U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C15orf39 chromosome 15 open reading frame 39 [ Homo sapiens (human) ]

Gene ID: 56905, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
C15orf39provided by HGNC
Official Full Name
chromosome 15 open reading frame 39provided by HGNC
Primary source
HGNC:HGNC:24497
See related
Ensembl:ENSG00000167173 AllianceGenome:HGNC:24497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 35.8), bone marrow (RPKM 21.8) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15q24.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75198889..75212169)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73068928..73082210)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75494223..75504510)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75480455-75480956 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75480957-75481456 Neighboring gene ribosomal protein L36a pseudogene 45 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75484212-75484914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75487637-75488181 Neighboring gene uncharacterized LOC107984772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9839 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75493826-75494548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9846 Neighboring gene taste receptor cell protein 1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75529495-75530112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75530113-75530729 Neighboring gene NIFK pseudogene 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Large-scale cDNA transfection screening for genes related to cancer development and progression. Wan D, et al. Proc Natl Acad Sci U S A, 2004 Nov 2. PMID 15498874, Free PMC Article
  2. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. Achuthankutty D, et al. J Cell Biol, 2019 Dec 2. PMID 31615875, Free PMC Article
  3. An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase. Zhou Z, et al. iScience, 2022 Feb 18. PMID 35198878, Free PMC Article
  4. Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs. Almasy KM, et al. Mol Cell Proteomics, 2021. PMID 34186245, Free PMC Article
  5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Elzi DJ, et al. J Proteome Res, 2014 Aug 1. PMID 24999758, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ46337, MGC117209, DKFZp434H132

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein C15orf39

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015492.5 → NP_056307.3  uncharacterized protein C15orf39

    Status: VALIDATED

    Source sequence(s)
    AC113208
    Consensus CDS
    CCDS10276.1
    UniProtKB/Swiss-Prot
    B3KWI3, C9J888, Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5
    Related
    ENSP00000378438.4, ENST00000394987.5
    Conserved Domains (1) summary
    cl26464
    Location:164 → 563
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    75198889..75212169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432864.1 → XP_047288820.1  uncharacterized protein C15orf39 isoform X1

    UniProtKB/Swiss-Prot
    B3KWI3, C9J888, Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5
    Related
    ENSP00000353854.2, ENST00000360639.6

  2. XM_047432865.1 → XP_047288821.1  uncharacterized protein C15orf39 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    73068928..73082210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378458.1 → XP_054234433.1  uncharacterized protein C15orf39 isoform X1

  2. XM_054378460.1 → XP_054234435.1  uncharacterized protein C15orf39 isoform X2

  3. XM_054378459.1 → XP_054234434.1  uncharacterized protein C15orf39 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZRI6.3 GenPept UniProtKB/Swiss-Prot:Q6ZRI6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous