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snx2 sorting nexin 2 [ Danio rerio (zebrafish) ]

Gene ID: 568737, updated on 2-Nov-2024

Summary

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Official Symbol
snx2provided by ZNC
Official Full Name
sorting nexin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-051120-45
See related
AllianceGenome:ZFIN:ZDB-GENE-051120-45
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:123293
Summary
Predicted to enable phosphatidylinositol binding activity. Predicted to act upstream of or within intracellular protein transport. Predicted to be located in early endosome membrane and lamellipodium. Predicted to be part of retromer complex. Orthologous to human SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: suggests misassembly
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See snx2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (144091..175648)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (293270..324827)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene lysyl oxidase Neighboring gene synuclein, alpha interacting protein Neighboring gene solute carrier family 12 member 2-like Neighboring gene zinc finger protein 608

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish. Yoo KW, et al. FEBS Lett, 2006 Aug 7. PMID 16857196
  2. An antiapoptotic role of sorting nexin 7 is required for liver development in zebrafish. Xu L, et al. Hepatology, 2012 Jun. PMID 22213104
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC123293

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
part_of retromer complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037698.1 → NP_001032787.1  sorting nexin-2

    Status: PROVISIONAL

    Source sequence(s)
    BC109441
    UniProtKB/TrEMBL
    Q32LT0
    Conserved Domains (3) summary
    cd07282
    Location:129 → 252
    PX_SNX2; The phosphoinositide binding Phox Homology domain of Sorting Nexin 2
    cd07664
    Location:270 → 503
    BAR_SNX2; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 2
    pfam03700
    Location:33 → 101
    Sorting_nexin; Sorting nexin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    144091..175648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials