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g6pd glucose-6-phosphate dehydrogenase [ Danio rerio (zebrafish) ]

Gene ID: 570579, updated on 14-Nov-2024

Summary

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Official Symbol
g6pdprovided by ZNC
Official Full Name
glucose-6-phosphate dehydrogenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070508-4
See related
Ensembl:ENSDARG00000071065 AllianceGenome:ZFIN:ZDB-GENE-070508-4
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fj78b06; wu:fj78b06; si:dkey-90a13.8
Summary
Enables UDP-glucose 6-dehydrogenase activity and glucose-6-phosphate dehydrogenase activity. Acts upstream of or within epiboly. Predicted to be active in cytosol. Used to study hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See g6pd in Genome Data Viewer
Location:
chromosome: 23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (13844920..13874758, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (14088843..14118717, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene leiomodin 3 (fetal) Neighboring gene N-alpha-acetyltransferase 10, NatA catalytic subuni Neighboring gene uncharacterized LOC108181454 Neighboring gene sperm microtubule inner protein 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae. Wang X, et al. Phytomedicine, 2022 Jul 20. PMID 35576740, Free PMC Article
  2. A model of glucose-6-phosphate dehydrogenase deficiency in the zebrafish. Patrinostro X, et al. Exp Hematol, 2013 Aug. PMID 23603363, Free PMC Article
  3. Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model. Arogbokun O, et al. Sci Rep, 2020 Nov 5. PMID 33154437, Free PMC Article
  4. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Hwang S, et al. Nat Commun, 2018 Oct 2. PMID 30279493, Free PMC Article
  5. The 3'UTRs of Myelin Basic Protein mRNAs Regulate Transport, Local Translation and Sensitivity to Neuronal Activity in Zebrafish. Torvund-Jensen J, et al. Front Mol Neurosci, 2018. PMID 29946237, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
    Title: The vitamin B6-regulated enzymes PYGL and G6PD fuel NADPH oxidases to promote skin inflammation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose 6-dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucose-6-phosphate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epiboly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-6-phosphate 1-dehydrogenase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    13844920..13874758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_694076.9 → XP_699168.3  glucose-6-phosphate 1-dehydrogenase isoform X3

    UniProtKB/TrEMBL
    A0A8M9PT34, F6NHI0
    Related
    ENSDARP00000115363.1, ENSDART00000138696.2
    Conserved Domains (1) summary
    cl27363
    Location:37 → 523
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  2. XM_005162010.5 → XP_005162067.1  glucose-6-phosphate 1-dehydrogenase isoform X1

    UniProtKB/TrEMBL
    A0A8M2B959
    Conserved Domains (1) summary
    cl27363
    Location:48 → 534
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  3. XM_009296703.4 → XP_009294978.2  glucose-6-phosphate 1-dehydrogenase isoform X2

    UniProtKB/TrEMBL
    A0A8M3AY75
    Conserved Domains (1) summary
    cl27363
    Location:42 → 528
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  4. XM_068216878.1 → XP_068072979.1  glucose-6-phosphate 1-dehydrogenase isoform X4

  5. XM_068216877.1 → XP_068072978.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    Related
    ENSDARP00000151797.1, ENSDART00000193807.1

  6. XM_009296704.4 → XP_009294979.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    See identical proteins and their annotated locations for XP_009294979.1

    UniProtKB/TrEMBL
    A0A8M9Q598, E7FDY7
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  7. XM_009296706.4 → XP_009294981.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    See identical proteins and their annotated locations for XP_009294981.1

    UniProtKB/TrEMBL
    A0A8M9Q598, E7FDY7
    Related
    ENSDARP00000095604.4, ENSDART00000104834.6
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  8. XM_021469916.2 → XP_021325591.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q598, E7FDY7
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  9. XM_017353737.3 → XP_017209226.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q598, E7FDY7
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395134.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    153055..182734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473587.2 → XP_021329262.1  glucose-6-phosphate 1-dehydrogenase isoform X3

    UniProtKB/TrEMBL
    A0A8M9PDT5
    Conserved Domains (1) summary
    cl27363
    Location:37 → 523
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  2. XM_021473585.2 → XP_021329260.1  glucose-6-phosphate 1-dehydrogenase isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q7P5
    Conserved Domains (1) summary
    cl27363
    Location:48 → 534
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  3. XM_021473586.2 → XP_021329261.1  glucose-6-phosphate 1-dehydrogenase isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q3J7
    Conserved Domains (1) summary
    cl27363
    Location:42 → 528
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  4. XM_068219028.1 → XP_068075129.1  glucose-6-phosphate 1-dehydrogenase isoform X4

  5. XM_021473588.2 → XP_021329263.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    UniProtKB/TrEMBL
    A0A8M9PWR3
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  6. XM_021473590.2 → XP_021329265.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    UniProtKB/TrEMBL
    A0A8M9PWR3
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395358.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    61063..90901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474503.2 → XP_021330178.1  glucose-6-phosphate 1-dehydrogenase isoform X3

    UniProtKB/TrEMBL
    A0A8M9PT34, F6NHI0
    Conserved Domains (1) summary
    cl27363
    Location:37 → 523
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  2. XM_021474501.2 → XP_021330176.1  glucose-6-phosphate 1-dehydrogenase isoform X1

    UniProtKB/TrEMBL
    A0A8M2B959
    Conserved Domains (1) summary
    cl27363
    Location:48 → 534
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  3. XM_021474502.2 → XP_021330177.1  glucose-6-phosphate 1-dehydrogenase isoform X2

    UniProtKB/TrEMBL
    A0A8M3AY75
    Conserved Domains (1) summary
    cl27363
    Location:42 → 528
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  4. XM_068219381.1 → XP_068075482.1  glucose-6-phosphate 1-dehydrogenase isoform X4

  5. XM_068219380.1 → XP_068075481.1  glucose-6-phosphate 1-dehydrogenase isoform X4

  6. XM_021474504.2 → XP_021330179.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q598, E7FDY7
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  7. XM_021474506.2 → XP_021330181.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q598, E7FDY7
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  8. XM_021474505.2 → XP_021330180.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q598, E7FDY7
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

  9. XM_021474507.2 → XP_021330182.1  glucose-6-phosphate 1-dehydrogenase isoform X4

    UniProtKB/TrEMBL
    A0A8M9Q598, E7FDY7
    Conserved Domains (1) summary
    cl27363
    Location:27 → 513
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain
Nucleotide Protein Strain
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