U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

il1rapl1a interleukin 1 receptor accessory protein-like 1a [ Danio rerio (zebrafish) ]

Gene ID: 568868, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
il1rapl1aprovided by ZNC
Official Full Name
interleukin 1 receptor accessory protein-like 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061013-249
See related
Ensembl:ENSDARG00000062045 AllianceGenome:ZFIN:ZDB-GENE-061013-249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi18g04; wu:fi18g04; zgc:152866
Summary
Predicted to enable several functions, including RNA-DNA hybrid ribonuclease activity; hydrolase activity, hydrolyzing N-glycosyl compounds; and interleukin-1 receptor activity. Predicted to be involved in cell surface receptor signaling pathway and negative regulation of exocytosis. Predicted to act upstream of or within DNA integration and signal transduction. Predicted to be located in cytoplasm and membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in optic tectum and telencephalon. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See il1rapl1a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (29716380..29985402, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (29905634..30174804, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885868 Neighboring gene TLR adapter interacting with SLC15A4 on the lysosome Neighboring gene cms1 ribosomal small subunit homolog Neighboring gene transmembrane protein 30C Neighboring gene discoidin, CUB and LCCL domain containing 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zebrafish orthologue of mental retardation protein IL1RAPL1 regulates presynaptic differentiation. Yoshida T, et al. Mol Cell Neurosci, 2008 Oct. PMID 18657618
  2. Channa Striatus Protects Against PTZ-Induced Seizures in LPS Pre-conditioned Zebrafish Model. Lee VLL, et al. Front Pharmacol, 2022. PMID 35444543, Free PMC Article
  3. Orthosiphon stamineus Leaf Extract Affects TNF-α and Seizures in a Zebrafish Model. Choo BKM, et al. Front Pharmacol, 2018. PMID 29527169, Free PMC Article
  4. Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators. Nguyen T, et al. J Inflamm Res, 2019. PMID 31695470, Free PMC Article
  5. Pilocarpine Induced Behavioral and Biochemical Alterations in Chronic Seizure-Like Condition in Adult Zebrafish. Paudel YN, et al. Int J Mol Sci, 2020 Apr 3. PMID 32260203, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC152866

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA integration IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
interleukin-1 receptor accessory protein-like 1-A
NP_001071044.2
XP_005174755.1
XP_009303034.1
XP_017213199.1
XP_021334423.1
XP_068079563.1
XP_068079564.1
XP_068079565.1
XP_068079566.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077576.2 → NP_001071044.2  interleukin-1 receptor accessory protein-like 1-A precursor

    Status: VALIDATED

    Source sequence(s)
    BX649442, BX957250, CR749776, CR753904
    UniProtKB/TrEMBL
    A0A8M9Q4P6
    Related
    ENSDARP00000117551.1, ENSDART00000134157.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    29716380..29985402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223462.1 → XP_068079563.1  interleukin-1 receptor accessory protein-like 1-A isoform X1

  2. XM_005174698.5 → XP_005174755.1  interleukin-1 receptor accessory protein-like 1-A isoform X2

    See identical proteins and their annotated locations for XP_005174755.1

    UniProtKB/Swiss-Prot
    B6ZK76, Q08BS0
    UniProtKB/TrEMBL
    A0A8M9Q4P6
    Conserved Domains (4) summary
    cd05896
    Location:33 → 138
    Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
    smart00255
    Location:408 → 579
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:244 → 341
    Ig_3; Immunoglobulin domain
    cl11960
    Location:152 → 242
    Ig; Immunoglobulin domain

  3. XM_009304759.4 → XP_009303034.1  interleukin-1 receptor accessory protein-like 1-A isoform X2

    See identical proteins and their annotated locations for XP_009303034.1

    UniProtKB/Swiss-Prot
    B6ZK76, Q08BS0
    UniProtKB/TrEMBL
    A0A8M9Q4P6
    Conserved Domains (4) summary
    cd05896
    Location:33 → 138
    Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
    smart00255
    Location:408 → 579
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:244 → 341
    Ig_3; Immunoglobulin domain
    cl11960
    Location:152 → 242
    Ig; Immunoglobulin domain

  4. XM_068223465.1 → XP_068079566.1  interleukin-1 receptor accessory protein-like 1-A isoform X3

  5. XM_017357710.3 → XP_017213199.1  interleukin-1 receptor accessory protein-like 1-A isoform X2

    UniProtKB/Swiss-Prot
    B6ZK76, Q08BS0
    UniProtKB/TrEMBL
    A0A8M9Q4P6
    Conserved Domains (4) summary
    cd05896
    Location:33 → 138
    Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
    smart00255
    Location:408 → 579
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:244 → 341
    Ig_3; Immunoglobulin domain
    cl11960
    Location:152 → 242
    Ig; Immunoglobulin domain

  6. XM_068223463.1 → XP_068079564.1  interleukin-1 receptor accessory protein-like 1-A isoform X2

  7. XM_068223464.1 → XP_068079565.1  interleukin-1 receptor accessory protein-like 1-A isoform X3

  8. XM_021478748.2 → XP_021334423.1  interleukin-1 receptor accessory protein-like 1-A isoform X2

    UniProtKB/Swiss-Prot
    B6ZK76, Q08BS0
    UniProtKB/TrEMBL
    A0A8M9Q4P6
    Conserved Domains (4) summary
    cd05896
    Location:33 → 138
    Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
    smart00255
    Location:408 → 579
    TIR; Toll - interleukin 1 - resistance
    pfam13927
    Location:244 → 341
    Ig_3; Immunoglobulin domain
    cl11960
    Location:152 → 242
    Ig; Immunoglobulin domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394759.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    316731..388566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395285.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    71960..338691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B6ZK76.1 GenPept UniProtKB/Swiss-Prot:B6ZK76

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools