TIGAR TP53 induced glycolysis regulatory phosphatase [Homo sapiens (human)] - Gene

Summary

Official Symbol: TIGARprovided by HGNC
Official Full Name: TP53 induced glycolysis regulatory phosphataseprovided by HGNC
Primary source: HGNC:HGNC:1185
See related: Ensembl:ENSG00000078237 MIM:610775; AllianceGenome:HGNC:1185
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FR2BP; C12orf5
Summary: This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in urinary bladder (RPKM 2.3), colon (RPKM 2.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12p13.32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (4321213..4360028)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (4327996..4366805)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (4430379..4469194)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TIGAR Protects Against Adenine-Induced Ferroptosis in Human Proximal Tubular Epithelial Cells by Activating the mTOR/S6KP70 Axis.
Title: TIGAR Protects Against Adenine-Induced Ferroptosis in Human Proximal Tubular Epithelial Cells by Activating the mTOR/S6KP70 Axis.
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Title: Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway.
Title: TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway.
The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells.
Title: The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells.
Targeting neuroinflammation to treat cerebral ischemia - The role of TIGAR/NADPH axis.
Title: Targeting neuroinflammation to treat cerebral ischemia - The role of TIGAR/NADPH axis.
TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation.
Title: TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation.
Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma.
Title: Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma.
TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy.
Title: TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy.
Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway.
Title: Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway.
TIGAR expression is modulated during pancreatic ductal adenocarcinoma development
Title: Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G41261 (e-PCR)
- UniSTS:36354

GDB:434012 (e-PCR)
- UniSTS:157204

G41262 (e-PCR)
- UniSTS:72470

SHGC-32311 (e-PCR)
- UniSTS:5415

L18426 (e-PCR)
- UniSTS:34648

STS-N39260 (e-PCR)
- UniSTS:14428

D12S1725 (e-PCR), detects polymorphism
- UniSTS:82579

D5S1597E (e-PCR)
- UniSTS:151019

L17676 (e-PCR)
- UniSTS:10494

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables fructose-2,6-bisphosphate 2-phosphatase activity	EXP Inferred from Experiment more info	PubMed
enables fructose-2,6-bisphosphate 2-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-2,6-bisphosphate 2-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cobalt ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose 2,6-bisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose catabolic process to lactate via pyruvate	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in intestinal epithelial cell development	IEA Inferred from Electronic Annotation more info
involved_in mitophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glucose catabolic process to lactate via pyruvate	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of mitophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hexokinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in reactive oxygen species metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of pentose-phosphate shunt	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of pentose-phosphate shunt	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fructose-2,6-bisphosphatase TIGAR

Names: TP53-induced glycolysis and apoptosis regulator; fructose-2,6-bisphosphate 2-phosphatase; probable fructose-2,6-bisphosphatase TIGAR; transactivated by NS3TP2 protein

NP_065108.1

EC 3.1.3.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.