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PNO1 partner of NOB1 homolog [ Homo sapiens (human) ]

Gene ID: 56902, updated on 5-Mar-2024

Summary

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Official Symbol
PNO1provided by HGNC
Official Full Name
partner of NOB1 homologprovided by HGNC
Primary source
HGNC:HGNC:32790
See related
Ensembl:ENSG00000115946 MIM:618710; AllianceGenome:HGNC:32790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRP20; KHRBP1
Summary
Enables RNA binding activity. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 8.8), adrenal (RPKM 8.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (68157888..68176238)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (68168438..68186793)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68385020..68403370)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 64 Neighboring gene dynein axonemal assembly factor 10 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:68383902-68384834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15947 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59016 Neighboring gene VISTA enhancer hs2040 Neighboring gene protein phosphatase 3 regulatory subunit B, alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:68432700-68433200 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59162 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59182 Neighboring gene uncharacterized LOC107985892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:68480114-68480783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11589 Neighboring gene cannabinoid receptor interacting protein 1 Neighboring gene Sharpr-MPRA regulatory region 10638

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9 technique suppresses lung adenocarcinoma and Notch pathway: Clinical application. Roy SK, et al. J Cell Mol Med, 2023 Feb. PMID 36625087, Free PMC Article
  2. PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma. Hu X, et al. Cell Death Dis, 2022 Nov 29. PMID 36446769, Free PMC Article
  3. Ribosome assembly factor PNO1 is associated with progression and promotes tumorigenesis in triple‑negative breast cancer. Li J, et al. Oncol Rep, 2022 Jun. PMID 35445733, Free PMC Article
  4. PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway. Han Z, et al. Cell Death Dis, 2021 May 28. PMID 34050137, Free PMC Article
  5. Knockdown of PNO1 inhibits esophageal cancer progression. Wang G, et al. Oncol Rep, 2021 May. PMID 33864661, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PNO1 promotes the progression of osteosarcoma via TGF-beta and YAP/TAZ pathway.
    Title: PNO1 promotes the progression of osteosarcoma via TGF-β and YAP/TAZ pathway.
  2. Partner of NOB1 homolog transcriptionally activated by E2F transcription factor 1 promotes the malignant progression and inhibits ferroptosis of pancreatic cancer.
    Title: Partner of NOB1 homolog transcriptionally activated by E2F transcription factor 1 promotes the malignant progression and inhibits ferroptosis of pancreatic cancer.
  3. Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9 technique suppresses lung adenocarcinoma and Notch pathway: Clinical application.
    Title: Inhibition of ribosome assembly factor PNO1 by CRISPR/Cas9 technique suppresses lung adenocarcinoma and Notch pathway: Clinical application.
  4. PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma.
    Title: PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma.
  5. Ribosome assembly factor PNO1 is associated with progression and promotes tumorigenesis in triplenegative breast cancer.
    Title: Ribosome assembly factor PNO1 is associated with progression and promotes tumorigenesis in triple‑negative breast cancer.
  6. PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity.
    Title: PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity.
  7. Knockdown of PNO1 inhibits esophageal cancer progression.
    Title: Knockdown of PNO1 inhibits esophageal cancer progression.
  8. PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway.
    Title: PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway.
  9. MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1/FAK/Akt signaling.
    Title: MYC-mediated upregulation of PNO1 promotes glioma tumorigenesis by activating THBS1/FAK/Akt signaling.
  10. Importance of PNO1 for growth and survival of urinary bladder carcinoma: Role in core-regulatory circuitry.
    Title: Importance of PNO1 for growth and survival of urinary bladder carcinoma: Role in core-regulatory circuitry.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ribosomal small subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of small-subunit processome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA-binding protein PNO1
Names
KH-type RNA-binding protein 1
RNA binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329916.2 → NP_001316845.1  RNA-binding protein PNO1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC017083
    UniProtKB/TrEMBL
    B2R823

  2. NM_001329917.2 → NP_001316846.1  RNA-binding protein PNO1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC017083
    UniProtKB/TrEMBL
    B2R823

  3. NM_020143.4 → NP_064528.1  RNA-binding protein PNO1 isoform 1

    See identical proteins and their annotated locations for NP_064528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC017083, BC008304
    Consensus CDS
    CCDS1885.1
    UniProtKB/Swiss-Prot
    A8K6Q0, Q53G13, Q8WVB8, Q9NRX1
    UniProtKB/TrEMBL
    B2R823
    Related
    ENSP00000263657.2, ENST00000263657.7
    Conserved Domains (2) summary
    cd22391
    Location:73 → 152
    KH-I_PNO1_rpt1; first type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins
    cd22392
    Location:154 → 249
    KH-I_PNO1_rpt2; second type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins

RNA

  1. NR_138146.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC017083

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    68157888..68176238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    68168438..68186793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NRX1.1 GenPept UniProtKB/Swiss-Prot:Q9NRX1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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