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apoc1 apolipoprotein C-I [ Danio rerio (zebrafish) ]

Gene ID: 570638, updated on 2-Nov-2024

Summary

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Official Symbol
apoc1provided by ZNC
Official Full Name
apolipoprotein C-Iprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1074
See related
Ensembl:ENSDARG00000092170 AllianceGenome:ZFIN:ZDB-GENE-030131-1074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
apoc1l; fb58g10; wu:fb58g10
Summary
Predicted to enable fatty acid binding activity and phospholipase inhibitor activity. Acts upstream of or within cell migration involved in gastrulation. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Is expressed in DEL; blastoderm; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease and obesity. Orthologous to human APOC1 (apolipoprotein C1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See apoc1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (23972127..23973723)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (24057095..24058691)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein A-IV b, tandem duplicate 2 Neighboring gene apolipoprotein Eb Neighboring gene apolipoprotein C-IV Neighboring gene apolipoprotein A-II

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish. Wang Y, et al. Sci China Life Sci, 2013 Nov. PMID 24203452
  2. Molecular cloning and expression characterization of ApoC-I in the orange-spotted grouper. Wang Y, et al. Fish Physiol Biochem, 2008 Dec. PMID 18958591
  3. Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. Thiel WA, et al. Biol Open, 2022 Jan 15. PMID 34878094, Free PMC Article
  4. BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development. Wang Y, et al. Gene, 2015 Jan 10. PMID 25445289
  5. MicroRNA-146 function in the innate immune transcriptome response of zebrafish embryos to Salmonella typhimurium infection. Ordas A, et al. BMC Genomics, 2013 Oct 10. PMID 24112639, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that apoc1 expression is induced by bone morphogenetic proteins (BMPs) signaling during zebrafish embryonic development.
    Title: BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of very-low-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very-low-density lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of high-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of very-low-density lipoprotein particle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
apolipoprotein C-I
Names
apolipoprotein C-I like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291886.1 → NP_001278815.1  apolipoprotein C-I isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BC162528, CN321250, EH489275
    UniProtKB/TrEMBL
    A0A8M1P660, E9QDI1
    Related
    ENSDARP00000121190.1, ENSDART00000145330.2
    Conserved Domains (1) summary
    pfam04691
    Location:24 → 83
    ApoC-I; Apolipoprotein C-I (ApoC-1)

  2. NM_001291887.1 → NP_001278816.1  apolipoprotein C-I isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    CN321250, EH489275
    UniProtKB/TrEMBL
    A0A8M1P0R3, E9QFX0
    Related
    ENSDARP00000118222.1, ENSDART00000132742.3
    Conserved Domains (1) summary
    pfam04691
    Location:23 → 82
    ApoC-I; Apolipoprotein C-I (ApoC-1)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    23972127..23973723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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