srpra SRP receptor subunit alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: srpraprovided by ZNC
Official Full Name: SRP receptor subunit alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030219-11
See related: Ensembl:ENSDARG00000061124 AllianceGenome:ZFIN:ZDB-GENE-030219-11
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: srpr; id:ibd1064; wu:fd12f02
Summary: Predicted to enable GTPase activity and signal recognition particle binding activity. Predicted to be involved in protein targeting to ER. Predicted to act upstream of or within SRP-dependent cotranslational protein targeting to membrane. Predicted to be part of signal recognition particle receptor complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in brain. Orthologous to human SRPRA (SRP receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (44826173..44847850, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (44832719..44854401, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fd12f02.x1 (e-PCR)
- UniSTS:195168

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables signal recognition particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal recognition particle binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle receptor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal recognition particle receptor subunit alpha

Names: signal recognition particle receptor (docking protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

44826173..44847850 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_692426.9 → XP_697518.3 signal recognition particle receptor subunit alpha

UniProtKB/TrEMBL

A0A8N7UW26, E7EZW6

Related

ENSDARP00000081257.5, ENSDART00000086823.6

Conserved Domains (4) summary

smart00963
Location:336 → 409

SRP54_N; SRP54-type protein, helical bundle domain

cd03115
Location:431 → 627

SRP; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The ...

TIGR00064
Location:348 → 647

ftsY; signal recognition particle-docking protein FtsY

pfam04086
Location:29 → 297

SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal