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sord sorbitol dehydrogenase [ Danio rerio (zebrafish) ]

Gene ID: 570613, updated on 2-Nov-2024

Summary

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Official Symbol
sordprovided by ZNC
Official Full Name
sorbitol dehydrogenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1231
See related
Ensembl:ENSDARG00000053405 AllianceGenome:ZFIN:ZDB-GENE-040426-1231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63674
Summary
Predicted to enable L-iditol 2-dehydrogenase (NAD+) activity. Predicted to be involved in sorbitol catabolic process. Predicted to be located in mitochondrial membrane and motile cilium. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See sord in Genome Data Viewer
Location:
chromosome: 7
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (30923283..30926009, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (30652133..30654859, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene amyloid beta (A4) precursor protein-binding, family A, member 2b Neighboring gene methylmalonyl CoA epimerase Neighboring gene si:dkey-1h4.4 Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene tight junction protein 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model. Li Y, et al. Dis Model Mech, 2019 Oct 17. PMID 31515263, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC174502

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-iditol 2-dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sorbitol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorbitol dehydrogenase
NP_001165890.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172419.2 → NP_001165890.1  sorbitol dehydrogenase

    Status: VALIDATED

    Source sequence(s)
    BI984355, DN768503, EH554090, EH605650
    UniProtKB/TrEMBL
    A0A8M1NTC2, F1Q713
    Related
    ENSDARP00000069904.3, ENSDART00000075421.5
    Conserved Domains (2) summary
    cd05285
    Location:7 → 347
    sorbitol_DH; Sorbitol dehydrogenase
    PLN02702
    Location:4 → 344
    PLN02702; L-idonate 5-dehydrogenase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    30923283..30926009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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