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gusb glucuronidase, beta [ Danio rerio (zebrafish) ]

Gene ID: 571441, updated on 18-Sep-2024

Summary

Official Symbol
gusbprovided by ZNC
Official Full Name
glucuronidase, betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070705-256
See related
Ensembl:ENSDARG00000063126 AllianceGenome:ZFIN:ZDB-GENE-070705-256
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ct573103.7; si:ch211-160e1.7
Summary
Predicted to enable beta-glucuronidase activity and carbohydrate binding activity. Predicted to be involved in glucuronoside catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in lysosome. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Sly syndrome. Orthologous to human GUSB (glucuronidase beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See gusb in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (2068883..2112087, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (1804360..1846773, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 Neighboring gene nuclear protein 1a Neighboring gene uncharacterized LOC137495508 Neighboring gene carbonic anhydrase IV a Neighboring gene myotubularin related protein 4 Neighboring gene uncharacterized LOC103910293 Neighboring gene citron rho-interacting serine/threonine kinase a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables beta-glucuronidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables beta-glucuronidase activity IEA
Inferred from Electronic Annotation
more info
 
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
beta-glucuronidase
XP_009299404.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    2068883..2112087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301129.4XP_009299404.1  beta-glucuronidase

    UniProtKB/TrEMBL
    A0A8M3AZ75, F1QGS9
    Related
    ENSDARP00000086365.5, ENSDART00000091932.6
    Conserved Domains (4) summary
    PRK10150
    Location:30630
    PRK10150; beta-D-glucuronidase; Provisional
    pfam00703
    Location:228326
    Glyco_hydro_2; Glycosyl hydrolases family 2
    pfam02837
    Location:39226
    Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
    cl23725
    Location:328630
    Glyco_hydro_1; Glycosyl hydrolase family 1