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wrn WRN RecQ like helicase [ Danio rerio (zebrafish) ]

Gene ID: 569495, updated on 2-Nov-2024

Summary

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Official Symbol
wrnprovided by ZNC
Official Full Name
WRN RecQ like helicaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070702-2
See related
Ensembl:ENSDARG00000098211 AllianceGenome:ZFIN:ZDB-GENE-070702-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable 3'-5' DNA helicase activity and four-way junction helicase activity. Acts upstream of or within bone growth. Predicted to be active in chromosome; cytoplasm; and nucleoplasm. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See wrn in Genome Data Viewer
Location:
chromosome: 10
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (7482262..7555660, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (7522784..7597066, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene fucosyltransferase 10 Neighboring gene neuregulin 1 Neighboring gene testis expressed 15, meiosis and synapsis associated Neighboring gene purine-rich element binding protein G Neighboring gene protein phosphatase 2, catalytic subunit, beta isozyme

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Bloom syndrome helicase contributes to germ line development and longevity in zebrafish. Annus T, et al. Cell Death Dis, 2022 Apr 18. PMID 35436990, Free PMC Article
  2. PLRG1 is an essential regulator of cell proliferation and apoptosis during vertebrate development and tissue homeostasis. Kleinridders A, et al. Mol Cell Biol, 2009 Jun. PMID 19307306, Free PMC Article
  3. WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Tian Y, et al. Nat Commun, 2022 Sep 16. PMID 36114168, Free PMC Article
  4. WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome. Tian Y, et al. Cell Biosci, 2024 Jan 6. PMID 38184705, Free PMC Article
  5. Large-scale generation and phenotypic characterization of zebrafish CRISPR mutants of DNA repair genes. Shin U, et al. DNA Repair (Amst), 2021 Nov. PMID 34390914

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G-quadruplex DNA unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bone growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
Names
Werner syndrome ATP-dependent helicase homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    7482262..7555660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479248.2 → XP_021334923.1  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1

    UniProtKB/TrEMBL
    A0A0R4IT14, A0A8M9Q6A5
    Related
    ENSDARP00000139077.1, ENSDART00000162191.2
    Conserved Domains (4) summary
    cd06141
    Location:48 → 217
    WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
    pfam14493
    Location:1155 → 1242
    HTH_40; Helix-turn-helix domain
    cl02578
    Location:1045 → 1116
    HRDC; HRDC domain
    cl26939
    Location:433 → 901
    DEXDc; DEAD-like helicases superfamily

  2. XM_068223902.1 → XP_068080003.1  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394765.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    124577..197838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303971.4 → XP_009302246.2  bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X1

    UniProtKB/TrEMBL
    A0A8M3AV58
    Conserved Domains (4) summary
    cd06141
    Location:48 → 217
    WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
    pfam14493
    Location:1155 → 1242
    HTH_40; Helix-turn-helix domain
    cl02578
    Location:1045 → 1116
    HRDC; HRDC domain
    cl26939
    Location:433 → 901
    DEXDc; DEAD-like helicases superfamily
Nucleotide Protein Strain
Heading Accession and Version

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