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kank2 KN motif and ankyrin repeat domains 2 [ Danio rerio (zebrafish) ]

Gene ID: 571549, updated on 2-Nov-2024

Summary

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Official Symbol
kank2provided by ZNC
Official Full Name
KN motif and ankyrin repeat domains 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040724-121
See related
Ensembl:ENSDARG00000018393 AllianceGenome:ZFIN:ZDB-GENE-040724-121
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dZ118J2.12; si:ch73-108m21.1; si:busm1-118j2.12
Summary
Acts upstream of or within glomerular basement membrane development and podocyte development. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in head; nervous system; pectoral fin; segmental plate; and trunk. Human ortholog(s) of this gene implicated in nephrotic syndrome type 16 and palmoplantar keratoderma and woolly hair. Orthologous to human KANK2 (KN motif and ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See kank2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (55154603..55213981, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (54907025..54959426, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene hemoglobin, alpha embryonic 1.3 Neighboring gene hemoglobin alpha embryonic-3 Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin like 8 Neighboring gene uncharacterized LOC101884549

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. KANK deficiency leads to podocyte dysfunction and nephrotic syndrome. Gee HY, et al. J Clin Invest, 2015 Jun. PMID 25961457, Free PMC Article
  2. NBP, a zebrafish homolog of human Kank3, is a novel Numb interactor essential for epidermal integrity and neurulation. Boggetti B, et al. Dev Biol, 2012 May 1. PMID 22387208
  3. Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Hensley MR, et al. Sci Rep, 2016 Jun 13. PMID 27292017, Free PMC Article
  4. The timing of Timezyme diversification in vertebrates. Cazaméa-Catalan D, et al. PLoS One, 2014. PMID 25486407, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glomerular basement membrane development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of vitamin D receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within podocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
KN motif and ankyrin repeat domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305620.1 → NP_001292549.1  KN motif and ankyrin repeat domain-containing protein 2

    See identical proteins and their annotated locations for NP_001292549.1

    Status: VALIDATED

    Source sequence(s)
    CU464181
    UniProtKB/Swiss-Prot
    X1WE18
    UniProtKB/TrEMBL
    A0A8M9PIR3
    Related
    ENSDARP00000146055.1, ENSDART00000179903.1
    Conserved Domains (5) summary
    cd00204
    Location:890 → 1021
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:895 → 964
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:34 → 72
    KN_motif; KN motif
    pfam12796
    Location:1005 → 1059
    Ank_2; Ankyrin repeats (3 copies)
    cl25496
    Location:607 → 899
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    55154603..55213981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164339.5 → XP_005164396.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005164396.1

    UniProtKB/Swiss-Prot
    X1WE18
    UniProtKB/TrEMBL
    A0A8M9PIR3
    Related
    ENSDARP00000128469.1, ENSDART00000154031.2
    Conserved Domains (5) summary
    cd00204
    Location:890 → 1021
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:895 → 964
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:34 → 72
    KN_motif; KN motif
    pfam12796
    Location:1005 → 1059
    Ank_2; Ankyrin repeats (3 copies)
    cl25496
    Location:607 → 899
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. XM_021471168.2 → XP_021326843.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    X1WE18
    UniProtKB/TrEMBL
    A0A8M9PIR3
    Conserved Domains (5) summary
    cd00204
    Location:890 → 1021
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:895 → 964
    ANK; ANK repeat [structural motif]
    pfam12075
    Location:34 → 72
    KN_motif; KN motif
    pfam12796
    Location:1005 → 1059
    Ank_2; Ankyrin repeats (3 copies)
    cl25496
    Location:607 → 899
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
X1WE18.1 GenPept UniProtKB/Swiss-Prot:X1WE18

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