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MEIS3 Meis homeobox 3 [ Homo sapiens (human) ]

Gene ID: 56917, updated on 2-Nov-2024

Summary

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Official Symbol
MEIS3provided by HGNC
Official Full Name
Meis homeobox 3provided by HGNC
Primary source
HGNC:HGNC:29537
See related
Ensembl:ENSG00000105419 MIM:619443; AllianceGenome:HGNC:29537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRG2
Summary
This gene encodes a homeobox protein and probable transcriptional regulator. The orthologous protein in mouse controls expression of 3-phosphoinositide dependent protein kinase 1, which promotes survival of pancreatic beta-cells. [provided by RefSeq, Sep 2016]
Expression
Biased expression in endometrium (RPKM 15.5), brain (RPKM 9.1) and 10 other tissues See more
Orthologs
mouse all
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Genomic context

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See MEIS3 in Genome Data Viewer
Location:
19q13.32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47403124..47422233, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50228571..50253087, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47906381..47925490, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47852412-47853316 Neighboring gene complement C5a receptor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47858319-47858818 Neighboring gene DExH-box helicase 34 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47895565-47896211 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47896212-47896859 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47901415-47902082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905147-47905846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905847-47906546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47906547-47907244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47920878-47921870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47921871-47922864 Neighboring gene hESC enhancers GRCh37_chr19:47931091-47931659 and GRCh37_chr19:47931660-47932227 Neighboring gene Sharpr-MPRA regulatory region 169 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47939851-47940352 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47945299-47945446 Neighboring gene solute carrier family 8 member A2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47949904-47950829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47971701-47972200 Neighboring gene Sharpr-MPRA regulatory region 3844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14866 Neighboring gene NAPA antisense RNA 1 Neighboring gene kaptin, actin binding protein Neighboring gene NSF attachment protein alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt. Cai P, et al. Biomed Res Int, 2020. PMID 33376716, Free PMC Article
  2. MEIS3 is repressed in A549 lung epithelial cells by deoxynivalenol and the repression contributes to the deleterious effect. Toyotome T, et al. J Toxicol Sci, 2016 Feb. PMID 26763390
  3. An autoinhibitory effect of the homothorax domain of Meis2. Hyman-Walsh C, et al. FEBS J, 2010 Jun. PMID 20553494, Free PMC Article
  4. Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development. Uribe RA, et al. Mol Biol Cell, 2015 Nov 1. PMID 26354419, Free PMC Article
  5. Identification of a new family of Pbx-related homeobox genes. Nakamura T, et al. Oncogene, 1996 Nov 21. PMID 8950991

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt.
    Title: Inhibition of MEIS3 Generates Cetuximab Resistance through c-Met and Akt.
  2. Findings support a model in which Meis3 is required for neural crest proliferation, migration into, and colonization of the gut such that its loss leads to severe defects in enteric nervous system development.
    Title: Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development.
  3. This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.
    Title: An autoinhibitory effect of the homothorax domain of Meis2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp547H236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
homeobox protein Meis3
Names
Meis1, myeloid ecotropic viral integration site 1 homolog 3
meis1-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051644.1 RefSeqGene

    Range
    7707..24110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001009813.3 → NP_001009813.1  homeobox protein Meis3 isoform 2

    See identical proteins and their annotated locations for NP_001009813.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame acceptor splice sites at two internal exon junctions compared to variant 1, which results in a shorter isoform (2) missing two internal protein segments compared to isoform 1.
    Source sequence(s)
    AL537583, BC069251, CF993984
    Consensus CDS
    CCDS46132.1
    UniProtKB/Swiss-Prot
    A8K0S8
    Related
    ENSP00000388667.2, ENST00000441740.6
    Conserved Domains (2) summary
    pfam05920
    Location:263 → 302
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 162
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. NM_001301059.2 → NP_001287988.1  homeobox protein Meis3 isoform 3

