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GFOD3P Gfo/Idh/MocA-like oxidoreductase domain containing 3, pseudogene [ Homo sapiens (human) ]

Gene ID: 57212, updated on 5-Mar-2024

Summary

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Official Symbol
GFOD3Pprovided by HGNC
Official Full Name
Gfo/Idh/MocA-like oxidoreductase domain containing 3, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:29052
See related
Ensembl:ENSG00000293478 AllianceGenome:HGNC:29052
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDAM; KIAA0495; TP73-AS1
Expression
Ubiquitous expression in testis (RPKM 8.0), ovary (RPKM 7.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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See GFOD3P in Genome Data Viewer
Location:
1p36.32
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (3735984..3747373, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (3247585..3258974, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3652548..3663937, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TP73 antisense RNA 3 Neighboring gene tumor protein p73 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 63 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 64 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3596796-3596963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3597253-3597988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3600129-3600889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3605575-3606096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3606097-3606618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3623899-3624726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3624727-3625555 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3631158-3631397 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3634425-3634984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3634985-3635544 Neighboring gene TP73 antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3636665-3637223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3637224-3637783 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3637784-3638342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 65 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3650019-3650807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3661686-3662521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3662522-3663358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3678785-3679286 Neighboring gene coiled-coil domain containing 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3679287-3679786 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3687696-3688374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3689661-3690176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3690177-3690692 Neighboring gene MPRA functional variant 1:3691528:A:G red blood cell enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3691725-3692240 Neighboring gene small integral membrane protein 1 (Vel blood group)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel tumor suppressor encoded by a 1p36.3 lncRNA functions as a phosphoinositide-binding protein repressing AKT phosphorylation/activation and promoting autophagy. Li L, et al. Cell Death Differ, 2023 May. PMID 36813924,
  2. Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis. Fan J, et al. Genes Genomics, 2022 Jul. PMID 34480734
  3. Long non-coding RNA TP73-AS1 promotes pancreatic cancer growth and metastasis through miRNA-128-3p/GOLM1 axis. Wang B, et al. World J Gastroenterol, 2021 May 7. PMID 34007135, Free PMC Article
  4. LncRNA TP73-AS1 enhances the malignant properties of pancreatic ductal adenocarcinoma by increasing MMP14 expression through miRNA -200a sponging. Miao H, et al. J Cell Mol Med, 2021 Apr. PMID 33683827, Free PMC Article
  5. Long non-coding RNA TP73-AS1 is a potential immune related prognostic biomarker for glioma. Zhang B, et al. Aging (Albany NY), 2021 Feb 11. PMID 33589576, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of long noncoding RNA TP73-AS1 expression confers resistance to temozolomide in human glioblastoma cells.
    Title: Downregulation of long noncoding RNA TP73-AS1 expression confers resistance to temozolomide in human glioblastoma cells.
  2. LncRNA TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539-5p sponging.
    Title: LncRNA TP73-AS1 enhances the malignant properties of colorectal cancer by increasing SPP-1 expression through miRNA-539-5p sponging.
  3. Long non-coding RNA tumor protein 73 antisense RNA 1 influences an interaction between lysine demethylase 5A and promoter of tumor protein 73 to enhance the malignancy of colorectal cancer.
    Title: Long non-coding RNA tumor protein 73 antisense RNA 1 influences an interaction between lysine demethylase 5A and promoter of tumor protein 73 to enhance the malignancy of colorectal cancer.
  4. Silencing of TP73-AS1 impairs prostate cancer cell proliferation and induces apoptosis via regulation of TP73.
    Title: Silencing of TP73-AS1 impairs prostate cancer cell proliferation and induces apoptosis via regulation of TP73.
  5. Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis.
    Title: Association of a novel antisense lncRNA TP73-AS1 polymorphisms and expression with colorectal cancer susceptibility and prognosis.
  6. LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
    Title: LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
  7. LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.
    Title: LncRNA TP73-AS1 promotes oxidized low-density lipoprotein-induced apoptosis of endothelial cells in atherosclerosis by targeting the miR-654-3p/AKT3 axis.
  8. lncRNA TP73-AS1 Regulates miR-21/PTEN Axis to Affect Cell Proliferation in Acute Myeloid Leukemia.
    Title: lncRNA TP73-AS1 Regulates miR-21/PTEN Axis to Affect Cell Proliferation in Acute Myeloid Leukemia.
  9. LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-beta1 signaling.
    Title: LncRNA TP73-AS1/miR-539/MMP-8 axis modulates M2 macrophage polarization in hepatocellular carcinoma via TGF-β1 signaling.
  10. LncRNA TP73-AS1 enhances the malignant properties of pancreatic ductal adenocarcinoma by increasing MMP14 expression through miRNA -200a sponging.
    Title: LncRNA TP73-AS1 enhances the malignant properties of pancreatic ductal adenocarcinoma by increasing MMP14 expression through miRNA -200a sponging.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • TP73 antisense RNA 1 (non-protein coding)
  • p53-dependent apoptosis modulator

Clone Names

  • KIAA0495, MGC138189

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_033708.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal segment, compared to variant 1.
    Source sequence(s)
    AL136528, BC035073, BC089039
    Related
    ENST00000647831.1

  2. NR_033709.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal segment, compared to variant 1.
    Source sequence(s)
    AL136528, BC089039

  3. NR_033710.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment, compared to variant 1.
    Source sequence(s)
    AL133648, AL136528, BC089039

  4. NR_033711.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AB007964, AL136528, BC089039
    Related
    ENST00000452079.5

  5. NR_033712.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences compared to variant 1.
    Source sequence(s)
    AL136528, BC013872
    Related
    ENST00000418088.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    3735984..3747373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    3247585..3258974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207306.2: Suppressed sequence

    Description
    NM_207306.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version

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