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kirrel3a kirre like nephrin family adhesion molecule 3a [ Danio rerio (zebrafish) ]

Gene ID: 571887, updated on 2-Nov-2024

Summary

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Official Symbol
kirrel3aprovided by ZNC
Official Full Name
kirre like nephrin family adhesion molecule 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091117-44
See related
Ensembl:ENSDARG00000075806 AllianceGenome:ZFIN:ZDB-GENE-091117-44
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-185j22.1
Summary
Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in cell-cell adhesion and synapse assembly. Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human KIRREL3 (kirre like nephrin family adhesion molecule 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See kirrel3a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (39311555..39839540)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (39555056..39918056)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly rectifying channel subfamily J member 1b Neighboring gene decapping enzyme, scavenger Neighboring gene somatolactin beta Neighboring gene v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog pseudogene Neighboring gene uncharacterized LOC137496607 Neighboring gene small fragment nuclease Neighboring gene CXADR like membrane protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis. Neumann-Haefelin E, et al. Hum Mol Genet, 2010 Jun 15. PMID 20233749
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kin of IRRE-like protein 3
Names
Neph2a
kin of IRRE like 3 a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    39311555..39839540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224013.1 → XP_068080114.1  kin of IRRE-like protein 3 isoform X1

  2. XM_695526.9 → XP_700618.5  kin of IRRE-like protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A2R8RME3, A0A8N7UTJ1
    Related
    ENSDARP00000151681.1, ENSDART00000183954.1
    Conserved Domains (7) summary
    cd05759
    Location:139 → 219
    Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)
    cd05898
    Location:391 → 488
    Ig5_KIRREL3; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 protein (also known as Neph2)
    smart00408
    Location:322 → 373
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:27 → 116
    IG_like; Immunoglobulin like
    pfam07679
    Location:308 → 389
    I-set; Immunoglobulin I-set domain
    pfam13895
    Location:227 → 304
    Ig_2; Immunoglobulin domain
    cl11960
    Location:25 → 116
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version

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