DENND11 DENN domain containing 11 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DENND11provided by HGNC
Official Full Name: DENN domain containing 11provided by HGNC
Primary source: HGNC:HGNC:29472
See related: Ensembl:ENSG00000257093 MIM:620122; AllianceGenome:HGNC:29472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LCHN; PRO2561; KIAA1147
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in brain (RPKM 17.1), thyroid (RPKM 13.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (141656728..141702166, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (142972579..143017998, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (141356528..141401966, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH18340 (e-PCR)
- UniSTS:66843

WI-11397 (e-PCR)
- UniSTS:24363

GDB:193149 (e-PCR)
- UniSTS:34100

RH99114 (e-PCR)
- UniSTS:90166

D7S2047E (e-PCR)
- UniSTS:47428

D7S2132E (e-PCR)
- UniSTS:151131

WI-14889 (e-PCR)
- UniSTS:39516

GDB:4585087 (e-PCR)
- UniSTS:14450

D7S810E (e-PCR)
- UniSTS:473203

D1S3699 (e-PCR)
- UniSTS:474277

G19900 (e-PCR)
- UniSTS:3521

A002B37 (e-PCR)
- UniSTS:3522

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DENN domain-containing protein 11

Names: predicted protein of HQ2561; protein LCHN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.