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POLY polyprotein;truncated polyprotein NS1 prime;truncated polyprotein WARF4 [ West Nile virus ]

Gene ID: 5714902, updated on 22-Sep-2023

Summary

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Gene symbol
POLY
Gene description
polyprotein;truncated polyprotein NS1 prime;truncated polyprotein WARF4
Locus tag
WNVNY99_gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
West Nile virus (strain: NY99, isolate: 385-99)
Lineage
Viruses; Riboviria; Flaviviridae; Flavivirus
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Genomic context

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Sequence:
NC_009942.1 (97..10398)

NC_009942.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009942.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identifying the region influencing the cis-mode of maturation of West Nile (Sarafend) virus using chimeric infectious clones. Li J, et al. Biochem Biophys Res Commun, 2005 Aug 26. PMID 16018972
  2. Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranes. Lobigs M, et al. J Virol, 2004 Jan. PMID 14671099, Free PMC Article
  3. Recombinant canarypoxvirus vaccine carrying the prM/E genes of West Nile virus protects horses against a West Nile virus-mosquito challenge. Minke JM, et al. Arch Virol Suppl, 2004. PMID 15119777
  4. Solution structure and antibody binding studies of the envelope protein domain III from the New York strain of West Nile virus. Volk DE, et al. J Biol Chem, 2004 Sep 10. PMID 15190071
  5. West Nile virus core protein; tetramer structure and ribbon formation. Dokland T, et al. Structure, 2004 Jul. PMID 15242592, Free PMC Article

See all (165) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.
    Title: A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.
  2. Remodeling of the Actin Network Associated with the Non-Structural Protein 1 (NS1) of West Nile Virus and Formation of NS1-Containing Tunneling Nanotubes.
    Title: Remodeling of the Actin Network Associated with the Non-Structural Protein 1 (NS1) of West Nile Virus and Formation of NS1-Containing Tunneling Nanotubes.
  3. Role of NS1 and TLR3 in Pathogenesis and Immunity of WNV.
    Title: Role of NS1 and TLR3 in Pathogenesis and Immunity of WNV.
  4. Conserved NS1 protein is species-specific for Saint Louis Encephalitis Virus and West Nile virus.
    Title: Production of recombinant NS1 protein and its possible use in encephalitic flavivirus differential diagnosis.
  5. findings show that differences in the NS1-2B region contribute to avian pathogenicity in a manner that is independent of and additive with the NS3-249 mutation. Additionally, NS1-2B residues were found to alter temperature sensitivity when grown in avian cells
    Title: West Nile Virus Temperature Sensitivity and Avian Virulence Are Modulated by NS1-2B Polymorphisms.
  6. NS1-P250L mutation was associated with a significant attenuation of virulence in mice compared to the wild-type.
    Title: In Vitro and in Vivo Evaluation of Mutations in the NS Region of Lineage 2 West Nile Virus Associated with Neuroinvasiveness in a Mammalian Model.
  7. The authors demonstrated that improved secretion of virus particles in the presence of prM I22V and L72S substitutions was contributed by more efficient prM/E heterodimerization.
    Title: The I22V and L72S substitutions in West Nile virus prM protein promote enhanced prM/E heterodimerisation and nucleocapsid incorporation.
  8. N-terminus of NS4A contributes to correct folding and stability, and is essential for replication.
    Title: Conserved amino acids within the N-terminus of the West Nile virus NS4A protein contribute to virus replication, protein stability and membrane proliferation.
  9. Missense mutation of the C-terminus of the NS4A confers resistance to superinfection.
    Title: A positively selected mutation in the WNV 2K peptide confers resistance to superinfection exclusion in vivo.
  10. The individual amino acid changes P320S and M333V in West Nile virus NS1 restored TLR3 signaling in virus-infected HeLa cells, however, virus replication was also attenuated.
    Title: Abrogation of TLR3 inhibition by discrete amino acid changes in the C-terminal half of the West Nile virus NS1 protein.
Submit: New GeneRIF Correction See all GeneRIFs (27)

General protein information

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Preferred Names
polyprotein;truncated polyprotein NS1 prime;truncated polyprotein WARF4
Names
capsid protein C
anchored capsid protein ancC
membrane glycoprotein precursor prM
envelope protein E
nonstructural protein NS1
nonstructural protein NS2A
nonstructural protein NS2B
nonstructural protein NS3
nonstructural protein NS4A
nonstructural protein NS4B
RNA-dependent RNA polymerase NS5
membrane glycoprotein M
protein 2K
protein pr
N-NS4B/WARF4
nonstructural protein NS1 prime
YP_006485883.2
  • NS1'; Truncated version of polyprotein that will be produced when programmed ribosomal frameshifting occurs at nt 3552; Truncated version of polyprotein and NS1' protein have been added and annotated with the kind help of Dr. David Karlin (Department of Zoology, University of Oxford, UK) and Dr. Andrew Firth (Department of Pathology, University of Cambridge, UK)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009942.1 Reference assembly

    Range
    97..10398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001527877.1 polyprotein [West Nile virus]

    See identical proteins and their annotated locations for YP_001527877.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Q6P4
    UniProtKB/TrEMBL
    A0A3G5ALR9, Q3HM13, Q5I6T5, Q5MAL4
    Conserved Domains (27) summary
    pfam01003
    Location:6 → 105
    Flavi_capsid; Flavivirus capsid protein C
    pfam01003
    Location:6 → 123
    Flavi_capsid; Flavivirus capsid protein C
    pfam01004
    Location:98 → 167
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:7 → 81
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam01004
    Location:98 → 167
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:7 → 81
    Flavi_propep; Flavivirus polyprotein propeptide
    cd12149
    Location:308 → 400
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:405 → 501
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam00869
    Location:3 → 299
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00948
    Location:2 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam01005
    Location:12 → 164
    Flavi_NS2A; Flavivirus non-structural protein NS2A
    pfam01002
    Location:6 → 131
    Flavi_NS2B; Flavivirus non-structural protein NS2B
    smart00487
    Location:181 → 352
    DEXDc; DEAD-like helicases superfamily
    pfam00949
    Location:19 → 167
    Peptidase_S7; Peptidase S7, Flavivirus NS3 serine protease
    pfam07652
    Location:186 → 331
    Flavi_DEAD; Flavivirus DEAD domain
    cl21455
    Location:357 → 465
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    pfam01350
    Location:5 → 147
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam01350
    Location:5 → 147
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam01349
    Location:1 → 246
    Flavi_NS4B; Flavivirus non-structural protein NS4B
    pfam00972
    Location:255 → 894
    Flavi_NS5; Flavivirus RNA-directed RNA polymerase
    pfam01728
    Location:55 → 224
    FtsJ; FtsJ-like methyltransferase
    pfam01004
    Location:98 → 167
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:7 → 81
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam01004
    Location:98 → 167
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:7 → 81
    Flavi_propep; Flavivirus polyprotein propeptide
    pfam01350
    Location:5 → 147
    Flavi_NS4A; Flavivirus non-structural protein NS4A
    pfam01350
    Location:5 → 147
    Flavi_NS4A; Flavivirus non-structural protein NS4A

  2. YP_009246337.1 truncated flavivirus polyprotein WARF4 [West Nile virus]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1B1WVP6

  3. YP_009246339.1 N-NS4B/WARF4

  4. YP_006485883.2 truncated flavivirus polyprotein NS1 prime [West Nile virus]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1B1WV63
    Conserved Domains (7) summary
    cd12149
    Location:598 → 690
    Flavi_E_C; Immunoglobulin-like domain III (C-terminal domain) of Flavivirus envelope glycoprotein E
    TIGR04240
    Location:695 → 791
    flavi_E_stem; flavivirus envelope glycoprotein E, stem/anchor domain
    pfam01003
    Location:6 → 123
    Flavi_capsid; Flavivirus capsid protein C
    pfam00869
    Location:293 → 589
    Flavi_glycoprot; Flavivirus glycoprotein, central and dimerization domains
    pfam00948
    Location:793 → 1143
    Flavi_NS1; Flavivirus non-structural Protein NS1
    pfam01004
    Location:221 → 290
    Flavi_M; Flavivirus envelope glycoprotein M
    pfam01570
    Location:130 → 204
    Flavi_propep; Flavivirus polyprotein propeptide

  5. YP_009246338.1 nonstructural protein NS1 prime

    Conserved Domains (1) summary
    pfam00948
    Location:2 → 352
    Flavi_NS1; Flavivirus non-structural Protein NS1
Nucleotide Protein
Heading Accession and Version

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