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LPAR5 lysophosphatidic acid receptor 5 [ Homo sapiens (human) ]

Gene ID: 57121, updated on 5-Mar-2024

Summary

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Official Symbol
LPAR5provided by HGNC
Official Full Name
lysophosphatidic acid receptor 5provided by HGNC
Primary source
HGNC:HGNC:13307
See related
Ensembl:ENSG00000184574 MIM:606926; AllianceGenome:HGNC:13307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPA5; GPR92; GPR93; KPG_010
Summary
This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
Expression
Broad expression in colon (RPKM 5.6), lymph node (RPKM 4.4) and 23 other tissues See more
Orthologs
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Genomic context

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See LPAR5 in Genome Data Viewer
Location:
12p13.31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (6618835..6635959, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (6629192..6646324, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6728001..6745125, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 4 Neighboring gene small Cajal body-specific RNA 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6705357-6705858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6705859-6706358 Neighboring gene uncharacterized LOC124902867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5868 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5869 Neighboring gene CRISPRi-validated cis-regulatory element chr12.325 Neighboring gene uncharacterized LOC105369631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6729027-6729548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:6729549-6730069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5871 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:6756019-6756532 Neighboring gene acrosin binding protein Neighboring gene MPRA-validated peak1551 silencer Neighboring gene inhibitor of growth family member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5874

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer. Dacheux MA, et al. Pharmacol Ther, 2023 May. PMID 37061203, Free PMC Article
  2. Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer. Zhang B, et al. Sci Rep, 2023 Apr 10. PMID 37037831, Free PMC Article
  3. Infiltration of LPAR5(+) macrophages in osteosarcoma tumor microenvironment predicts better outcomes. He Y, et al. Front Immunol, 2022. PMID 36591220, Free PMC Article
  4. LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway. Sun XY, et al. J Transl Med, 2022 Oct 5. PMID 36199069, Free PMC Article
  5. LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β. Zhao WJ, et al. Cancer Sci, 2021 Apr. PMID 33540491, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid receptor 5.
    Title: Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid receptor 5.
  2. Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer.
    Title: Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer.
  3. Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer.
    Title: Potential role of LPAR5 gene in prognosis and immunity of thyroid papillary carcinoma and pan-cancer.
  4. Infiltration of LPAR5[+] macrophages in osteosarcoma tumor microenvironment predicts better outcomes.
    Title: Infiltration of LPAR5(+) macrophages in osteosarcoma tumor microenvironment predicts better outcomes.
  5. LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway.
    Title: LPAR5 confers radioresistance to cancer cells associated with EMT activation via the ERK/Snail pathway.
  6. Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
    Title: Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
  7. Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5.
    Title: Lysophosphatidic acid mediates the pathogenesis of psoriasis by activating keratinocytes through LPAR5.
  8. Interference with lysophosphatidic acid receptor 5 ameliorates oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury by inactivating NOD-like receptor family, pyrin domain containing 3 inflammasome signaling.
    Title: Interference with lysophosphatidic acid receptor 5 ameliorates oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury by inactivating NOD-like receptor family, pyrin domain containing 3 inflammasome signaling.
  9. LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11.
    Title: LPAR5 stimulates the malignant progression of non-small-cell lung carcinoma by upregulating MLLT11.
  10. LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110beta.
    Title: LPAR5 promotes thyroid carcinoma cell proliferation and migration by activating class IA PI3K catalytic subunit p110β.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: ACRBP

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in behavioral response to pain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of CREB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
lysophosphatidic acid receptor 5
Names
G protein-coupled receptor 92
G-protein coupled receptor 93
LPA receptor 5
LPA-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142961.1 → NP_001136433.1  lysophosphatidic acid receptor 5

    See identical proteins and their annotated locations for NP_001136433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC072394, DC328599
    Consensus CDS
    CCDS8553.1
    UniProtKB/Swiss-Prot
    Q9H1C0
    UniProtKB/TrEMBL
    B4DZ78, Q5KU18
    Related
    ENSP00000393098.1, ENST00000431922.1
    Conserved Domains (2) summary
    cd14964
    Location:25 → 49
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 308
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_020400.6 → NP_065133.1  lysophosphatidic acid receptor 5

    See identical proteins and their annotated locations for NP_065133.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC072394
    Consensus CDS
    CCDS8553.1
    UniProtKB/Swiss-Prot
    Q9H1C0
    UniProtKB/TrEMBL
    B4DZ78, Q5KU18
    Related
    ENSP00000327875.4, ENST00000329858.9
    Conserved Domains (2) summary
    cd14964
    Location:25 → 49
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:23 → 308
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    6618835..6635959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    6629192..6646324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H1C0.1 GenPept UniProtKB/Swiss-Prot:Q9H1C0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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