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TRIM49 tripartite motif containing 49 [ Homo sapiens (human) ]

Gene ID: 57093, updated on 2-Nov-2024

Summary

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Official Symbol
TRIM49provided by HGNC
Official Full Name
tripartite motif containing 49provided by HGNC
Primary source
HGNC:HGNC:13431
See related
Ensembl:ENSG00000168930 MIM:606124; AllianceGenome:HGNC:13431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF18; TRIM49A; TRIM49L2
Summary
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See TRIM49 in Genome Data Viewer
Location:
11q14.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (89766451..89808575, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89717331..89728251, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89530823..89541743, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cell adhesion associated, oncogene regulated pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:89477010-89477565 Neighboring gene UBTF like 2 (pseudogene) Neighboring gene tripartite motif containing 64D, pseudogene Neighboring gene ANKRD33B pseudogene 7 Neighboring gene tripartite motif containing 64B pseudogene Neighboring gene tripartite motif containing 53B, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach(1). Yoshikawa T, et al. Biochim Biophys Acta, 2000 Oct 2. PMID 11018261
  2. Expression, purification, and characterization of the TRIM49 protein. Guimarães DS, et al. Protein Expr Purif, 2018 Mar. PMID 29107100
  3. Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination. Tikoo S, et al. EMBO J, 2013 Jun 12. PMID 23708797, Free PMC Article
  4. Identification of a genomic reservoir for new TRIM genes in primate genomes. Han K, et al. PLoS Genet, 2011 Dec. PMID 22144910, Free PMC Article
  5. TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis. Chauhan S, et al. Dev Cell, 2016 Oct 10. PMID 27693506, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 49
Names
ring finger protein 18
testis-specific RING Finger protein
testis-specific ring-finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020358.2 → NP_065091.1  tripartite motif-containing protein 49

    See identical proteins and their annotated locations for NP_065091.1

    Status: REVIEWED

    Source sequence(s)
    AP004833
    Consensus CDS
    CCDS8287.1
    UniProtKB/Swiss-Prot
    P0CI25
    Related
    ENSP00000327604.1, ENST00000329758.5
    Conserved Domains (2) summary
    cd16603
    Location:12 → 57
    RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cl02614
    Location:285 → 448
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    89766451..89808575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448617.2 → XP_024304385.1  tripartite motif-containing protein 49 isoform X1

    Conserved Domains (2) summary
    cd16603
    Location:12 → 57
    RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cl02614
    Location:285 → 441
    SPRY; SPRY domain

  2. XM_017018027.3 → XP_016873516.1  tripartite motif-containing protein 49 isoform X2

    UniProtKB/TrEMBL
    E9PK69
    Related
    ENSP00000431618.2, ENST00000532501.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    89717331..89728251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369444.1 → XP_054225419.1  tripartite motif-containing protein 49 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CI25.1 GenPept UniProtKB/Swiss-Prot:P0CI25

Gene LinkOut

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