c7b complement component 7b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: c7bprovided by ZNC
Official Full Name: complement component 7bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021120-1
See related: Ensembl:ENSDARG00000057121 AllianceGenome:ZFIN:ZDB-GENE-021120-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: c7; cb349; wu:fa01f03; si:dkey-246j23.5
Summary: Predicted to be involved in complement activation. Predicted to act upstream of or within complement activation, classical pathway; innate immune response; and killing of cells of another organism. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Is expressed in central nervous system and yolk syncytial layer. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (20901280..20915291)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (20864654..20878711)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd15a03.x1 (e-PCR)
- UniSTS:195201

aa497156 (e-PCR)
- UniSTS:186866

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within killing of cells of another organism	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
part_of membrane attack complex	IBA Inferred from Biological aspect of Ancestor more info
part_of membrane attack complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: complement component 7b

Names: C7-1; complement component 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001386266.1 → NP_001373195.1 complement component 7b precursor

Status: VALIDATED

Source sequence(s)

BX511186

UniProtKB/TrEMBL

A0A8M9PWA7, F1QF24, F1QKJ3

Related

ENSDARP00000114284.1, ENSDART00000132741.2

Conserved Domains (6) summary

PHA02639
Location:563 → 689

PHA02639; EEV host range protein; Provisional

smart00209
Location:40 → 90

TSP1; Thrombospondin type 1 repeats

cd00112
Location:96 → 128

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01823
Location:227 → 443

MACPF; MAC/Perforin domain

pfam18434
Location:783 → 831

Kazal_3; Kazal-type serine protease inhibitor domain

cl20168
Location:697 → 757

Kazal_3; Kazal-type serine protease inhibitor domain