    See identical proteins and their annotated locations for NP_001287988.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AL537583, BC045741, BI522513, BM783223, CF993984
    Consensus CDS
    CCDS74406.1
    UniProtKB/Swiss-Prot
    A8K0S8, A8K1N5, Q6NT73, Q8TC66, Q99687, Q9NPW2
    Related
    ENSP00000454073.1, ENST00000558555.6
    Conserved Domains (2) summary
    pfam05920
    Location:280 → 319
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 179
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. NM_001346148.2 → NP_001333077.1  homeobox protein Meis3 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC073548
    UniProtKB/Swiss-Prot
    A8K0S8

  4. NM_020160.3 → NP_064545.1  homeobox protein Meis3 isoform 1

    See identical proteins and their annotated locations for NP_064545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL537583, BC025404, CF993984, DB545063
    Consensus CDS
    CCDS33064.1
    UniProtKB/Swiss-Prot
    A8K0S8
    Related
    ENSP00000453307.1, ENST00000561293.5
    Conserved Domains (2) summary
    pfam05920
    Location:329 → 365
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 179
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    47403124..47422233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451615.2 → XP_024307383.1  homeobox protein Meis3 isoform X4

    UniProtKB/Swiss-Prot
    A8K0S8
    Conserved Domains (2) summary
    pfam05920
    Location:326 → 362
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:93 → 176
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  2. XM_024451616.2 → XP_024307384.1  homeobox protein Meis3 isoform X6

    UniProtKB/Swiss-Prot
    A8K0S8
    UniProtKB/TrEMBL
    H3BLU4
    Related
    ENSP00000333552.4, ENST00000331559.9
    Conserved Domains (2) summary
    pfam05920
    Location:312 → 348
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:96 → 162
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  3. XM_024451617.2 → XP_024307385.1  homeobox protein Meis3 isoform X7

    Related
    ENST00000561204.5
    Conserved Domains (2) summary
    pfam05920
    Location:197 → 233
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:1 → 47
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  4. XM_017027011.2 → XP_016882500.1  homeobox protein Meis3 isoform X5

    UniProtKB/TrEMBL
    H0YNA8
    Related
    ENSP00000453934.1, ENST00000561096.5

  5. XM_024451613.2 → XP_024307381.1  homeobox protein Meis3 isoform X2

    Conserved Domains (2) summary
    pfam05920
    Location:400 → 436
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184 → 250
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  6. XM_024451612.2 → XP_024307380.1  homeobox protein Meis3 isoform X1

    Conserved Domains (2) summary
    pfam05920
    Location:417 → 453
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184 → 267
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  7. XM_011527136.4 → XP_011525438.1  homeobox protein Meis3 isoform X3

    Conserved Domains (2) summary
    pfam05920
    Location:351 → 390
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:184 → 250
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

  8. XM_047439109.1 → XP_047295065.1  homeobox protein Meis3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    50228571..50253087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321499.1 → XP_054177474.1  homeobox protein Meis3 isoform X4

  2. XM_054321501.1 → XP_054177476.1  homeobox protein Meis3 isoform X6

    UniProtKB/TrEMBL
    H3BLU4

  3. XM_054321502.1 → XP_054177477.1  homeobox protein Meis3 isoform X7

  4. XM_054321500.1 → XP_054177475.1  homeobox protein Meis3 isoform X5

    UniProtKB/TrEMBL
    H0YNA8

  5. XM_054321497.1 → XP_054177472.1  homeobox protein Meis3 isoform X2

  6. XM_054321495.1 → XP_054177470.1  homeobox protein Meis3 isoform X1

  7. XM_054321498.1 → XP_054177473.1  homeobox protein Meis3 isoform X3

  8. XM_054321496.1 → XP_054177471.1  homeobox protein Meis3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99687.3 GenPept UniProtKB/Swiss-Prot:Q99687

Gene LinkOut

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