Title: Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.
  5. PSPH expression is a novel biomarker for poor prognosis and could play an important role in tumor progression of colorectal cancer.
    Title: Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer.
  6. We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo
    Title: cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
  7. study of an intellectual disability family from Pakistan; identified a variant in PSPH: chr7:56088803C>T, NM_004577.3 c.103G>A; p.Ala35Thr (hg19) which segregated in homozygous form with the phenotype in both branches of the family
    Title: Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan.
  8. phosphoserine phosphatase deficiency is associated with Neu-Laxova syndrome.
    Title: Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.
  9. status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation
    Title: L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis.
  10. human phosphoserine phosphatase structure now shows a sevenfold coordinated Ca(2+) ion in the active site that might explain the inhibitory effect of Ca(2+) on the enzyme
    Title: How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Deficiency of phosphoserine phosphatase
MedGen: C1291463 OMIM: 614023 GeneReviews: Serine Deficiency Disorders
Compare labs

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-phosphoserine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-phosphoserine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-phosphoserine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-serine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-serine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
  
involved_in response to testosterone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
phosphoserine phosphatase
Names
L-3-phosphoserine phosphatase
O-phosphoserine phosphohydrolase
PSPase
NP_001357432.1
NP_001357433.1
NP_001357434.1
NP_001357435.1
NP_001357436.1
NP_001357437.1
NP_001357438.1
NP_001357439.1
NP_001357440.1
NP_001357441.1
NP_001357442.1
NP_001357443.1
NP_001357444.1
NP_001357445.1
NP_001357446.1
NP_001357447.1
NP_001357448.1
NP_001357449.1
NP_001357450.1
NP_001357451.1
NP_004568.2
XP_006715824.1
XP_016867956.1
XP_016867957.1
XP_016867958.1
XP_047276600.1
XP_047276601.1
XP_047276602.1
XP_047276603.1
XP_047276604.1
XP_047276605.1
XP_047276606.1
XP_047276607.1
XP_047276608.1
XP_047276609.1
XP_047276610.1
XP_054214668.1
XP_054214669.1
XP_054214670.1
XP_054214671.1
XP_054214672.1
XP_054214673.1
XP_054214674.1
XP_054214675.1
XP_054214676.1
XP_054214677.1
XP_054214678.1
XP_054214679.1
XP_054214680.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011473.1 RefSeqGene

    Range
    5132..45512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370503.1 → NP_001357432.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Related
    ENSP00000378854.3, ENST00000395471.7
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  2. NM_001370504.1 → NP_001357433.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  3. NM_001370505.1 → NP_001357434.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  4. NM_001370506.1 → NP_001357435.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  5. NM_001370507.1 → NP_001357436.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  6. NM_001370508.1 → NP_001357437.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  7. NM_001370509.1 → NP_001357438.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Related
    ENSP00000401639.2, ENST00000437355.6
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  8. NM_001370510.1 → NP_001357439.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  9. NM_001370511.1 → NP_001357440.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  10. NM_001370512.1 → NP_001357441.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Related
    ENSP00000398653.1, ENST00000421626.5
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  11. NM_001370513.1 → NP_001357442.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  12. NM_001370514.1 → NP_001357443.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  13. NM_001370515.1 → NP_001357444.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  14. NM_001370516.1 → NP_001357445.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  15. NM_001370517.1 → NP_001357446.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  16. NM_001370518.1 → NP_001357447.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  17. NM_001370519.1 → NP_001357448.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  18. NM_001370520.1 → NP_001357449.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  19. NM_001370521.1 → NP_001357450.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  20. NM_001370522.1 → NP_001357451.1  phosphoserine phosphatase

    Status: REVIEWED

    Source sequence(s)
    AC092579
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  21. NM_004577.4 → NP_004568.2  phosphoserine phosphatase

    See identical proteins and their annotated locations for NP_004568.2

    Status: REVIEWED

    Source sequence(s)
    AW574794, BC052958, BC063614, Y10275
    Consensus CDS
    CCDS5522.1
    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Related
    ENSP00000275605.3, ENST00000275605.8
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    56011064..56051444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420650.1 → XP_047276606.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  2. XM_047420652.1 → XP_047276608.1  phosphoserine phosphatase isoform X2

  3. XM_017012469.3 → XP_016867958.1  phosphoserine phosphatase isoform X2

    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (2) summary
    pfam00702
    Location:47 → 141
    Hydrolase; haloacid dehalogenase-like hydrolase
    cl21460
    Location:10 → 179
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  4. XM_047420649.1 → XP_047276605.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  5. XM_006715761.3 → XP_006715824.1  phosphoserine phosphatase isoform X2

    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (2) summary
    pfam00702
    Location:47 → 141
    Hydrolase; haloacid dehalogenase-like hydrolase
    cl21460
    Location:10 → 179
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  6. XM_017012468.3 → XP_016867957.1  phosphoserine phosphatase isoform X2

    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (2) summary
    pfam00702
    Location:47 → 141
    Hydrolase; haloacid dehalogenase-like hydrolase
    cl21460
    Location:10 → 179
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  7. XM_047420644.1 → XP_047276600.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  8. XM_047420645.1 → XP_047276601.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  9. XM_047420647.1 → XP_047276603.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  10. XM_047420648.1 → XP_047276604.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  11. XM_047420646.1 → XP_047276602.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  12. XM_047420653.1 → XP_047276609.1  phosphoserine phosphatase isoform X2

  13. XM_017012467.3 → XP_016867956.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5
    UniProtKB/TrEMBL
    Q53EY1
    Conserved Domains (1) summary
    cd04309
    Location:15 → 216
    HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

  14. XM_047420651.1 → XP_047276607.1  phosphoserine phosphatase isoform X2

  15. XM_047420654.1 → XP_047276610.1  phosphoserine phosphatase isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    56170861..56211278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358699.1 → XP_054214674.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  2. XM_054358703.1 → XP_054214678.1  phosphoserine phosphatase isoform X2

  3. XM_054358704.1 → XP_054214679.1  phosphoserine phosphatase isoform X2

  4. XM_054358698.1 → XP_054214673.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  5. XM_054358700.1 → XP_054214675.1  phosphoserine phosphatase isoform X2

  6. XM_054358701.1 → XP_054214676.1  phosphoserine phosphatase isoform X2

  7. XM_054358693.1 → XP_054214668.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  8. XM_054358695.1 → XP_054214670.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  9. XM_054358696.1 → XP_054214671.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  10. XM_054358694.1 → XP_054214669.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  11. XM_054358697.1 → XP_054214672.1  phosphoserine phosphatase isoform X1

    UniProtKB/Swiss-Prot
    B2RCR5, P78330, Q7Z3S5

  12. XM_054358702.1 → XP_054214677.1  phosphoserine phosphatase isoform X2

  13. XM_054358705.1 → XP_054214680.1  phosphoserine phosphatase isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P78330.2 GenPept UniProtKB/Swiss-Prot:P78330

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