VN1R1 vomeronasal 1 receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: VN1R1provided by HGNC
Official Full Name: vomeronasal 1 receptor 1provided by HGNC
Primary source: HGNC:HGNC:13548
See related: Ensembl:ENSG00000178201 MIM:605234; AllianceGenome:HGNC:13548
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: V1RL1; ZVNH1; ZVNR1; VNR19I1
Summary: Pheromones are chemical signals that elicit specific behavioral responses and physiologic alterations in recipients of the same species. The protein encoded by this gene is similar to pheromone receptors and is primarily localized to the olfactory mucosa. An alternate splice variant of this gene is thought to exist, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Orthologs: all
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Genomic context

Location:: 19q13.43

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (57454790..57457140, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (60551821..60554171, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (57966158..57968508, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the reported association in this study suggests that, as a result of genetic variation, naturally occurring endogenous modulation of VN1R1 function affects women's socio-sexual behavior, and that humans thus communicate via chemo-signaling.
Title: A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior.
Structure and function analyses of the purified GPCR human vomeronasal type 1 receptor 1
Title: Structure and function analyses of the purified GPCR human vomeronasal type 1 receptor 1.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of genotype prevalence. (HuGE Navigator)
Title: Association study of human VN1R1 pheromone receptor gene alleles and gender.
The human VN1R1 gene are unlikely to be associated with gender and hence to contribute to distinct gender-specific behavior.
Title: Association study of human VN1R1 pheromone receptor gene alleles and gender.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables pheromone receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in response to pheromone	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of chemical stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vomeronasal type-1 receptor 1

Names: G-protein coupled receptor GPCR24; V1R-like 1; V1r-like receptor 1; V3r-related gene protein; hGPCR24; vomeronasal olfactory receptor chromosome 19 subtype I member 1; vomeronasal olfactory receptor, (chromosome 19) subtype I, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.