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ttc21b tetratricopeptide repeat domain 21B [ Danio rerio (zebrafish) ]

Gene ID: 569823, updated on 2-Nov-2024

Summary

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Official Symbol
ttc21bprovided by ZNC
Official Full Name
tetratricopeptide repeat domain 21Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031010-34
See related
Ensembl:ENSDARG00000012368 AllianceGenome:ZFIN:ZDB-GENE-031010-34
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:cb947
Summary
Acts upstream of or within gastrulation. Predicted to be part of intraciliary transport particle A. Is expressed in Kupffer's vesicle; forerunner cell group; neural tube; and pronephric duct. Human ortholog(s) of this gene implicated in asphyxiating thoracic dystrophy 4 and nephronophthisis 12. Orthologous to human TTC21B (tetratricopeptide repeat domain 21B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ttc21b in Genome Data Viewer
Location:
chromosome: 9
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (49808483..49860756, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (50111092..50163365, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cysteine-serine-rich nuclear protein 3 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) Neighboring gene uncharacterized LOC137496435 Neighboring gene sodium channel, voltage-gated, type I-like, alpha Neighboring gene solute carrier family 38 member 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes. Chen W, et al. Hum Genomics, 2022 Oct 22. PMID 36273201, Free PMC Article
  2. TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum. Davis EE, et al. Nat Genet, 2011 Mar. PMID 21258341, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within gastrulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 21B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128258.1 → NP_001121730.1  tetratricopeptide repeat protein 21B

    Status: PROVISIONAL

    Source sequence(s)
    AL929294
    UniProtKB/TrEMBL
    A0A8M1NHS0, B0R0W1
    Related
    ENSDARP00000044269.8, ENSDART00000044270.11
    Conserved Domains (4) summary
    TIGR02917
    Location:16 → 822
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:730 → 755
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:1205 → 1266
    TPR_11; TPR repeat
    pfam13432
    Location:927 → 990
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    49808483..49860756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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