U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC39A10 solute carrier family 39 member 10 [ Homo sapiens (human) ]

Gene ID: 57181, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
SLC39A10provided by HGNC
Official Full Name
solute carrier family 39 member 10provided by HGNC
Primary source
HGNC:HGNC:20861
See related
Ensembl:ENSG00000196950 MIM:608733; AllianceGenome:HGNC:20861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIP10; LZT-Hs2
Summary
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in thyroid (RPKM 12.9), brain (RPKM 12.5) and 21 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SLC39A10 in Genome Data Viewer
Location:
2q32.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (195613029..195737700)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (196097362..196222040)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196521682..196602424)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:196434945-196435535 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:196450653-196451242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:196452793-196453292 Neighboring gene long intergenic non-protein coding RNA 1827 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:196477499-196478360 Neighboring gene adenosylhomocysteinase pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16889 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12201 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12199 Neighboring gene RNA, U6 small nuclear 915, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:196559503-196560702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:196569194-196569694 Neighboring gene uncharacterized LOC107985972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:196608945-196609445 Neighboring gene dynein axonemal heavy chain 7 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:196652546-196653745 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:196722945-196724144 Neighboring gene E2F transcription factor 3 pseudogene 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
    Title: SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
  2. The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling.
    Title: The bZIP transcription factor BATF3/ZIP-10 suppresses innate immunity by attenuating PMK-1/p38 signaling.
  3. Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity.
    Title: Functional characterization of SLC39 family members ZIP5 and ZIP10 in overexpressing HEK293 cells reveals selective copper transport activity.
  4. ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway.
    Title: ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway.
  5. The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.
    Title: The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.
  6. Possible involvement of zinc transporter ZIP10 in atopic dermatitis.
    Title: Possible involvement of zinc transporter ZIP10 in atopic dermatitis.
  7. ZIP10 is found in the proximal tubules collecting duct system and has a role in renal zinc transport.
    Title: Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn(2+) transporter.
  8. Slc39a10 plays a role in promoting the survival of macrophages through a Zn/p53-dependent axis in response to inflammatory stimuli.
    Title: Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival.
  9. A significant correlation between ZIP10 mRNA expressions with aggressiveness of RCC.
    Title: Association between ZIP10 gene expression and tumor aggressiveness in renal cell carcinoma.
  10. Zinc and its transporters, ZIP6 and ZIP10, are required for the breast cancer cells motility stimulated with high glucose level, such as in diabetes.
    Title: High glucose level promotes migration behavior of breast cancer cells through zinc and its transporters.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SLC39A10 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of solute carrier family 39 (zinc transporter), member 10 (SLC39A10) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ31108, MGC126565, MGC138428, DKFZp781L10106

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables monoatomic cation:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular monoatomic cation homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
zinc transporter ZIP10
Names
ZIP-10
ZRT/IRT-like protein 10
solute carrier family 39 (metal ion transporter), member 10
solute carrier family 39 (zinc transporter), member 10
zinc transporter 10
zrt- and Irt-like protein 10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127257.2 → NP_001120729.1  zinc transporter ZIP10 precursor

    See identical proteins and their annotated locations for NP_001120729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC013274, AI693720, CR749813
    Consensus CDS
    CCDS33353.1
    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    Related
    ENSP00000386766.3, ENST00000409086.7
    Conserved Domains (1) summary
    pfam02535
    Location:404 → 819
    Zip; ZIP Zinc transporter

  2. NM_020342.3 → NP_065075.1  zinc transporter ZIP10 precursor

    See identical proteins and their annotated locations for NP_065075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC013274, AI693720, AK291241
    Consensus CDS
    CCDS33353.1
    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    Related
    ENSP00000352655.5, ENST00000359634.10
    Conserved Domains (1) summary
    pfam02535
    Location:404 → 819
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    195613029..195737700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511504.3 → XP_011509806.1  zinc transporter ZIP10 isoform X4

    See identical proteins and their annotated locations for XP_011509806.1

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1
    Conserved Domains (1) summary
    pfam02535
    Location:404 → 819
    Zip; ZIP Zinc transporter

  2. XM_005246689.5 → XP_005246746.3  zinc transporter ZIP10 isoform X1

  3. XM_047445143.1 → XP_047301099.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

  4. XM_011511507.3 → XP_011509809.2  zinc transporter ZIP10 isoform X5

  5. XM_017004523.2 → XP_016860012.2  zinc transporter ZIP10 isoform X6

  6. XM_047445144.1 → XP_047301100.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

  7. XM_047445141.1 → XP_047301097.1  zinc transporter ZIP10 isoform X2

  8. XM_047445142.1 → XP_047301098.1  zinc transporter ZIP10 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    196097362..196222040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343084.1 → XP_054199059.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

  2. XM_054343085.1 → XP_054199060.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

  3. XM_054343081.1 → XP_054199056.1  zinc transporter ZIP10 isoform X7

  4. XM_054343087.1 → XP_054199062.1  zinc transporter ZIP10 isoform X8

  5. XM_054343088.1 → XP_054199063.1  zinc transporter ZIP10 isoform X9

  6. XM_054343086.1 → XP_054199061.1  zinc transporter ZIP10 isoform X4

    UniProtKB/Swiss-Prot
    A8K5C6, B4DGU0, Q3MJA4, Q68CR5, Q6DKH6, Q9ULF5, Q9Y3Z1

  7. XM_054343082.1 → XP_054199057.1  zinc transporter ZIP10 isoform X2

  8. XM_054343083.1 → XP_054199058.1  zinc transporter ZIP10 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULF5.2 GenPept UniProtKB/Swiss-Prot:Q9ULF5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous