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atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [ Danio rerio (zebrafish) ]

Gene ID: 568671, updated on 12-Sep-2024

Summary

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Official Symbol
atp2a3provided by ZNC
Official Full Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-060531-103
See related
Ensembl:ENSDARG00000060978 AllianceGenome:ZFIN:ZDB-GENE-060531-103
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-205l20.1
Summary
Predicted to enable P-type calcium transporter activity. Predicted to be involved in calcium ion transmembrane transport and cellular calcium ion homeostasis. Predicted to act upstream of or within calcium ion transport. Predicted to be located in membrane and sarcoplasmic reticulum. Predicted to be integral component of membrane. Is expressed in Purkinje cell. Orthologous to human ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See atp2a3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (31167845..31269191)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (30567463..30669038)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene cytochrome b5 domain containing 2 Neighboring gene zinc finger, ZZ-type with EF hand domain 1 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha a Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Thyroid hormone regulates muscle function during cold acclimation in zebrafish (Danio rerio). Little AG, et al. J Exp Biol, 2013 Sep 15. PMID 23966591
  2. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Names
ATPase, Ca++ transporting, ubiquitous
XP_009299855.1
XP_697108.5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    31167845..31269191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301580.4 → XP_009299855.1  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M3ASL2, F1Q4P9
    Related
    ENSDARP00000080878.5, ENSDART00000086443.7
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 986
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:781 → 984
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:601 → 709
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 525
    Cation_ATPase; Cation transport ATPase (P-type)

  2. XM_692016.10 → XP_697108.5  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1

    UniProtKB/TrEMBL
    A0A2R8QJH4, A0A8N7TFK9
    Related
    ENSDARP00000154326.1, ENSDART00000192271.1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 986
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:92 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:781 → 984
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:601 → 709
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 525
    Cation_ATPase; Cation transport ATPase (P-type)
Nucleotide Protein Strain
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