plcd3a phospholipase C, delta 3a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plcd3aprovided by ZNC
Official Full Name: phospholipase C, delta 3aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070620-1
See related: Ensembl:ENSDARG00000052957 AllianceGenome:ZFIN:ZDB-GENE-070620-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158396
Summary: Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to act upstream of or within intracellular signal transduction and lipid catabolic process. Predicted to be located in cleavage furrow and cytoplasm. Predicted to be active in plasma membrane. Is expressed in spinal cord. Orthologous to human PLCD3 (phospholipase C delta 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (39260082..39305291, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (39118224..39163433, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A

Names: DrPLC-delta 3A; PLC-delta-3-A; phosphoinositide phospholipase C-delta-3-A; phospholipase C-delta-3-A

NP_001092893.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099423.1 → NP_001092893.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A

See identical proteins and their annotated locations for NP_001092893.1

Status: PROVISIONAL

Source sequence(s)

BC139849

UniProtKB/Swiss-Prot

A5D6R3

Related

ENSDARP00000093449.3, ENSDART00000102674.6

Conserved Domains (8) summary

cd00275
Location:640 → 767

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08630
Location:312 → 608

PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3

PLN02952
Location:236 → 768

PLN02952; phosphoinositide phospholipase C

cd13363
Location:40 → 158

PH_PLC_delta; Phospholipase C-delta (PLC-delta) pleckstrin homology (PH) domain

pfam00169
Location:48 → 145

PH; PH domain

pfam09279
Location:232 → 312

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

pfam13499
Location:164 → 227

EF-hand_7; EF-hand domain pair

pfam14788
Location:178 → 227

EF-hand_10; EF hand