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plekha7a pleckstrin homology domain containing, family A member 7a [ Danio rerio (zebrafish) ]

Gene ID: 571486, updated on 2-Nov-2024

Summary

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Official Symbol
plekha7aprovided by ZNC
Official Full Name
pleckstrin homology domain containing, family A member 7aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050419-75
See related
Ensembl:ENSDARG00000060813 AllianceGenome:ZFIN:ZDB-GENE-050419-75
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
plekha7; si:dkey-29p10.1
Summary
Predicted to enable delta-catenin binding activity. Acts upstream of or within cardiac muscle cell differentiation and regulation of heart contraction. Predicted to be located in centrosome and zonula adherens. Is expressed in cardiovascular system and tail bud. Orthologous to human PLEKHA7 (pleckstrin homology domain containing A7). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See plekha7a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (27101443..27306100)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (27119124..27323115)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Neighboring gene protein phosphatase 1, regulatory subunit 15B Neighboring gene zgc:56106 Neighboring gene CD81 molecule b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Motoneurons are essential for vascular pathfinding. Lim AH, et al. Development, 2011 Sep. PMID 21828101, Free PMC Article
  2. Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Wythe JD, et al. Dis Model Mech, 2011 Sep. PMID 21628396, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hadp1 modulates Ca(2+) handling in the heart through its interaction with phosphatidylinositols.[Hadp1]
    Title: Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables delta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zonula adherens maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in zonula adherens ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 7
Names
PH domain-containing family A member 7
hadp1
heart adapter protein 1
heart adaptor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136243.2 → NP_001129715.2  pleckstrin homology domain-containing family A member 7

    Status: VALIDATED

    Source sequence(s)
    BX640463, CR391988

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    27101443..27306100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214821.1 → XP_068070922.1  pleckstrin homology domain-containing family A member 7 isoform X2

  2. XM_068214820.1 → XP_068070921.1  pleckstrin homology domain-containing family A member 7 isoform X1

  3. XM_068214823.1 → XP_068070924.1  pleckstrin homology domain-containing family A member 7 isoform X4

    Related
    ENSDARP00000133544.2, ENSDART00000171128.2

  4. XM_068214822.1 → XP_068070923.1  pleckstrin homology domain-containing family A member 7 isoform X3

  5. XM_068214826.1 → XP_068070927.1  pleckstrin homology domain-containing family A member 7 isoform X7

  6. XM_068214824.1 → XP_068070925.1  pleckstrin homology domain-containing family A member 7 isoform X5

  7. XM_068214828.1 → XP_068070929.1  pleckstrin homology domain-containing family A member 7 isoform X9

    Related
    ENSDARP00000080529.6, ENSDART00000086094.6

  8. XM_068214832.1 → XP_068070933.1  pleckstrin homology domain-containing family A member 7 isoform X12

  9. XM_068214825.1 → XP_068070926.1  pleckstrin homology domain-containing family A member 7 isoform X6

  10. XM_068214827.1 → XP_068070928.1  pleckstrin homology domain-containing family A member 7 isoform X8

  11. XM_068214831.1 → XP_068070932.1  pleckstrin homology domain-containing family A member 7 isoform X11

  12. XM_068214830.1 → XP_068070931.1  pleckstrin homology domain-containing family A member 7 isoform X10

  13. XM_068214829.1 → XP_068070930.1  pleckstrin homology domain-containing family A member 7 isoform X10

    Related
    ENSDARP00000098382.2, ENSDART00000111450.4

  14. XM_068214833.1 → XP_068070934.1  pleckstrin homology domain-containing family A member 7 isoform X13

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395030.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    284623..285132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B6RSP1.2 GenPept UniProtKB/Swiss-Prot:B6RSP1

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